The emerging role of the unfolded protein response in lipid disequilibrium and metabolic diseases

Start Date & Time: 
Friday, 24 November, 2017 - 14:00
End Date & Time: 
Friday, 24 November, 2017 - 15:00
Venue: 

Meeting room 7C
Level 7

Speaker: 
Speaker Details: 

Dr Guillaume Thibault
Nanyang Assistant Professor
School of Biological Sciences and
Lee Kong Chian School of Medicine
Nanyang Technological University

 

Synopsis: 

One facet of metabolic disorders is attributed to the perturbation of ER homeostasis through changes in membrane phospholipid, activating the unfolded protein response (UPR). Most studies focus on proteotoxic-induced UPR but few on lipid perturbation (LP)-mediated ER stress. We currently focus to better understand the cell stress responses leading to adaptation or death from LP-induced stress and what cause a cell to go one way or the other using yeast and C. elegans.

Host: 

Assoc Prof Shawn Je
Principal Investigator
Neuroscience & Behavioural Disorders Programme