Wang Yibin

Visiting Professor

Email

Contact: 66011353

Dr. Wang obtained his training in molecular genetics and cell biology from Baylor College of Medicine, and conducted post-doctoral research in neurobiology and cardiovascular diseases at The Scripps Research Institute and UC, San Diego. Since 1998, Dr. Wang’s laboratory has focused on genetic network and molecular basis of cardiovascular physiology and diseases. Dr. Wang’s lab has a long track record in discovering novel components and novel interactions in stress-signal transduction pathways in mammalian cells through biochemical, proteomic, molecular and genomic approaches. Recently, Wang lab has also employed systems-based approach in gene and pathway discovery for cardiovascular and metabolic disease. Dr. Wang’s lab has established a broad spectrum of research approaches in cardiac biology, from molecular biology, cell physiology to intact heart physiology, genomics and systems biology. Dr. Wang has been supported by NIH, DoD and other extramural grants throughout his research career and published more than 240 scientific articles. Dr. Wang served as the Chair of Cardiovascular Theme at UCLA from 2015 to 2019, a new initiative to build an integrated Cardiovascular Medicine and Research infrastructure at UCLA. D. Wang has four licensed patents and is a scientific founder of a biotech start-up. In addition to being the PI of an 12 people research team, Dr. Wang is also actively engaged in teaching and education, served as the Education Director for UCLA Cardiovascular Research Laboratories and vice Chair of UCLA Molecular, Cellular and Integrated Physiology Ph.D. program. 

Wang laboratory has been focusing on understanding the intracellular signaling networks involved in stress-response in mammalian cells, and translating that knowledge into potential therapies. The research progresses are centered on three related areas of investigations: 1). Discovering novel components in stress signal transduction networks; 2). Establishing functional and molecular links among signaling pathways;  3). Translating mechanistic insights into novel therapies in disease models of heart failure and metabolic disorders. Up to now, Wang’s lab has published over 242 peer-reviewed scientific reports. The total H-index is 82 for all papers and 50 for publication since 2016 based on Google Scholar. The four most significant areas of contribution and several recent publications with significant novelty and potential impact on the field of heart failure research and basic signal transduction are listed below.   These studies illustrate the principal features of our research by taking state-of-the-art experimental tools to explore frontier areas of biology and medicine.

 

Recent Selected Publications: 

Zhang XJ, She ZG, Wang J, Sun D, Shen LJ, Xiang H, Cheng X, Ji YX, Huang YP, Li PL, Yang X, Cheng Y, Ma JP, Wang HP, Hu Y, Hu F, Tian S, Tian H, Zhang P, Zhao GN, Wang L, Hu ML, Yang Q, Zhu LH, Cai J, Yang J, Zhang X, Ma X, Xu Q, Touyz RM, Liu PP, Loomba R, Wang Y, Li H. Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis. Science translational medicine. 2021;13(624):eabg8117. Epub 2021/12/16. doi: 10.1126/scitranslmed.abg8117. PubMed PMID: 34910546.

Zhang XJ, Liu X, Hu M, Zhao GJ, Sun D, Cheng X, Xiang H, Huang YP, Tian RF, Shen LJ, Ma JP, Wang HP, Tian S, Gan S, Xu H, Liao R, Zou T, Ji YX, Zhang P, Cai J, Wang ZV, Meng G, Xu Q, Wang Y, Ma XL, Liu PP, Huang Z, Zhu L, She ZG, Zhang X, Bai L, Yang H, Lu Z, Li H. Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species. Cell metabolism. 2021;33(10):2059-75.e10. Epub 2021/09/19. doi: 10.1016/j.cmet.2021.08.014. PubMed PMID: 34536344.

Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H. A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques. Science translational medicine. 2021;13(624):eabg8116. Epub 2021/12/16. doi: 10.1126/scitranslmed.abg8116. PubMed PMID: 34910548.

Yokota T, Wang Y. Damage control in broken heart-DNA damage response as a common path in arrhythmogenic cardiomyopathy. Cardiovascular research. 2021. Epub 2021/03/12. doi: 10.1093/cvr/cvab064. PubMed PMID: 33693630.

Schiattarella GG, Wang Y, Tian R, Hill JA. Metabolism and Inflammation in Cardiovascular Health and Diseases: Mechanisms to Therapies. Journal of molecular and cellular cardiology. 2021. Epub 2021/03/06. doi: 10.1016/j.yjmcc.2021.02.011. PubMed PMID: 33667418.

Kelly SC, Rau CD, Ouyang A, Thorne PK, Olver TD, Edwards JC, Domeier TL, Padilla J, Grisanti LA, Fleenor BS, Wang Y, Scott Rector R, Emter CA. The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature. Physiol Genomics. 2021;53(3):99-115. Epub 2021/01/26. doi: 10.1152/physiolgenomics.00093.2020. PubMed PMID: 33491589; PMCID: PMC7988741.

Gong X, Tian M, Cao N, Yang P, Xu Z, Zheng S, Liao Q, Chen C, Zeng C, Jose PA, Wang DZ, Jian Z, Xiao Y, Jiang DS, Wei X, Zhang B, Wang Y, Chen K, Wu G, Zeng C. Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. J Clin Invest. 2021;131(24). Epub 2021/12/16. doi: 10.1172/jci147031. PubMed PMID: 34907911.

Gao C, Yu J, Wang Y. Branched chain amino acids in cardiac growth and pathology - timing is everything. Journal of molecular and cellular cardiology. 2021;159:14-5. Epub 2021/06/14. doi: 10.1016/j.yjmcc.2021.05.020. PubMed PMID: 34119505.

Gao C, Cao N, Wang Y. The coming of age for branched-chain amino acids. J Cardiovasc Aging. 2021;1(2). Epub 2021/09/28. doi: 10.20517/jca.2021.02. PubMed PMID: 34568877; PMCID: PMC8459750.

Gao C, Cao N, Wang Y. Metal dependent protein phosphatase PPM family in cardiac health and diseases. Cell Signal. 2021:110061. Epub 2021/06/07. doi: 10.1016/j.cellsig.2021.110061. PubMed PMID: 34091011.

Chapski DJ, Cabaj M, Morselli M, Mason RJ, Soehalim E, Ren S, Pellegrini M, Wang Y, Vondriska TM, Rosa-Garrido M. Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart. Journal of molecular and cellular cardiology. 2021. Epub 2021/07/18. doi: 10.1016/j.yjmcc.2021.07.002. PubMed PMID: 34273410.

Cai J, Li H, Zhang C, Chen Z, Liu H, Lei F, Qin JJ, Liu YM, Zhou F, Song X, Zhou J, Zhao YC, Wu B, He M, Yang H, Zhu L, Zhang P, Ji YX, Zhao GN, Lu Z, Liu L, Mao W, Liao X, Lu H, Wang D, Xia X, Huang X, Wei X, Xia J, Zhang BH, Yuan Y, She ZG, Xu Q, Ma X, Wang Y, Yang J, Zhang X, Zhang XJ, Li H. The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19. Cell metabolism. 2021. Epub 2021/01/10. doi: 10.1016/j.cmet.2021.01.002. PubMed PMID: 33421384.

Baranowski BJ, Allen MD, Nyarko JN, Rector RS, Padilla J, Mousseau DD, Rau CD, Wang Y, Laughlin MH, Emter CA, MacPherson RE, Olver TD. Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure. JCI insight. 2021;6(10). Epub 2021/05/25. doi: 10.1172/jci.insight.143141. PubMed PMID: 34027891.

Zhang XJ, Qin JJ, Cheng X, Shen L, Zhao YC, Yuan Y, Lei F, Chen MM, Yang H, Bai L, Song X, Lin L, Xia M, Zhou F, Zhou J, She ZG, Zhu L, Ma X, Xu Q, Ye P, Chen G, Liu L, Mao W, Yan Y, Xiao B, Lu Z, Peng G, Liu M, Yang J, Yang L, Zhang C, Lu H, Xia X, Wang D, Liao X, Wei X, Zhang BH, Zhang X, Yang J, Zhao GN, Zhang P, Liu PP, Loomba R, Ji YX, Xia J, Wang Y, Cai J, Guo J, Li H. In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19. Cell metabolism. 2020. Epub 2020/06/28. doi: 10.1016/j.cmet.2020.06.015. PubMed PMID: 32592657; PMCID: PMC7311917.

Zhang P, Zhu L, Cai J, Lei F, Qin JJ, Xie J, Liu YM, Zhao YC, Huang X, Lin L, Xia M, Chen MM, Cheng X, Zhang X, Guo D, Peng Y, Ji YX, Chen J, She ZG, Wang Y, Xu Q, Tan R, Wang H, Lin J, Luo P, Fu S, Cai H, Ye P, Xiao B, Mao W, Liu L, Yan Y, Liu M, Chen M, Zhang XJ, Wang X, Touyz RM, Xia J, Zhang BH, Huang X, Yuan Y, Rohit L, Liu PP, Li H. Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19. Circulation research. 2020;126(12):1671-81. Epub 2020/04/18. doi: 10.1161/circresaha.120.317134. PubMed PMID: 32302265; PMCID: PMC7265882.

Yokota T, McCourt J, Ma F, Ren S, Li S, Kim TH, Kurmangaliyev YZ, Nasiri R, Ahadian S, Nguyen T, Tan XHM, Zhou Y, Wu R, Rodriguez A, Cohn W, Wang Y, Whitelegge J, Ryazantsev S, Khademhosseini A, Teitell MA, Chiou PY, Birk DE, Rowat AC, Crosbie RH, Pellegrini M, Seldin M, Lusis AJ, Deb A. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. Cell. 2020. Epub 2020/07/06. doi: 10.1016/j.cell.2020.06.030. PubMed PMID: 32621799.

Yokota T, Li J, Huang J, Xiong Z, Zhang Q, Chan TW, Ding Y, Rau CD, Sung K, Ren S, Kulkarni RP, Hsiai T, Xiao X, Touma M, Minamisawa S, Wang Y. p38 mitogen-activated protein kinase regulates chamber specific perinatal growth in heart. J Clin Invest. 2020. Epub 2020/06/24. doi: 10.1172/JCI135859. PubMed PMID: 32573492.

Wang Y, Foo R, Thum T. Using "old" medications to fight new COVID-19: Re-purposing with a purpose. Journal of molecular and cellular cardiology. 2020. Epub 2020/07/21. doi: 10.1016/j.yjmcc.2020.07.005. PubMed PMID: 32687852.

Rau CD, Lusis AJ, Wang Y. Systems Genetics for Mechanistic Discovery in Heart Diseases. Circulation research. 2020;126(12):1795-815. Epub 2020/06/05. doi: 10.1161/circresaha.119.315863. PubMed PMID: 32496909.

Qin JJ, Cheng X, Zhou F, Lei F, Akolkar G, Cai J, Zhang XJ, Blet A, Xie J, Zhang P, Liu YM, Huang Z, Zhao LP, Lin L, Xia M, Chen MM, Song X, Bai L, Chen Z, Zhang X, Xiang D, Chen J, Xu Q, Ma XL, Touyz RM, Gao C, Wang H, Liu L, Mao W, Luo P, Yan Y, Ye P, Chen M, Chen G, Zhu L, She ZG, Huang X, Yuan Y, Zhang BH, Wang Y, Liu PP, Li H. Redefining cardiac biomarkers in predicting mortality of inpatients with COVID-19. Hypertension (Dallas, Tex : 1979). 2020. Epub 2020/07/17. doi: 10.1161/hypertensionaha.120.15528. PubMed PMID: 32673499.

Luczak ED, Wu Y, Granger JM, Joiner MA, Wilson NR, Gupta A, Umapathi P, Murphy KR, Reyes Gaido OE, Sabet A, Corradini E, Tseng WW, Wang Y, Heck AJR, Wei AC, Weiss RG, Anderson ME. Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy. Nature communications. 2020;11(1):4416. Epub 2020/09/06. doi: 10.1038/s41467-020-18165-6. PubMed PMID: 32887881; PMCID: PMC7473864.

Lu D, Chatterjee S, Xiao K, Riedel I, Wang Y, Foo R, Bär C, Thum T. MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes. Journal of molecular and cellular cardiology. 2020;148:46-9. Epub 2020/09/07. doi: 10.1016/j.yjmcc.2020.08.017. PubMed PMID: 32891636; PMCID: PMC7470794.

Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H. Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis. Cell metabolism. 2020;31(5):892-908.e11. Epub 2020/05/07. doi: 10.1016/j.cmet.2020.04.011. PubMed PMID: 32375062.

Gao C, Wang Y. mRNA Metabolism in Cardiac Development and Disease: Life After Transcription. Physiol Rev. 2020;100(2):673-94. Epub 2019/11/22. doi: 10.1152/physrev.00007.2019. PubMed PMID: 31751167.

Foo R, Wang Y, Zimmermann WH, Backs J, Wang DW. Cardiovascular molecular mechanisms of disease with COVID-19. Journal of molecular and cellular cardiology. 2020;141:107. Epub 2020/04/15. doi: 10.1016/j.yjmcc.2020.04.010. PubMed PMID: 32289321; PMCID: PMC7151487.

Cheng X, Liu YM, Li H, Zhang X, Lei F, Qin JJ, Chen Z, Deng KQ, Lin L, Chen MM, Song X, Xia M, Huang X, Liu W, Cai J, Zhang XJ, Zhou F, Zhang P, Wang Y, Ma X, Xu Q, Yang J, Ye P, Mao W, Huang X, Xia J, Zhang BH, Guo J, Zhu L, Lu Z, Yuan Y, Wei X, She ZG, Ji YX, Li H. Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes. Cell metabolism. 2020. Epub 2020/08/31. doi: 10.1016/j.cmet.2020.08.013. PubMed PMID: 32861268.

Cannata F, Chiarito M, Reimers B, Azzolini E, Ferrante G, My I, Viggiani G, Panico C, Regazzoli D, Ciccarelli M, Voza A, Aghemo A, Li H, Wang Y, Condorelli G, Stefanini GG. Continuation versus discontinuation of ACE inhibitors or angiotensin II receptor blockers in COVID-19: effects on blood pressure control and mortality. Eur Heart J Cardiovasc Pharmacother. 2020. Epub 2020/06/06. doi: 10.1093/ehjcvp/pvaa056. PubMed PMID: 32501480; PMCID: PMC7314058.

Bozadjieva Kramer N, Evers SS, Shin JH, Silverwood S, Wang Y, Burant CF, Sandoval DA, Seeley RJ. The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation. Cell reports. 2020;33(2):108239. Epub 2020/10/15. doi: 10.1016/j.celrep.2020.108239. PubMed PMID: 33053352.

Zhou M, Shao J, Wu CY, Shu L, Dong W, Liu Y, Chen M, Wynn RM, Wang J, Wang J, Gui WJ, Qi X, Lusis AJ, Li Z, Wang W, Ning G, Yang X, Chuang DT, Wang Y, Sun H. Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance. Diabetes. 2019;68(9):1730-46. Epub 2019/06/07. doi: 10.2337/db18-0927. PubMed PMID: 31167878; PMCID: PMC6702639.

Yu J, Zeng C, Wang Y. Epigenetics in dilated cardiomyopathy. Current opinion in cardiology. 2019;34(3):260-9. Epub 2019/04/12. doi: 10.1097/HCO.0000000000000616. PubMed PMID: 30973397; PMCID: PMC6581652.

Woo SL, Yang J, Hsu M, Yang A, Zhang L, Lee RP, Gilbuena I, Thames G, Huang J, Rasmussen A, Carpenter CL, Henning SM, Heber D, Wang Y, Li Z. Effects of branched-chain amino acids on glucose metabolism in obese, prediabetic men and women: a randomized, crossover study. The American journal of clinical nutrition. 2019;109(6):1569-77. Epub 2019/04/22. doi: 10.1093/ajcn/nqz024. PubMed PMID: 31005973; PMCID: PMC6900494.

Wang J, Liu Y, Lian K, Shentu X, Fang J, Shao J, Chen M, Wang Y, Zhou M, Sun H. BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice. Frontiers in physiology. 2019;10:1140. Epub 2019/09/26. doi: 10.3389/fphys.2019.01140. PubMed PMID: 31551816; PMCID: PMC6738029.

Wang J, Huertas-Vazquez A, Wang Y, Lusis AJ. Isoproterenol-Induced Cardiac Diastolic Dysfunction in Mice: A Systems Genetics Analysis. Frontiers in cardiovascular medicine. 2019;6:100. Epub 2019/08/17. doi: 10.3389/fcvm.2019.00100. PubMed PMID: 31417910; PMCID: PMC6684968.

Tzimas C, Rau CD, Buergisser PE, Jean-Louis G, Jr., Lee K, Chukwuneke J, Dun W, Wang Y, Tsai EJ. WIPI1 is a conserved mediator of right ventricular failure. JCI insight. 2019;5. Epub 2019/04/26. doi: 10.1172/jci.insight.122929. PubMed PMID: 31021818; PMCID: PMC6629151.

Sun H, Wang Y. A new branch connecting thermogenesis and diabetes. Nature Metabolism. 2019;1(9):845-6. doi: 10.1038/s42255-019-0112-1.

Olver TD, Edwards JC, Jurrissen TJ, Veteto AB, Jones JL, Gao C, Rau C, Warren CM, Klutho PJ, Alex L, Ferreira-Nichols SC, Ivey JR, Thorne PK, McDonald KS, Krenz M, Baines CP, Solaro RJ, Wang Y, Ford DA, Domeier TL, Padilla J, Rector RS, Emter CA. Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. JACC Basic to translational science. 2019;4(3):404-21. Epub 2019/07/18. doi: 10.1016/j.jacbts.2019.02.004. PubMed PMID: 31312763; PMCID: PMC6610000.

Hu J, Gao C, Wei C, Xue Y, Shao C, Hao Y, Gou LT, Zhou Y, Zhang J, Ren S, Chen J, Wang Y, Fu XD. RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(13):6172-80. Epub 2019/03/15. doi: 10.1073/pnas.1822176116. PubMed PMID: 30867288; PMCID: PMC6442575.

Gao C, Ren SV, Yu J, Baal U, Thai D, Lu J, Zeng C, Yan H, Wang Y. Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure. JACC Basic to translational science. 2019;4(2):161-72. Epub 2019/05/08. doi: 10.1016/j.jacbts.2018.11.001. PubMed PMID: 31061918; PMCID: PMC6488764.

Chen M, Gao C, Yu J, Ren S, Wang M, Wynn RM, Chuang DT, Wang Y, Sun H. Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure. Journal of the American Heart Association. 2019;8(11):e011625. Epub 2019/08/23. doi: 10.1161/JAHA.118.011625. PubMed PMID: 31433721; PMCID: PMC6585363.

Steiger D, Yokota T, Li J, Ren S, Minamisawa S, Wang Y. The serine/threonine-protein kinase/endoribonuclease IRE1alpha protects the heart against pressure overload-induced heart failure. The Journal of biological chemistry. 2018;293(25):9652-61. Epub 2018/05/18. doi: 10.1074/jbc.RA118.003448. PubMed PMID: 29769316; PMCID: PMC6016466.

Park S, Ranjbarvaziri S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vazquez A, Wu X, Qiao R, Soffer JM, Rau C, Wang Y, Mikkola HKA, Lusis AJ, Ardehali R. Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. Circulation. 2018;138(12):1224-35. Epub 2018/06/29. doi: 10.1161/CIRCULATIONAHA.118.035420. PubMed PMID: 29950403; PMCID: PMC6202226.

McKinsey TA, Vondriska TM, Wang Y. Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. F1000Research. 2018;7. Epub 2018/11/13. doi: 10.12688/f1000research.15797.1. PubMed PMID: 30416708; PMCID: PMC6206605.

Touma M, Reemtsen B, Halnon N, Alejos J, Finn JP, Nelson SF, Wang Y. A Path to Implement Precision Child Health Cardiovascular Medicine. Frontiers in cardiovascular medicine. 2017;4:36. Epub 2017/06/18. doi: 10.3389/fcvm.2017.00036. PubMed PMID: 28620608; PMCID: PMC5451507.

Touma M, Kang X, Gao F, Zhao Y, Cass AA, Biniwale R, Xiao X, Eghbali M, Coppola G, Reemtsen B, Wang Y. Wnt11 regulates cardiac chamber development and disease during perinatal maturation. JCI insight. 2017;2(17). Epub 2017/09/08. doi: 10.1172/jci.insight.94904. PubMed PMID: 28878122; PMCID: PMC5621892.

Shimizu H, Langenbacher AD, Huang J, Wang K, Otto G, Geisler R, Wang Y, Chen JN. The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. eLife. 2017;6. Epub 2017/08/23. doi: 10.7554/eLife.27955. PubMed PMID: 28826496; PMCID: PMC5576919.

Rose BA, Yokota T, Chintalgattu V, Ren S, Iruela-Arispe L, Khakoo AY, Minamisawa S, Wang Y. Cardiac myocyte p38alpha kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart. The Journal of biological chemistry. 2017;292(31):12787-800. Epub 2017/06/24. doi: 10.1074/jbc.M117.784553. PubMed PMID: 28637870; PMCID: PMC5546022.

Rosa-Garrido M, Chapski DJ, Schmitt AD, Kimball TH, Karbassi E, Monte E, Balderas E, Pellegrini M, Shih TT, Soehalim E, Liem D, Ping P, Galjart NJ, Ren S, Wang Y, Ren B, Vondriska TM. High-Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure. Circulation. 2017;136(17):1613-25. Epub 2017/08/13. doi: 10.1161/CIRCULATIONAHA.117.029430. PubMed PMID: 28802249; PMCID: PMC5648689.

Rau CD, Romay MC, Tuteryan M, Wang JJ, Santolini M, Ren S, Karma A, Weiss JN, Wang Y, Lusis AJ. Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. Cell systems. 2017;4(1):121-8 e4. Epub 2016/11/22. doi: 10.1016/j.cels.2016.10.016. PubMed PMID: 27866946; PMCID: PMC5338604.

Pillai ICL, Li S, Romay M, Lam L, Lu Y, Huang J, Dillard N, Zemanova M, Rubbi L, Wang Y, Lee J, Xia M, Liang O, Xie YH, Pellegrini M, Lusis AJ, Deb A. Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification. Cell Stem Cell. 2017;20(2):218-32 e5. Epub 2016/11/22. doi: 10.1016/j.stem.2016.10.005. PubMed PMID: 27867037; PMCID: PMC5291784.

Gao C, Wang Y. Untangle a Broken Heart via Janus Kinase 1. Circulation research. 2017;121(6):589-90. Epub 2017/09/02. doi: 10.1161/CIRCRESAHA.117.311684. PubMed PMID: 28860312; PMCID: PMC5599179.

Akaike T, Du N, Lu G, Minamisawa S, Wang Y, Ruan H. A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart. JACC Basic to translational science. 2017;2(2):160-80. Epub 2017/10/24. doi: 10.1016/j.jacbts.2016.12.002. PubMed PMID: 29057374; PMCID: PMC5648354.

Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nature medicine. 2016;22(10):1131-9. Epub 2016/09/13. doi: 10.1038/nm.4179. PubMed PMID: 27618650; PMCID: PMC5053883.

Wang JJ, Rau C, Avetisyan R, Ren S, Romay MC, Stolin G, Gong KW, Wang Y, Lusis AJ. Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. PLoS genetics. 2016;12(7):e1006038. Epub 2016/07/08. doi: 10.1371/journal.pgen.1006038. PubMed PMID: 27385019; PMCID: PMC4934852.

Wang JJ, Aboulhosn JA, Hofer IS, Mahajan A, Wang Y, Vondriska TM. Operationalizing Precision Cardiovascular Medicine: Three Innovations. Circulation research. 2016;119(9):984-7. Epub 2016/10/16. doi: 10.1161/CIRCRESAHA.116.309776. PubMed PMID: 27737942; PMCID: PMC5135087.

Touma M, Kang X, Zhao Y, Cass AA, Gao F, Biniwale R, Coppola G, Xiao X, Reemtsen B, Wang Y. Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery. Circulation Cardiovascular genetics. 2016;9(5):395-407. Epub 2016/10/21. doi: 10.1161/CIRCGENETICS.115.001363. PubMed PMID: 27591185; PMCID: PMC5085833.

Sun H, Wang Y. Branched chain amino acid metabolic reprogramming in heart failure. Biochimica et biophysica acta. 2016;1862(12):2270-5. Epub 2016/09/19. doi: 10.1016/j.bbadis.2016.09.009. PubMed PMID: 27639835.

Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation. 2016;133(21):2038-49. Epub 2016/04/10. doi: 10.1161/CIRCULATIONAHA.115.020226. PubMed PMID: 27059949; PMCID: PMC4879058.

Rau CD, Gao C, Wang Y. Deconvolution of the Human Endothelial Transcriptome. Cell systems. 2016;3(3):218-20. Epub 2016/09/30. doi: 10.1016/j.cels.2016.09.006. PubMed PMID: 27684186; PMCID: PMC5394198.

Iorga A, Li J, Sharma S, Umar S, Bopassa JC, Nadadur RD, Centala A, Ren S, Saito T, Toro L, Wang Y, Stefani E, Eghbali M. Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. Journal of the American Heart Association. 2016;5(1). Epub 2016/01/24. doi: 10.1161/JAHA.115.002482. PubMed PMID: 26802104; PMCID: PMC4859364.

Gao C, Wang Y. Positive Role for a Negative Calcineurin Regulator in Cardiac Hypertrophy. Hypertension (Dallas, Tex : 1979). 2016;67(5):841-2. Epub 2016/03/30. doi: 10.1161/HYPERTENSIONAHA.116.07140. PubMed PMID: 27021013; PMCID: PMC4862578.

Gao C, Ren S, Lee JH, Qiu J, Chapski DJ, Rau CD, Zhou Y, Abdellatif M, Nakano A, Vondriska TM, Xiao X, Fu XD, Chen JN, Wang Y. RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. J Clin Invest. 2016;126(1):195-206. Epub 2015/12/01. doi: 10.1172/JCI84015. PubMed PMID: 26619120; PMCID: PMC4701548.

Wang Z, Wang Y. Dawn of the Epi-LncRNAs: new path from Myheart. Circulation research. 2015;116(2):235-6. Epub 2015/01/17. doi: 10.1161/CIRCRESAHA.114.305490. PubMed PMID: 25593274; PMCID: PMC4313530.

Sun H, Wang Y. The elusive philosopher's stone in young blood. Circulation research. 2015;117(11):906-8. Epub 2015/11/07. doi: 10.1161/CIRCRESAHA.115.307645. PubMed PMID: 26541677; PMCID: PMC4638134.

Sun H, Gao C, Wang Y. A H(a)rd Way to Adapt in Cardiac Hypertrophy. Circulation research. 2015;117(6):484-6. Epub 2015/09/01. doi: 10.1161/CIRCRESAHA.115.307164. PubMed PMID: 26316602; PMCID: PMC4582434.

Rau CD, Wang J, Avetisyan R, Romay MC, Martin L, Ren S, Wang Y, Lusis AJ. Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice. Circulation Cardiovascular genetics. 2015;8(1):40-9. Epub 2014/12/07. doi: 10.1161/CIRCGENETICS.113.000732. PubMed PMID: 25480693; PMCID: PMC4334708.

Deb A, Wang Y. Hypertrophic preconditioning: short-term tricks for long-term gain. Circulation. 2015;131(17):1468-70. Epub 2015/03/31. doi: 10.1161/CIRCULATIONAHA.115.016330. PubMed PMID: 25820337; PMCID: PMC4539559.

Xiao XG, Touma M, Wang Y. Decoding the noncoding transcripts in human heart failure. Circulation. 2014;129(9):958-60. Epub 2014/01/17. doi: 10.1161/CIRCULATIONAHA.114.007548. PubMed PMID: 24429689; PMCID: PMC4046328.

Sun H, Wang Y. Interferon regulatory factors in heart: stress response beyond inflammation. Hypertension (Dallas, Tex : 1979). 2014;63(4):663-4. Epub 2014/01/08. doi: 10.1161/HYPERTENSIONAHA.113.02795. PubMed PMID: 24396026; PMCID: PMC4046326.

Lam MP, Wang D, Lau E, Liem DA, Kim AK, Ng DC, Liang X, Bleakley BJ, Liu C, Tabaraki JD, Cadeiras M, Wang Y, Deng MC, Ping P. Protein kinetic signatures of the remodeling heart following isoproterenol stimulation. J Clin Invest. 2014;124(4):1734-44. Epub 2014/03/13. doi: 10.1172/JCI73787. PubMed PMID: 24614109; PMCID: PMC3973111.

Gao C, Wang Y. Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome. Circ J. 2014;78(5):1038-47. Epub 2014/04/25. doi: 10.1253/circj.cj-14-0412. PubMed PMID: 24759793; PMCID: PMC4306672.