Smith, Gavin JD

Research Interests:

My major research focus is on the ecology, genetic and antigenic evolution, population dynamics, molecular epidemiology and interspecies transmission of emerging infectious diseases, particularly respiratory viruses. My research is directed at efforts to better understand the disease ecosystem in Asia, specifically the animal-human interface, to inform and enhance disease control.

Selected Publications:

Bahl J, Nelson MI, Chan KH, Chen R, Vijaykrishna D, Halpin RA, Stockwell TB, Lin X, Wentworth DE, Ghedin E, Guan Y, Peiris JSM, Riley S, Rambaut A, Holmes EC, Smith GJD (2011). Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. Proceedings of the National Academy of Sciences USA (in press).

Vijaykrishna D, Smith GJD, Pybus OG, Zhu H, Bhatt S, Poon LLM, Riley S, Bahl J, Ma SK, Cheung CL, Perera RAPM, Chen H, Shortridge KF, Webby RJ, Webster RG, Guan Y, Peiris JSM (2011). Long-term evolution and transmission dynamics of swine influenza A virus. Nature 473, 519–522.

Ducatez MF, Bahl J, Griffin Y, Stigger-Rosser E, Franks J, Barman S, Vijaykrishna D, Webb A, Guan Y, Webster RG, Smith GJD, Webby RJ (2011). Feasibility of reconstructed ancestral H5N1 influenza viruses for cross-clade protective vaccine development. Proceedings of the National Academy of Sciences USA 108: 349–354.

Vijaykrishna D, Poon LLM, Zhu HC, Ma SK, Li OTW, Cheung CL, Smith GJD, Peiris JSM, Guan Y (2010). Reassortment of pandemic H1N1/2009 influenza A virus in swine. Science 328: 1529.

Smith GJD, Bahl J, Vijaykrishna D, Zhang JX, Poon LLM, Chen H, Webster RG, Peiris JSM, Guan Y (2009). Dating the emergence of pandemic influenza viruses. Proceedings of the National Academy of Sciences USA 106:11709–11712.

Smith GJD, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus OG, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JSM, Guan Y, Rambaut A (2009). Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459: 1122–1125.

Vijaykrishna D, Bahl J, Riley S, Duan L, Zhang J, Chen H, Peiris JSM, Smith GJD, Guan Y (2008). Evolutionary dynamics and emergence of panzootic H5N1 influenza viruses. PLoS Pathogens 4: e1000161.

Smith GJD, Fan XH, Wang J, Li KS, Qin K, Zhang JX, Vijaykrishna D, Cheung CL, Huang K, Rayner JM, Peiris JSM, Chen H, Webster RG, Guan Y (2006). Emergence and predominance of an H5N1 influenza variant in China. Proceedings of the National Academy of Sciences USA 103: 16936–16941.

Chen H, Smith GJD, Zhang SY, Qin K, Wang J, Li KS, Webster RG, Peiris JSM, Guan Y (2005). Avian flu: H5N1 virus outbreak in migratory waterfowl. Nature 436:191–192

Li KS, Guan Y, Wang J, Smith GJD, Xu KM, Duan L, Rahardjo AP, Puthavathana P, Buranathai C, Nguyen TD, Estoepangestie AT, Chaisingh A, Auewarakul P, Long HT, Hanh NT, Webby RJ, Poon LL, Chen H, Shortridge KF, Yuen KY, Webster RG, Peiris JSM (2004). Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 430: 209–213.