Lee, Tih-Shih

MD, PhD, FRCP(C). FRCP(Edin.)

Associate Professor

Neuroscience & Behavioural Disorders Programme

Other Affiliations:

Associate Professor of Psychiatry and Behavioral Sciences, Duke University

Senior Consultant, Singapore General Hospital

+65 6516 7461

+65 6534 7461

Email 1:

tihshih.lee@duke-nus.edu.sg

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Research

Research Interest:

His research interests are in genomic and molecular investigations of human neuropsychiatric disorders, specifically human temporal lobe epilepsy, schizophrenia and longitudinal transcriptomics of Alzheimer's disease. He has a separate research program on Brain-Computer Interface (BCI) technologies with co-investigators at I2R (ASTAR) focusing on cognitive interventions for neuropsychiatric conditions e.g. Attention-Deficit Hyperactivity Disorder in children and memory loss in the elderly.

In addition to his academic and research roles in Duke University Medical School/Duke-NUS Medical School, he is also a Senior Consultant in Singapore General Hospital. His areas of specific clinical interests are in complex brain disorders, e.g. neuropsychiatric autoimmune disorders, functional neuropsychiatric disorders and atypical types of dementia.

Selected Publications:

Lee T, Eid T, Mane S, Kim J, Spencer D, Ottersen O, de Lanerolle N. Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy. Acta Neuropathol. 2004 Dec;108(6):493-502

Eid T, Lee T (joint first authors), Thomas MJ, Amiry-Moghaddam M, Bjornsen LP, Spencer DD, Agre P, Ottersen OP, de Lanerolle NC. Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus. Proc Natl Acad Sci USA 2005 Jan 25;102(4):1193-8.

De Lanerolle, N, Lee, T. New Facets of the Neuropathology and Molecular Profile of Human Temporal Lobe Epilepsy, Epilepsy and Behavior, 2005, Sep: 2: 190-203.

Lee, T, Bjornsen, L, Paz, C, Kim, J, Spencer, S, Spencer, D, Eid, T, de Lanerolle, N.GAT1 and GAT3 expression are difffently localized in the human epileptogenic hippocampus. Acta Neuropathol. 2006 Feb 3;1-13

Eid T, Hammer J, Runden-Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC. Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy. Acta Neuropathol. 2007 Feb;113(2):137-52.

Lee T, Mane S, Tore E, Zhao H, Lin A, Schweitzer J, King-Stephens D, Weber P, Spencer S, Spencer D, de Lanerolle N. Gene Expression in Human Temporal Lobe Epilepsy is consistent with Increased Release of Glutamate by Astrocytes. Mol Med. 2007 Jan-Feb. 13(1-2)1-13.

Lee T, Ng BY, Lee WL. Neuropsychiatry: An Emerging Field. Ann Acad Med Singapore. 2008 Jul;37(7):601-5.

Tore E, Ghosh A, Wang Y, Henning B, Hitten P. Zaveri, Lee T, Lai J, Malthankar-Phatak G, de Lanerolle N. Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats. Brain. 2008 Aug;131(Pt 8):2061-70.

Eid T, Williamson A, Lee T, Petroff O, de Lanerolle N. Glutamate and Astrocytes – Key Players in Human Mesial Temporal Lobe Epilepsy. Epilepsia. 2008;49 Suppl 2:42-52.

Lee T, Poon S, Chang P. Dissimilar neuropsychiatric presentations of two siblings with Juvenile Neuronal Ceroid-Lupofuscinosis. J Neuropsychiatry Clin Neurosci. 2010 Winter 22: 123.

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