Solter, Davor

Research Interests:

Davor Solter contributed significantly to many areas of mammalian developmental biology, namely: differentiation of germ layers; role of cell surface molecules in regulating early development; biology and genetics of teratocarcinoma; biology of embryonic stem cells; imprinting and cloning. His current research interest focuses on genetic and epigenetic mechanism regulating preimplantation mouse development and reprogramming in human embryonic stem cells.

Selected Publications:

Solter, D. 2006. From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research. Nat. Rev. Genet. 7: 319-327.

Motosugi, N., Dietrich, J.-E., Polanski, Z., Solter, D., and Hiiragi, T. 2006. Space asymmetry directs preferential sperm entry in the absence of polarity in the mouse oocyte. PloS Biology 4: e135.

Solter, D. 2005. Politically correct human embryonic stem cells? N. Engl. J. Med. 353: 2321-2323.

Motosugi, N., Bauer, T., Polanski, Z., Solter, D., and Hiiragi, T. 2005. Polarity of the mouse embryo is established at blastocyst and is not prepatterned. Genes Dev. 19: 1081-1092.

Kemler, R., Hierholzer, A., Kanzler, B., Kuppig, S., Hansen, K., Taketo, M.M., de Vries, W.N., Knowles, B.B., and Solter, D. 2004. Stabilization of -catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development 131: 5817-5824.

Solter, D., Hiiragi, T., Evsikov, A.V., Moyer, J., de Vries, W.N., Peaston, A.E., and Knowles, B.B. 2004. Epigenetic mechanisms in early mammalian development. Cold Spring Harbor Symposia on Quantitative Biology 69: 11-17.

Hiiragi, T. and Solter, D. 2004. First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing nuclei. Nature 430: 360-364.

Solter, D., Beyleveld, D., Friele, M.B., Holowka, J., Lilie, H., Lovell-Badge, R., Mandla, C., Martin, U. and Pardo Avellaneda, R. Embryo Research in Pluralistic Europe, Springer-Verlag, Berlin, 2003.

Solter, D. 2000. Mammalian cloning: advances and limitations. Nat. Rev. Genet. 1: 199-207.

Solter, D. 1988. Differential imprinting and expression of maternal and paternal genomes. Ann. Rev. Genet. 22: 127-146.