Hui, Kam Man

Adjunct Professor

Cancer & Stem Cell Biology Programme

Other Affiliations:

Adjunct Professor, National University of Singapore, Dept of Biochemistry, Yong Loo Lin School of Medicine
Adjunct Research Director, Institute of Molecular and Cell Biology, A*STAR, Biopolis, Singapore;
Adjunct Senior Investigator, Singapore Bioimaging Consortium (SBIC), A*STAR, Biopolis, Singapore.

Email 1:

cmrhkm@nccs.com.sg

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Research

Research Interest:

Our laboratory aims to develop a better understanding of the processes of liver carcinogenesis in human hepatocellular carcinoma, focuses on expression profiles-based molecular genetic studies.

Specifically,

1. We perform functional genomic studies to decipher the molecular differences between cancerous and normal liver tissues to identify novel diagnostic and prognostic biomarkers relating to human hepatocellular carcinoma.

2. To better understand the molecular roles of these biomarkers in the carcinogenesis of human hepatocellular carcinoma.

3. To design and build novel diagnostic platforms for human hepatocellular carcinoma using these novel biomarkers.

4. To design and perform animal experimentation to validate novel viral- and drug-mediated therapies for human hepatocellular carcinoma.

5. To design and generate cancer-specific vaccines for human hepatocellular carcinoma.

Selected Publications:

1. A blood-based 3-gene signature for the non-invasive detection of early human hepatocellular carcinoma. Ming Shi, Min-Shan Chen, Karthik Sekar, Chee-Kiat Tan, London Lucien Ooi and Kam M Hui. European Journal of Cancer. In press. Dec 11, 2013.

2. Systemically delivered measles virus-infected mesenchymal stem cells can evade host immunity to inhibit liver cancer growth. Ong HT, Federspiel MJ, Guo CM, Lucien Ooi L, Russell SJ, Peng KW, Hui KM. Journal of Hepatology 2013 Nov;59(5):999-1006.

3. A paper-based microfluidic electrochemical immunodevice integrated with amplification-by-polymerization for the ultrasensitive multiplexed detection of cancer biomarkers. Yafeng Wu, Peng Xue, Kam M Hui, Yuejun Kang. (Joint corresponding author). Biosensors and Bioelectronics, 2014 Feb 15;52:180-7.

4. A paper-based microfluidic electrochemical immunodevice integrated with nanobioprobes onto graphene film for ultrasensitive multiplexed detection of cancer biomarkers. Wu, Yafeng; Peng, Xue; Kang, Yuejun; and Kam M. Hui. Anal. Chem 2013 Sep 17; 85(18):8661-8.

5. MiR-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. Xia H, Ooi LL, Hui KM. Hepatology. 2013;58:629-641.

6. Highly specific and ultrasensitive graphene-enhanced electrochemical detection of low-abundance tumor cells using silica nanoparticles coated with antibody-conjugated quantum dots. Wu Y, Xue P, Kang Y, Hui KM. Anal Chem. 2013 Mar 19;85(6):3166-73.

7. Potential role of signal transducer and activator of transcription (STAT)3 signaling pathway in inflammation, survival, proliferation and invasion of hepatocellular carcinoma. Subramaniam A, Shanmugam MK, Perumal E, Li F, Nachiyappan A, Dai X, Swamy SN, Ahn KS, Kumar AP, Tan BK, Hui KM, Sethi G. (Joint corresponding author). Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2013 Jan;1835(1):46-60.

8. MicroRNAs involved in regulating epithelial-mesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics. Xia H, Hui KM. Cancer Gene Ther. 2012 Nov;19(11):723-30.

9. MiR-214 targets β-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma. Xia H, Ooi LL, Hui KM. PLoS One. 2012;7(9):e44206.

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Hui, Kam Man

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Duke-NUS Medical School

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