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NEUROSC Regular Faculty



Nagaendran Kandiah

Associate Professor

Senior Consultant, Department of Neurology, National Neuroscience Institute

Director, Clinical Research, Neuroscience Academic Clinical Programme

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Education Qualifications: MBBS, FRCP (Edinburgh), FAMS (Neurology)

Dr Nagaendran Kandiah is a Senior Consultant neurologist and the Director of the NNI Dementia Programme. He holds a Clinician Scientist position with the National Medical Research Council of Singapore. His research interest includes Mild Cognitive Impairment, Role of Cerebrovascular disease in Alzheimer’s dementia, Parkinson’s disease dementia and Frontotemporal Dementia. He holds several national grants investigating these research areas and has published extensively in this field. He is also actively involved in the training aspects of dementia and is currently the chairman of the Neurocognitive and Research Training Consortium of Southeast Asia (NRTC-SEA). From a clinical perspective he has vast experience in the diagnosis and management of Alzheimer’s disease, Vascular dementia, Frontotemporal Dementia, Autoimmune Dementia and other related dementias.  He leads the Singapore Ministry of Health initiative on Comprehensive Young Onset Dementia Programme. He is also the chairman of the Ministry of Health Clinical Practice Guidelines on Dementia.

 

Professional Appointments and Committee Memberships: 

  • Clinician Scientist, National Medical Research Council, Singapore
  • Clinical Lecturer, Yong Loo Lin Medical School, National University of Singapore
  • Chairman, Chapter of Neurology, Academy of Medicine
  • Director, National Neuroscience Institute Dementia Programme
  • Assistant Director, Clinical Research, National Neuroscience Institute
  • Chairman, Clinical Practice Guidelines for Dementia 2013-2017, Ministry of Health, Singapore
  • Chairman, Neurocognitive and Research Training Consortium, Southeast Asia (NRTC-SEA)
  • Board Member, Asian Society Against Dementia
  • Director of Education, Vas-Cog Society, Asia
  • Panel Member, Open Fund-Young Individual Research Grant, National Medical Research Council
  • Panel Member, Academic Clinical Programme (ACP) Research Support Programme

Awards:

  • SingHealth Publish Award (Neurology), 2014
  • SingHealth Academy Golden Apple Awards for Program Innovation Award, 2011

Selected Publications:

Association of Asymmetrical White Matter Hyperintensities and Apolipoprotein E4 on Cognitive Impairment. Low A, Ng KP, Chander RJ, Wong B, Kandiah N.J Alzheimers Dis. 2019 Jul 5. doi: 10.3233/JAD-190159

Medial Temporal Atrophy in Amyloid-Negative Amnestic Type Dementia Is Associated with High Cerebral White Matter Hyperintensity. Wong BYX, Yong TT, Lim L, Tan JY, Ng ASL, Ting SKS, Hameed S, Ng KP, Zhou JH, Kandiah N. J Alzheimers Dis. 2019;70(1):99-10

Cerebrovascular Disease Is a Risk for Getting Lost Behavior in Prodromal Dementia. Yatawara C, Ng KP, Lim L, Chander R, Zhou J, Kandiah N. Am J Alzheimers Dis Other Demen. 2019 Aug;34(5):344-352. doi: 10.1177/1533317519852864. Epub 2019 May 29.

Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Wilson D, …, Kandiah N,….Werring DJ; Microbleeds International Collaborative Network. Lancet Neurol. 2019 Jul;18(7):653-665. doi: 10.1016/S1474-4422(19)30197-8. Epub 2019 May 23. 

Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Gallart-Palau X, Tan LM, Serra A, Gao Y, Ho HH, Richards AM, Kandiah N, Chen CP, Kalaria RN, Sze SK. Ageing Res Rev. 2019 May 19;53:100909. doi: 10.1016/j.arr.2019.100909.

Construct validity of the Visual Cognitive Assessment Test (VCAT)-a cross-cultural language-neutral cognitive screening tool. Low A, Lim L, Lim L, Wong B, Silva E, Ng KP, Kandiah N. Int Psychogeriatr. 2019 May 21:1-9. doi: 10.1017/S1041610219000504

Mechanisms Linking White Matter Lesions, Tract Integrity, and Depression in Alzheimer Disease. Yatawara C, Lee D, Ng KP, Chander R, Ng D, Ji F, Shim HY, Hilal S, Venketasubramanian N, Chen C, Zhou J, Kandiah N. Am J Geriatr Psychiatry. 2019 Apr 18. pii: S1064-7481(19)30337-9. doi: 10.1016/j.jagp.2019.04.004. 

Light-Induced Pupillary Responses in Alzheimer's Disease. Chougule PS, Najjar RP, Finkelstein MT, Kandiah N, Milea D. Front Neurol. 2019 Apr 12;10:360. doi: 10.3389/fneur.2019.00360. eCollection 2019. Review.

DTI Profiles for Rapid Description of Cohorts at the Clinical-Research Interface. Lock C, Kwok J, Kumar S, Ahmad-Annuar A, Narayanan V, Ng ASL, Tan YJ, Kandiah N, Tan EK, Czosnyka Z, Czosnyka M, Pickard JD, Keong NC. Front Med (Lausanne). 2019 Jan 10;5:357. doi: 10.3389/fmed.2018.00357. eCollection 2018.

Hippocampal subfield atrophy of CA1 and subicular structures predict progression to dementia in idiopathic Parkinson's disease. Low A, Foo H, Yong TT, Tan LCS, Kandiah N. J Neurol Neurosurg Psychiatry. 2019 Jun;90(6):681-687. doi: 10.1136/jnnp-2018-319592.

Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761®.Kandiah N, Ong PA, Yuda T, Ng LL, Mamun K, Merchant RA, Chen C, Dominguez J, Marasigan S, Ampil E, Nguyen VT, Yusoff S, Chan YF, Yong FM, Krairit O, Suthisisang C, Senanarong V, Ji Y, Thukral R, Ihl R. CNS Neurosci Ther. 2019 Feb;25(2):288-298. doi: 10.1111/cns.13095.

Serial position effects differ between Alzheimer's and vascular features in mild cognitive impairment. Chander RJ, Foo H, Yong T, Lim L, Tan J, Wen MC, Ng A, Hameed S, Ting S, Zhou J, Kandiah N. Aging (Albany NY). 2018 Dec 12;10(12):3866-3880

Regional White Matter Hyperintensity Influences Grey Matter Atrophy in Mild Cognitive Impairment. Vipin A, Foo HJL, Lim JKW, Chander RJ, Yong TT, Ng ASL, Hameed S, Ting SKS, Zhou J, Kandiah N. J Alzheimers Dis. 2018;66(2):533-549. doi: 10.3233/JAD-180280.

The influence of language and culture on cognitive assessment tools in the diagnosis of early cognitive impairment and dementia.Ng KP, Chiew HJ, Lim L, Rosa-Neto P, Kandiah N, Gauthier S. Expert Rev Neurother. 2018 Nov;18(11):859-869. doi: 10.1080/14737175.2018.1532792. Epub 2018 Oct 10.

Mapping the Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory to the Health Utility Index Mark III. Cheung YB, Tan HX, Wang VW, Kandiah N, Luo N, Koh GCH, Wee HL.Qual Life Res. 2019 Jan;28(1):131-139. doi: 10.1007/s11136-018-1991-4.

Associations between lesions and domain-specific cognitive decline in poststroke dementia. Yatawara C, Ng KP, Chander R, Kandiah N. Neurology. 2018 Jul 3;91(1):e45-e54. doi: 10.1212/WNL.0000000000005734. Epub 2018 May 25.

Targeted exome sequencing reveals homozygous TREM2 R47C mutation presenting with behavioral variant frontotemporal dementia without bone involvement. Ng ASL, Tan YJ, Yi Z, Tandiono M, Chew E, Dominguez J, Macas M, Ng E, Hameed S, Ting S, Tan EK, Foo JN, Kandiah N. Neurobiol Aging. 2018 Aug;68:160.e15-160.e19.

A novel language-neutral Visual Cognitive Assessment Test (VCAT): validation in four Southeast Asian countries.Lim L, Ng TP, Ong AP, Tan MP, Cenina AR, Gao Q, Ng A, Kandiah N. Alzheimers Res Ther. 2018 Jan 22;10(1):6. doi: 10.1186/s13195-017-0333-z.

Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease. Ng ASL, Ng EYL, Tan YJ, Kandiah N, Zhou J, Hameed S, Ting SKS, Tan EK. Neurobiol Aging. 2018 Apr;64:157.e7-157.e9. doi: 10.1016/j.neurobiolaging.2017.11.012. 

Getting Lost Behavior in Patients with Mild Alzheimer's Disease: A Cognitive and Anatomical Model. Yatawara C, Lee DR, Lim L, Zhou J, Kandiah N.Front Med (Lausanne). 2017 Nov 16;4:201. doi: 10.3389/fmed.2017.00201. eCollection 2017.