IIB or not IIB: how does antibody betray us for dengue?

Start Date & Time: 
Tuesday, 2 April, 2013 - 12:00
End Date & Time: 
Tuesday, 2 April, 2013 - 13:00
Venue: 

Duke-NUS Graduate Medical School
Amphitheatre, Level 2

Speaker: 
Speaker Details: 

Assoc Prof Ooi Eng Eong
Program Deputy Director, Emerging Infectious Diseases Program, Duke-NUS Graduate Medical School

Synopsis: 

Antibodies against dengue virus (DENV) can either protect against or enhance infection although the mechanistic determinants of these outcome remain ill understood. We have shown recently that besides blocking virus-receptor interaction, antibodies can also aggregate DENV to form immune complex that co-ligate the inhibitory Fc gamma receptor IIB (FcγRIIB).  This finding raises the possibility of differentiating between long-lived serotype-specific immunity from short-lived cross reactive protection but raises new questions on the mechanism of antibody-enhanced dengue.

Biography: 

Ooi Eng Eong is an Associate Professor and Deputy Director of the Program in Emerging Infectious Diseases here in Duke-NUS Graduate Medical School. Besides the occasional curiosity for quotes from Shakespeare, dengue is his main research interest with particular focus on pathogenesis and immunity.

Host: 

Prof Wang Linfa
Program Director, Emerging Infectious Diseases Program, Duke-NUS Graduate Medical School

Other Information: 

Registration is not required. Light refreshments will be served at 11.30 AM.

Contact Person: 

Ms Jacqueline Goh, Duke-NUS Research Affairs Department
Tel: 6601 2275 or Email: jacqueline.goh@duke-nus.edu.sg