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Chia Shi Lu

Associate Professor


Education Qualifications: MBBS, DFDC (CAW), FRCS (Surg), FRCS (Ortho & Trauma), DIC, PhD

Dr Chia has been with the Department since 2001. He is trained and has worked in Switzerland, Japan, London (UK) and Boston (USA). His current research interests include arthritis, cartilage biology, cartilage tissue engineering and artificial joint design. Apart from his clinical appointments, he teaches at both the Duke-NUS Medical School and the NUS Yong Loo Lin School of Medicine.

Dr Chia’s sub-specialty clinical interests include:
Knee and Hip Surgery, including cartilage regeneration and joint preservation techniques
Joint Replacement and Arthritis Surgery
Minimally-invasive joint surgery; computer-navigated surgery

Aside from his clinical interests in lower limb arthroplasty and cartilage repair, he remains committed to both research and teaching, and holds various academic and research appointments.  Dr Chia is frequently invited to deliver lectures and conduct courses both locally and internationally. He also holds various administrative appointments within the hospital and at the national level in conjunction with the Ministry of Health. His teaching commitments locally extend to NUS, NTU, Singapore Polytechnic.  He is also a member of the Curriculum Advisory Board of the Bioengineering Program of UniSIM.


Professional Appointments and Committee Memberships:  

  • Member of Parliament, Tanjong Pagar GRC
  • Chairman, Government Parliamentary Committee for Health
  • Member, Government Parliamentary Committee for the Environment 
  • Member, Singapore Orthopaedic Association
  • Fellow, Academy of Medicine Singapore
  • Vice Chairman, Tanjong Pagar Town Council


  • Service Quality Award, Singapore General Hospital (2008-2012)
  • NIRA Investigator Award, USA (2008)
  • Orthopaedic Excellence Teaching Award, NUS (2006, 2007)

Leadership positions / roles in Education: 

  • Associate Director, Normal Body Program, Duke-NUS Medical School

Research Interests: 

  • Cartilage biology and regeneration, soft tissue engineering
  • Joint replacement and cartilage/soft tissue repair surgery
  • Joint preservation techniques
  • Minimally-invasive joint surgery
  • Computer-navigated surgery
  • Data analytics for disease and surgery outcomes
  • Joint implant design

Selected Publications:

Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system
Inglis, JJ; McNamee, KE; Chia, SL; Essex, D; Feldmann, M; Williams, RO; Hunt, SP; Vincent, T
Arthritis Rheum., 2008 vol. 58(10) pp. 3110-9

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis
Chia, SL; Sawaji, Y; Burleigh, A; McLean, C; Inglis, J; Saklatvala, J; Vincent, T
Arthritis Rheum., 2009 vol. 60(7) pp. 2019-27

Liow Ming Han Lincoln; Goh Graham Seow-Hng; Tay Darren Keng-Jin; Chia Shi-Lu; Lo Ngai-Nung; Yeo Seng-Jin
Obesity and the absence of trochlear dysplasia increase the risk of revision in patellofemoral arthroplasty.
The Knee 2016; 23(2):331-7

Zhu Meng; Ang Chia Liang; Yeo Seng Jin; Lo Ngai Nung; Chia Shi-Lu; Chong Hwei Chi
Minimally Invasive Computer-Assisted Total Knee Arthroplasty Compared With Conventional Total Knee Arthroplasty: A Prospective 9-Year Follow-Up.
The Journal of arthroplasty 2016; 31(5):1000-4

Chen Jerry Yongqiang; Chin Pak Lin; Moo Ing How; Pang Hee Nee; Tay Darren Keng Jin;Chia Shi-Lu; Lo Ngai Nung; Yeo Seng Jin
Intravenous versus intra-articular tranexamic acid in total knee arthroplasty: A double-blinded randomised controlled noninferiority trial.
The Knee 2016; 23(1):152-6

Chen Jerry Yongqiang; Loh Bryan; Woo Yew Lok;Chia Shi-Lu; Lo Ngai Nung; Yeo Seng Jin
Fixed Flexion Deformity After Unicompartmental Knee Arthroplasty: How Much Is Too Much.
The Journal of arthroplasty 2016; 31(6):1313-6

Jiang Lei; Chen Jerry Yongqiang; Chong Hwei-Chi; Chia Shi-Lu; Lo Ngai-Nung; Yeo Seng Jin
Early Outcomes of Unicompartmental Knee Arthroplasty in Patients With Preoperative Genu Recurvatum of Non-neurological Origin.
The Journal of arthroplasty 2016; 31(6):1204-7

Bin Abd Razak Hamid Rahmatullah; Tan Chuen-Seng; Chen Yongqiang Jerry Delphi; Pang Hee-Nee; Tay Keng-Jin Darren; Chin Pak-Lin; Chia Shi-Lu; Lo Ngai-Nung; Yeo Seng-Jin
Age and Preoperative Knee Society Score Are Significant Predictors of Outcomes Among Asians Following Total Knee Arthroplasty.
The Journal of bone and joint surgery. American volume 2016; 98(9):735-41 (Article; Published in Print). IF = 5.163

Chen J Y; Lo N N; Chong H C; Bin Abd Razak H R; Pang H N; Tay D K J; Chia S L; Yeo S J
The influence of body mass index on functional outcome and quality of life after total knee arthroplasty.
The bone & joint journal 2016; 98-B(6):780-5 

Yeh Jared Ze Yang; Chen Jerry Yongqiang; Bin Abd Razak Hamid Rahmatullah; Loh Bryan Huai Gu; Hao Ying; Yew Andy Khye Soon; Chia Shi-Lu; Lo Ngai Nung; Yeo Seng Jin
Preoperative haemoglobin cut-off values for the prediction of post-operative transfusion in total knee arthroplasty.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 2016; 24(10):3293-3298

Koo Kevin; Silva Amila; Chong Hwei Chi; Chin Pak Lin; Chia Shi Lu; Lo Ngai Ngung; Yeo Seng Jin
Genu Recurvatum versus Fixed Flexion after Total Knee Arthroplasty.
Clinics in orthopedic surgery 2016; 8(3):249-53

Seng C S; Ho Derek C; Chong H C; Chia S L; Chin P L; Lo N N; Yeo S J
Outcomes and survivorship of unicondylar knee arthroplasty in patients with severe deformity.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 2017; 25(3):639-644

Zhu Meng; Chen Jerry Yongqiang; Chong Hwei Chi; Yew Andy Khye Soon; Foo Leon Siang Shen; Chia Shi-Lu; Lo Ngai Nung; Yeo Seng Jin
Outcomes following total knee arthroplasty with CT-based patient-specific instrumentation.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 2017; 25(8):2567-2572

Yeh Jared Ze Yang; Chen Jerry Yongqiang; Lee Wu Chean; Chong Hwei Chi; Pang Hee Nee; Tay Darren Keng Jin; Chia Shi-Lu; Lo Ngai Nung; Yeo Seng Jin
Identifying an Ideal Time Frame for Staged Bilateral Total Knee Arthroplasty to Maximize Functional Outcome.
The journal of knee surgery 2017; 30(7):682-686

Loh Bryan; Chen Jerry Yongqiang; Yew Andy Khye Soon; Pang Hee Nee; Tay Darren Keng Jin; Chia Shi-Lu; Lo Ngai Nung; Yeo Seng Jin
The accuracy of a hand-held navigation system in total knee arthroplasty.
Archives of orthopaedic and trauma surgery 2017; 137(3):381-386

Ang B F H; Chen J Y; Yew A K S; Chua S K; Chou S M; Chia S L; Koh J S B; Howe T S
Externalised locking compression plate as an alternative to the unilateral external fixator: a biomechanical comparative study of axial and torsional stiffness.
Bone & joint research 2017; 6(4):216-223

Lim J B T; Chong H C; Pang H N; Tay K J D; Chia S L; Lo N N; Yeo S J
Revision total knee arthroplasty for failed high tibial osteotomy and unicompartmental knee arthroplasty have similar patient-reported outcome measures in a two-year follow-up study.
The bone & joint journal 2017; 99-B(10):1329-1334