The mammalian target of rapamycin complex 1 (mTORC1) regulates anabolic metabolism

Start Date & Time: 
Wednesday, 3 April, 2013 - 10:30
End Date & Time: 
Wednesday, 3 April, 2013 - 11:30

Duke-NUS Graduate Medical School, Amphitheatre, Level 2

Speaker Details: 

Dr. Chris G Proud
Professor of Cellular Regulation, Centre for Biological Sciences,
University of Southampton


The mammalian target of rapamycin complex 1 (mTORC1) is a tightly-regulated protein kinase that regulates many biosynthetic processes, including protein synthesis and ribosome biogenesis. In particular, mTORC1 regulates the translation of specific mRNAs and the transcription and processing of ribosomal RNA. mTORC1 controls the rate of translation elongation via eukaryotic elongation factor 2 kinase, a very unusual enzyme that plays key roles, e.g., in learning and memory and in cell survival.


Dr. Chris G Proud has a long-standing interest in the signaling mechanisms and protein kinases that regulate mammalian cell function. This interest began when he was a graduate student in Philip Cohen's lab, in Dundee, Scotland, where many years later he served as Head of Molecular Physiology. He was also head of the Department of Biochemistry at the University of British Columbia before returning to the UK in 2008. He now leads a thriving team studying the regulation of protein synthesis and other anabolic processes. 


Prof Shirish Shenolikar
Senior Associate Dean, Office of Research,
Cardiovascular and Metabolic Disorders Program
Duke-NUS Graduate Medical School