Research Scholar, Pathology Department, Duke University, Durham, NC, United States
host-pathogen interactions; cellular trafficking and communication within lymph nodes; mast cells; viral immunology; vaccination
Syenina, A., Jagaraj, C.J., Aman, S.A., Sridharan, A. and St John, A.L. (2015) Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors. eLife. Mar 18;4. http://elifesciences.org/content/4/e05291
St John, A.L.*, Ang, W.X., Huang, M.N., Kunder, C.A., Chan, E.W., Gunn, M.D. and Abraham, S.N. (2014) S1P-dependent trafficking of intracellular yersinia pestis through lymph nodes establishes buboes and systemic infection. Immunity. Sep 18;41(3):440-50.
St John, A.L., Abraham, S.N. and Gubler, D.J. (2013) Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis. Nature Reviews Microbiology 11: 420-426.
St John, A.L.*, Rathore, A.P., Raghavan, B., Ng, M.L. and Abraham, S.N. (2013) Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage. eLife 2: e00481. (*corresponding author) : http://elife.elifesciences.org/content/2/e00481
St John, A.L. and Abraham, S.N. (2013) Innate immunity and its regulation by mast cells. Journal of Immunology 190: 4458-4463. (*corresponding author)
Chan, C.Y., St John, A.L., & Abraham, S.N., (2013). Mast cell interleukin-10 drives localized tolerance in chronic bladder infection. Immunity 38 (2), 349-359.
St John, A.L.*, Chan, C.Y., Staats, H.F., Leong, K.W. & Abraham, S.N. (2012). Synthetic Mast Cell Granules as Adjuvants to Promote and Polarize Immunity in Lymph Nodes. Nature Materials 11 (3), 250-257. (*designates corresponding author) (Featured in “News and Views”)
Kunder, C.A., St John, A.L.* & Abraham, S.N. (2011). Mast cell modulation of the vascular and lymphatic endothelium. Blood. 118 (20), 5383-5393. (*designates corresponding author)
St John, A.L.*, Rathore, A., Yap, H., Metcalfe, D., Ng, M.M., Vasudevan, S. and Abraham, S.N. (2011). Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance. Proceedings of the National Academy of Sciences U S A. 108 (22), 9190-9195 (2011). (*designates corresponding author) http://www.pnas.org/content/108/22/9190.full
Abraham, S.N. and St John, A.L. (2010). Mast cell-orchestrated immunity to pathogens. Nature Reviews Immunology 10(6):440-452.
St John, A.L., and Abraham, S.N. (2009). Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Nature Medicine 15, 1259-1265.
Kunder, C.A.*, St John, A.L.*, Li, G., Leong, K.W., Berwin, B., Staats, H.F., and Abraham, S.N. (2009). Mast cell-derived particles deliver peripheral signals to remote lymph nodes. J Exp Med 206, 2455-2467. (*designates co-first author)
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