NBD Invited Speaker Seminar: Brain connectivity and cognition: The case of the salience network

Start Date & Time: 
Tuesday, 28 February, 2017 - 16:00
End Date & Time: 
Tuesday, 28 February, 2017 - 17:00

Meeting room 7C, Level 7

Speaker Details: 

Lucina Q. Uddin, Ph.D.
Assistant Professor
Department of Psychology
University of Miami



Brain structural and functional development underlies the maturation of increasingly sophisticated cognitive abilities. High-level attentional and cognitive control processes rely on the integrity of, and dynamic interactions between, several core neurocognitive networks. The right insular cortex is a critical component of a salience network (SN) that is thought to mediate interactions between large-scale brain networks involved in externally oriented attention (central executive network, CEN)) and internally oriented cognition (default mode network, DMN)). How these systems reconfigure with development is a critical question for cognitive neuroscience, with implications for neurodevelopmental pathologies affecting brain connectivity. I will describe studies examining interactions within and between the SN, CEN, and DMN in typical and atypical development. Additionally, I will present evidence suggesting a unique role for the dorsal anterior insular from studies of meta-analytic connectivity modeling, dynamic functional connectivity, multivariate pattern analyses. These findings from adults, typically developing children, and children with autism suggest that structural and functional maturation of insular pathways is a critical component of the process by which human brain networks mature to support complex, flexible cognitive processes in adulthood.


Asst Prof Helen Zhou
Principal Investigator