Chan, Jerry

Research Interests:

My research interests are in the characterisation of fetal stem cells, such as mesenchymal stem cells, haemopoietic stem cells, endothelial progenitor cells and neural stem cells, and developing their translational use for both fetal and post-natal therapy, and in tissue engineering through studies of directed differentiation, homing and migration, and cell-cell interactions. We work with small and large animal models of different diseases and inherited conditions through xeno-transplantation, and utilise transcriptomics, proteomics and micro-fluidics approaches to delineate stem cell potency and interactions with other cell types of interest. Derivation of cGMP mesenchymal stem cells for bone repair and fetal transplantation is being developed.

Another area of research is into fetal gene transfer with non-human primates, allowing both safety and efficacy of such approaches to be assessed in the only animal model which approximates human fetal ontogeny and placentation.

Clinical research interests encompasses reproductive medicine in areas such as fertility preservation, development of novel ovarian reserve biomarkers and delineating the pathogenesis of endometriosis through application of tissue engineering principles and biosensing technologies.

Selected Publications:

Chong MS, Teoh SH, Teo EY, Lee CN, Koh S, Choolani M, Chan J. CD34 antibody conjugation onto μXPCL film surfaces contributes to haemocompatibility by reducing procoagulatory blood responses. Tissue Engineering 2010 (In Press)

Kobayashi N, Lin S, Tan PSL, Lim EKH, Chan J, Choolani M and Crook JM. Modelling Disrupted-in-Schizophrenia 1 loss of function in human neural progenitor cells: tools for molecular studies of human neurodevelopment and neuropsychiatric disorder. Molecular Psychiatry 2010 (In Press)

Zhang ZY, Teoh SH, Chong MS, Lee ES, Tan LG, Mattar CN, Fisk NM, Choolani M, Chan J. Neo-Vascularization And Bone Formation Mediated By Fetal MSC Tissue-Engineered Bone Grafts In Critical Sized Femoral Defects. Biomaterials. 2010 Feb;31(4):608-20

Lee ES, Chan J, Shuter B, Tan LG, Chong MS, Ramachandra D, Dawe G, Ding J, Teoh SH, Beuf O, Briguet A, Tam M, Choolani M, Wang SC. Microgel Iron Oxide Nanoparticles For Tracking Human Fetal Mesenchymal Stem Cells Through Magnetic Resonance Imaging. Stem Cells 2009 Aug;27(8):1921 -1931 *Corresponding Author

Zhi-Yong Zhang, Swee-Hin Teoh, Mark SK Chong, Jan Thorsten Schantz, Nicholas M Fisk, Mahesh A Choolani, Jerry Chan. Superior osteogenic capacity for bone tissue engineering of fetal compared to perinatal and adult MSC. Stem Cells 2009 Jan;27(1):126 –137

Guillot PV, Abass O, Chapon C, Bassett DJH, Shefelbine SJ, Bou-Gharios G, Chan J, Kurata H, Bakhoo K, Williams G, Polak J and Fisk NM. Intrauterine transplantation of human fetal mesenchymal stem cells reduces bone pathology in osteogenesis imperfecta mice. Blood 2008 111;(3): 1717-1725

Chan J, Waddington SN, O'Donoghue K, Kurata H, Guillot P, Gotherstrom C, Themis M, Morgan JE, Fisk NM. Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse. Stem Cells 2007 Apr;25(4) 875-884

Chan J, O'Donoghue K, Gavina M, Torrente Y, Kennea N, Mehmet H, Stewart H, Watt D, Morgan JE, Fisk NM. Galectin-1 induces skeletal muscle differentiation in human fetal mesenchymal stem cells and increases muscle regeneration. Stem Cells. 2006 Aug;24(8):1879-91

Chan J, O'Donoghue K, de la Fuente J, Kumar S, Roberts IA, Morgan JE, Fisk NM: Human fetal mesenchymal stem cells as vehicles for gene delivery. Stem Cells 23 (1) 93-102, 2005.

O'Donoghue K, Chan J, de la Fuente J, Kennea N, Sandison A, Anderson JR, Roberts IAG, Fisk NM: Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem cell trafficking in pregnancy. The Lancet 364: 179-82, 2004.