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Wu Yang


Wu Yang (Steve Rozen’s Team)

Wu Yang is a bioinformatician with strong interest in applying sequencing, bioinformatic, and experimental technologies to translational cancer research. This includes cancer subtyping and profiling, unveiling mechanisms of cancer development and poor prognosis, cancer mutational signature analyses, early detection, finding therapeutic targets and developing novel therapies.



  1. Liu, M., Y. Wu, N. Jiang, A. Boot and S. G. Rozen (2022). "mSigHdp: hierarchical Dirichlet process mixture modeling for mutational signature discovery." bioRxiv: 2022.2001.2031.478587.
  2. Wu, Y., E. H. Z. Chua, A. W. T. Ng, A. Boot and S. G. Rozen (2022). "Accuracy of mutational signature software on correlated signatures." Scientific Reports 12(1): 390.
  3. Islam, S. M. A., Y. Wu, M. Díaz-Gay, E. N. Bergstrom, Y. He, M. Barnes, M. Vella, J. Wang, J. W. Teague, P. Clapham, S. Moody, S. Senkin, Y. R. Li, L. Riva, T. Zhang, A. J. Gruber, R. Vangara, C. D. Steele, B. Otlu, A. Khandekar, A. Abbasi, L. Humphreys, N. Syulyukina, S. W. Brady, B. S. Alexandrov, N. Pillay, J. Zhang, D. J. Adams, I. Martincorena, D. C. Wedge, M. T. Landi, P. Brennan, M. R. Stratton, S. G. Rozen and L. B. Alexandrov (2021). "Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor." bioRxiv: 2020.2012.2013.422570.
  4. Alexandrov, L. B., J. Kim, N. J. Haradhvala, M. N. Huang, A. W. T. Ng, Y. Wu, A. Boot, K. R. Covington, D. A. Gordenin, E. N. Bergstrom, S. M. A. Islam, N. Lopez-Bigas, L. J. Klimczak, J. R. McPherson, S. Morganella, R. Sabarinathan, D. A. Wheeler, V. Mustonen, G. Getz, S. G. Rozen, M. R. Stratton and P. Consortium (2020). "The repertoire of mutational signatures in human cancer." Nature 578(7793): 94-101.