Zhou, Juan Helen

Research Interests:

Our lab studies the human neural bases of social-emotion, cognition, and memory functions and the associated vulnerability patterns in neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), Schizophrenia, and dementia. Multimodal neuroimaging and psychophysical techniques are employed, including magnetic resonance imaging (MRI), functional brain MRI, diffusion tensor imaging, and electroencephalography (EEG). We are interested in examining the network-level structural and functional brain connectivity in the healthy developing and aging brain to predict behaviour and maturation. We will integrate longitudinal behaviour, neuroimaging, and genotype data by statistical or computational methods. Applying to neuropsychological disorders, our goal is to investigate the interactions among brain network dynamics, behaviours, diseases, and genotypes to develop non-invasive biomarkers for differential diagnosis, disease monitoring, and treatment design.

Selected Publications:

Zhou J, Gennatas ED, Kramer JH, Miller BL, Seeley WW. Predicting regional neurodegeneration from the healthy brain functional connectome. Neuron, 2012; 73: 1216-1227 (COVER).

Gennatas ED, Cholfin JA, Zhou J, Crawford RK, Sasaki DA, Karydas AM, Boxer AL, Bonasera SJ, Rankin KP, Gorno-Tempini ML, Rosen HJ, Kramer J, Weiner M, Miller BL, Seeley WW. COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures. Neurology, 2012 (in press).

Seeley WW, Zhou J, Kim EJ. Frontotemporal dementia: What can the behavioral variant teach us about human brain organization? Neuroscientist, 2011; June 13.

Imperati D, Colcombe S, Kelly C, Di Martino A, Zhou J, Castellanos FX, and Milham MP. Differential development of human brain white matter tracts. PLOS One (in press).

Au WL, Zhou J, Palmes P, Sitoh YY, Tan LCS, Rajapakse JC. Levodopa and the feedback process on set-shifting in Parkinson’s disease. Human Brain Mapping, 2011; March 24, 1-13.

Zhou J, Greicius MD, Gennatas ED, Growdon ME, Jang JY, Rabinovici GD, Kramer JH, Weiner M, Miller BL, Seeley WW. Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease. Brain 2010; 133(5): 1352-67.

Zielinski BA, Gennatas ED, Zhou J, Seeley WW. Network-level structural covariance in the developing brain. Proceedings of the National Academy of Sciences, USA, 2010; 107(42): 18191-18196.

Rohrer JD, Geser F, Zhou J, Gennatas ED, Sidhu M, Trojanowski JQ, DeArmond SJ, Miller BL, Seeley WW. Neurology, 2010; 75(24: 2204-11.

Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD. Neurodegenerative diseases target large-scale human brain networks. Neuron 2009; 62(1): 42-52 (COVER ARTICLE).

Rajapakse JC, Wang Y, Zheng X, Zhou J. Probabilistic framework for brain connectivity from functional MR images. IEEE Transactions on Medical Imaging 2008; 27(6): 825-33.

Zhou J. and Rajapakse JC. Fuzzy approach to incorporate hemodynamic variability and contextual information for detection of brain activation. Neurocomputing 2008; 71(16-18): 3184-92.

Rajapakse JC, Zhou J. Learning effective brain connectivity with dynamic Bayesian networks. NeuroImage 2007; 37(3): 749-60.

Zhou J, Rajapakse JC. Segmentation of subcortical brain structures using fuzzy templates. NeuroImage 2005; 28(4): 915-24.