Keefe, Richard

Research Interests:

Cognition and cognitive neuroscience Cognition in schizophrenia and other psychiatric disorders Effects of pharmacologic treatment on cognition in schizophrenia and psychotic disorders Predictors of conversion to psychosis in individuals at ultra-high risk for schizophrenia Theories of neural circuitry impairment in psychotic disorders Development of treatments for cognitive impairment in psychiatric disorders Cognitive remediation Anti microbials, Biomarkers

Selected Publications:

Keefe RSE, Silverman J, Mohs RC, Siever LJ, Harvey PD, Friedman L, Lees Roitman SE, DuPre RL, Smith CJ, Schmeidler J, Davis KL. Eye tracking, attention, and schizotypal personality symptoms in nonpsychotic relatives of patients with schizophrenia. Archives of General Psychiatry, 1997; 54: 169-176.

Keefe RSE, Fenton WS. How should DSM-V criteria for schizophrenia include cognitive impairment? Schizophrenia Bulletin, 2007; 33: 912-920.

Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RSE, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. New England Journal of Medicine, 2005; 353: 1209-1223.

Keefe RSE, Perkins DO, Gu H, Zipursky RB, Christensen BK, Lieberman JA. A longitudinal study of neurocognitive function in individuals at-risk for psychosis. Schizophrenia Research 2006; 88: 26-35.

Keefe RSE, Bilder RM, Davis SM, Harvey PD, Palmer BW, Gold JM, Meltzer HY, Green MF, Capuano G, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Davis CE, Hsiao JK, and Lieberman JA for the CATIE Investigators and the Neurocognitive Working Group. Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE trial. Archives of General Psychiatry, 2007; 64: 633-647.

Keefe RSE, Harvey PD. Implementation considerations for multi-site clinical trials with cognitive neuroscience tasks. Schizophr Bull, 2008; 34: 656-663.

Keefe RSE, Kraus MS. Measuring memory-prediction errors and their consequences in youth at risk for schizophrenia. Annals of the Academy of Medicine, Singapore, 2009; 38:

414-416.

Krishnan RR, Keefe R, Kraus M. Schizophrenia is a disorder of higher order hierarchical processing. Medical Hypotheses, 2009; 72: 740-744

Marx CE, Keefe RSE, Buchanan RW, Hamer RM, Kilts JD, Bradford DW, Strauss JL, Naylor JC, Payne VM, Lieberman JA, Savitz AJ, Leimone LA, Dunn L, Porcu P, Morrow AL, Shampine LJ. Proof-of-Concept Trial with the neurosteroid pregnenlone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology, 2009; 34: 1885-1903.

Keefe RSE, Vinogradov S, Medalia A, Silverstein SM, Bell MD, Dickinson D, Ventura J, Marder SR, Haim A, Stroup TS. Report from the Working Group Conference on multi-site trial design for cognitive remediation in schizophrenia. Schizophrenia Bulletin, in press.