“Nipah virus matrix protein: expert hacker of cellular machines”

Start Date & Time: 
Tuesday, 25 July, 2017 - 16:00
End Date & Time: 
Tuesday, 25 July, 2017 - 17:00
Venue: 

Meeting Room 5C
Level 5
Duke-NUS Medical School
8 College Road
Singapore 169857

Speaker: 
Speaker Details: 

Benhur Lee, M.D. (AΩA)
Professor
Ward-Coleman Professor of Microbiology, 
Icahn School of Medicine, Mount Sinai, New York City

Synopsis: 

Nipah virus (NiV, Henipavirus) is a highly lethal emergent zoonotic paramyxovirus responsible for outbreaks of encephalitis in South East Asia. Improved understanding of NiV biology is imperative for therapeutic development. NiV matrix protein recruits a plethora of cellular machinery to scaffold and coordinate virion budding, including hijacking cellular trafficking and ubiquitination pathways to facilitate transient nuclear localization. Matrix protein appropriation or subversion of cellular machinery will be discussed in terms of its structural and non-structural roles in the virus life cycle.

Biography: 

Benhur Lee graduated from Yale University School of Medicine (1995) with an M.D. (AΩA), and did his clinical and post-doctoral training at the University of Pennsylvania (1995-2001) where he also served as Chief Resident (1997). He joined the Department of Microbiology, Immunology & Molecular Genetics at University of California, Los Angeles (David Geffen School of Medicine) in 2001 as an Assistant Professor, and was promoted to Associate Professor in 2007, and to full Professor in 2011. He was recruited to Mount Sinai in 2014.  

Dr. Lee has a special interest in emerging paramyxoviruses, with a focus on molecular viral-host interactions at the level of virus entry and budding mechanisms. Dr. Lee has published over 140 peer-reviewed publications (h index=47), and sits on multiple editorial boards. He is a member of the NIH recombinant DNA Advisory Committee (RAC), and the ICTV Paramyxovirus study group. He has trained more than a dozen post-doctoral fellows, 16 graduate students, and has served on more than 60 PhD dissertation committees between UCLA and Mount Sinai.

Host: 

Professor Linfa Wang
Programme Director
Programme in Emerging Infectious Diseases

Contact Person: 

Ms Shirley William
shirleywilliam@duke-nus.edu.sg