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A Morning with Sterol Stars (Prof Peter Tontonoz, MD, PhD): Lipid Metabolism In Physiology And Disease
ABOUT THE LECTURE:Control of cellular and systemic lipid levels is critical for organismal homeostasis. Lipid-responsive transcription factors including PPARs, LXRs and SREBPs play important roles in coordinating gene expression in response to changes in cellular lipid levels. Together these transcriptional networks ensure the proper synthesis, transport, storage and efflux of cholesterol, fatty acids and phospholipids. Recent studies in our group have characterized new cellular effectors regulated by LXRs and PPARg that participate directly in lipid transport and storage. Define the molecular mechanisms by which cells control the availability and utilization of different lipid species is critical for understanding physiology and has implications for human diseases including obesity, diabetes and atherosclerosis.
HOST:
Prof David Lawrence Silver
Deputy Director
Programme in Cardiovascular & Metabolic Disorders
Duke-NUS Medical School
DATE:
Wednesday, 15 March 2023
TIME:
12:00PM - 1:00PM
VENUE:
For in-person attendance:
Duke-NUS Medical School
Amphitheatre, Level 2
For virtual seminar (via Zoom), please register HERE.
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CONTACT PERSON:
Ms Serene Wie (serene.wie@duke-nus.edu.sg)
Duke-NUS Research Affairs Department
Date and Time
15 Mar 2023 @ 12:00 - 15 Mar 2023 @ 13:00
Speaker
Prof Peter Tontonoz, MD, PhD
Professor of Pathology and Biological Chemistry
Francis and Albert Piansky Chair
University of California, Los Angeles
ABOUT THE SPEAKER:
Dr. Tontonoz received his B.A. from Wesleyan University and his M.D. and Ph.D. from Harvard Medical School. His group has elucidated pathways for the control of lipid uptake, transport and efflux, and has shown how these pathways impact metabolic tissues in both physiology and disease. Dr. Tontonoz has an h-index of 109 and his work has been cited more than 64,000 times. He is a member of the National Academy of Sciences and the National Academy of Medicine.