Li, Ting-Kai

Research Interests:

My principal research interest is alcohol use disorder (abuse and dependence) and its attendant health risks, behavioral comorbidities and gene-environment interplay in their genesis. I have done research in the genetic basis of individual differences to alcohol metabolism and behavioral responses to alcohol (reinforcement, tolerance and dependence). I have developed genetic animal models of alcohol-seeking behavior to study the biological basis of differences in responses to alcohol and its metabolites (acetaldehyde and acetate).

Selected Publications:

Crabb DW, Edenberg HJ, Bosron WF and Li T-K (1989) Genotyypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2*2 allele is dominant. J Clin Invest 83: 314-316.

Li, T-K (2000) Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking. J Stud Alcohol 61: 5-12.

McBride WJ, Li, T-K (1998) Animal models of alcoholism: neurobiology of high alcohol drinking behavior. Crit Rev Neurobiol 12: 339-369.

Carr LG, Foroud T, Stewart T, Castellucio P, Edenberg HJ and Li T-K (2002) Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population. Amer J Med Genet 112: 138-143.

Hurley TD, Edenberg HJ, Li T-K (2002) Pharmacogenomics of alcoholism. Pharacogenomics: The Search for Individual Therapies. Eds Julio Licinio and Ma-Li Wong. Wiley-VCH pp 417-441.

Murphy JM, Stewart RB, Bell RL, Elder NE, Carr LG, McBride WJ, Lumeng L, Li T-K (2002) Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. Behav Genet 32: 363-388.

Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, Li T-K, McBride WJ (2003) Effects of repeated alcohol deprivation on operant ethanol self-administration by alcohol preferring P rats. Neuropsychopharmacology 28: 1614-1621.

Li, T-K (2008) Quantifying the risk for alcohol-use and alcohol-attributable health disorders: present findings and future research needs. J Gastroenterology and Hepatology 23 (Suppl. 1) S2-S8.

Brooks PJ, Enoch MA, Goldman D, Li T-K & Yokoyama A (2009) The alcohol flush response: an unrecognized risk factor for esophageal cancer from alcohol consumption. Vol 6 No3; e100050.