Tan, Patrick

Research Interests:

Genomic Oncology of Gastric Cancer

Our research group seeks to apply genomic technologies and information to address biological questions in cancer. Our work is primarily focused on the genomic characterization of gastric cancer (GC), the second leading cause of global cancer mortality. At present, relatively little is known about the specific oncogenic pathways that regulate different aspects of the gastric cancer phenotype. We hope to identify and understand these pathways, and ultimately use this knowledge to define rational therapeutic strategies for gastric cancer patients. Our group is also a key party in the Singapore Gastric Cancer Consortium. Some of our previous achievements include

a) Using a combination of array-based comparative genomic hybridization and expression profiling to show that gastric cancers can be subdivided into distinct molecular subtypes which distinct clinical outcomes (Tay et al., 2003);

b) Formation of an international Gastric Cancer Consortium comprising members from Australia, Hong Kong, Japan, and Singapore, to pool expression data from >300 gastric tissues to determine conserved gene expression networks in GC (Aggarwal et al., 2006);

c) Identification of the gene PLA2G2A as a novel metastasis regulator in GC (Ganesan et al., 2008).

In addition to our work on GC, we also support and collaborate with many other cancer researchers on other cancers include lung, liver, and breast cancer. In addition, we also have a complementary research group at the Genome Institute of Singapore (www.gis.a-star.edu.sg) focused on microbial genomics of the Gram-negative pathogen Bukholderia pseudomallei.

Selected Publications:

Nallasivam Palanisamy, Bushra Ateeq, Shanker Kalyana-Sundaram, Dorothee Pflueger, Kalpana Ramnarayanan, Sunita Shankar, Bo Han, Qi Cao, Xuhong Cao, Khalid Suleman, Chandan Kumar-Sinha, Saravana M. Dhanasekaran, Ying-bei Chen, Raquel Esgueva, Samprit Banerjee, Christopher J. LaFargue, Javed Siddiqui, Francesca Demichelis, Peter Moeller, Tarek A. Bismar, Rainer Kuefer, Douglas R. Fullen, Timothy M. Johnson, Joel K. Greenson, Thomas J. Giordano ,Patrick Tan, Scott A. Tomlins, Sooryanarayana Varambally, Mark A. Rubin, Christopher A. Maher, & Arul M. Chinnaiyan (2010) Rearrangements of the RAF Kinase Pathway in Prostate Cancer, Gastric Cancer and Melanoma. Nature Medicine 16(7):793-8

Chia Huey Ooi, Tatiana Ivanova, Jeanie Wu, Minghui Lee, Iain Beehuat Tan, Jiong Tao, Lindsay Ward, Jun Hao Koo, Veena Gopalakrishnan, Yansong Zhu, Lai Ling Cheng, Julian Lee, Sun Young Rha, Hyun Cheol Chung, Kumaresan Ganesan, Jimmy So, Khee Chee Soo, Dennis Lim, Weng Hoong Chan, Wai Keong Wong, David Bowtell, Khay Guan Yeoh, Heike Grabsch, Alex Boussioutas, and Patrick Tan (2009) Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer. PLOS Genetics doi:10.1371/journal.pgen.100676

Philippe Broët, Sophie Camilleri-Broët, Shenli Zhang, Marco Alifano, Dhinoth Bangarusamy, Maxime Battistella, Yonghui Wu, Marianne Tuefferd, Jean-François Régnard, Elaine Lim, Patrick Tan*, Lance D. Miller* (2009) Prediction of Clinical Outcome in Multiple Lung Cancer Cohorts By Integrative Genomics : Implications for Chemotherapy Selection. Cancer Research, 69(3):1055–62 (* = Equal Contributorship) (Cited on Journal Cover)

Sooryanarayana Varambally, Qi Cao, Ram-Shankar Mani, Sunita Shankar, Xiaosong Wang, Bushra Ateeq, Bharathi Laxman, Xuhong Cao, Xiaojun Jing, Kalpana Ramnarayanan, J. Chad Brenner, Jindan Yu, Jung H. Kim, Bo Han, Patrick Tan, Chandan Kumar-Sinha, Robert J. Lonigro, Nallasivam Palanisamy, Christopher A. Maher, and Arul M. Chinnaiyan (2008) Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer. Science 322: 1695-1699

Kun Yu, Kumaresan Ganesan, Lay Keng Tan, Mirtha Laban, Jeanie Wu, Xiao Dong Zhao, Hongmin Li, Carol Ho Wing Leung, Yansong Zhu, Chia Lin Wei, Shing Chuan Hooi, Lance Miller, Patrick Tan (2008) A Precisely Regulated Gene Expression Cassette Potently Modulates Metastasis and Survival in Multiple Solid Cancers. PLoS Genetics. 4(7): e1000129.

Qingsong Hou, Yong Hui Wu, Heike Grabsch, Yansong Zhu, Siew Hong Leong, Kumaresan Ganesan, Debra Cross, Lay Keng Tan, Jiong Tao, Veena Gopalakrishnan, Bor Luen Tang, Oi Lian Kon, Patrick Tan. (2008) Integrative Genomics Identifies RAB23 as an Invasive Mediator Gene in Diffuse Gastric Cancer. Cancer Res 68: 4623-4630.

Kumaresan Ganesan, Tatiana Ivanova, Yonghui Wu, Vikneswari Rajasegaran, Jeanie Wu, Ming Hui Lee, Kun Yu, Sun Young Rha, Hyun Cheol Chung, Bauke Ylstra, Gerrit Meijer, Kon Oi Lian, Heike Grabsch, and Patrick Tan. (2008) Inhibition of Gastric Cancer Invasion and Metastasis by PLA2G2A, a Novel ß-catenin/TCF Target Gene. Cancer Res. 68(11):4277-4286.

Jing Tan, Xiaojing Yang, Li Zhuang, Xia Jiang, Wei Chen, RK Murthy Karuturi, Patrick Boon Ooi Tan, Edison T. Liu and Qiang Yu (2007) Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 21, 1050-1063

Amit Aggarwal, Dong Li Guo, Yujin Hoshida, Siu Tsan Yuen, Kent-Man Chu, Samuel So, Alex Boussioutas, Xin Chen, David Bowtell, Hiroyuki Aburatani, Suet Yi Leung, and Patrick Tan (2006) Topological and Functional Discovery in a Gene Co-expression Meta-Network of Gastric Cancer, Cancer Research 66, 232-241 (cited on journal cover)

Aggarwal Amit, Siew Hong Leong, Cheryl Lee, Oi Lian Kon, Patrick Tan (2005) Wavelet Transformations of Tumor Expression Profiles Reveals a Pervasive Genome Wide Imprinting of Aneuploidy on the Cancer Transcriptome. Cancer Research 65, 186-194

Kun Yu, Chee How Lee, Puay Hoon Tan, Ga Sze Hong, Siew Bok Wee, Chow Yin Wong, and Patrick Tan (2004) A Molecular Signature of the Nottingham Prognostic Index in Breast Cancer, Cancer Research 64, 2962-2968 (Advances in Brief)

Tay ST, Leong SH, Yu K, Aggarwal A, Tan SY, Lee CH, Wong K, Visvanathan J, Lim D, Wong WK, Soo KC, Kon OL, Tan P (2003) A Combined Comparative Genomic Hybridization and Expression Microarray Analyses of Gastric Cancer Reveals Novel Molecular Subtypes, Cancer Research, 63, 3309-3316