Diabetes and Cardiovascular Disease in South Asians: Insights from Population Studies

Start Date & Time: 
Tuesday, 30 May, 2017 - 12:00
End Date & Time: 
Tuesday, 30 May, 2017 - 13:00

Duke-NUS Medical School

Amphitheatre, Level 2

Speaker Details: 

Prof John Chamber

Professor of Cardiovascular Epidemiology

Lee Kong Chian School of Medicine, Singapore

Professor of Cardiovascular Epidemiology

Imperial College London, UK



Prof Chambers’s research focuses on identifying the mechanisms underlying the high rates of diabetes and cardiovascular disease amongst South Asians, and developing new strategies for prediction and prevention of these major diseases. His recent studies have led to discovery of genetic and epigenetic variation associated with coronary heart disease (CHD), type-2 diabetes (T2D), obesity, and related metabolic disturbances, implicating new molecular pathways underlying these complex diseases. His findings underpin ongoing interventional studies, funded by the European Union, to evaluate new strategies for sustainable and cost-effective risk stratification and personalised medicine to prevent obesity and T2D in this high risk population using readily available tools. In the future, his translational research will build on the discovery of numerous novel molecular markers that predict CHD and T2D. Immediate goals include evaluating the potential clinical utility of DNA methylation and other serum molecular markers to identify metabolically unhealthy obesity, and to guide therapeutic intervention for prevention of T2D, thereby taking advantage of the exciting emerging discoveries arising from molecular epidemiology.



Prof Chamber is a Professor of Cardiovascular Epidemiology at Lee Kong Chian School of Medicine, and at Imperial College London, and is a Director of the NIHR Global Health Research Unit for Diabetes and Cardiovascular Disease. He uses population-based approaches to investigate on the mechanisms underlying the obesity, diabetes and cardiovascular disease amongst Asian populations, with a particular focus on DNA sequence variation, molecular regulatory disturbances and their interaction. He leads large-scale prospective, observational population studies in Singapore, South Asia and the UK, as well as interventional studies aimed at prevention of obesity and metabolic disease in high risk individuals. He also intermittently practice as a Consultant Cardiologist.



Prof Patrick Casey

Senior Vice Dean of Research

Duke-NUS Medical School


Contact Person: 

Ms Kathleen Chan, Duke-NUS Research Affairs