Nuclear architecture, neural identity, and brain aging

Start Date & Time: 
Wednesday, 14 March, 2018 - 12:00
End Date & Time: 
Wednesday, 14 March, 2018 - 13:00
Venue: 

Meeting Room 7C,
Level 7

Speaker: 
Speaker Details: 

Dr Tomohisa Toda
Research Associate
Laboratory of Genetics-Gage
The Salk Institute for Biological Studies
California, USA

Synopsis: 

Individual neural cell types exhibit a distinct nuclear architecture. However, it is still largely unknown how nuclear architectures underlie cell type-specific gene regulation. We recently discovered that the nucleoporin Nup153, one of nuclear pore complex proteins, interacts with Sox2, a key transcription factor, to maintain neural stem cells. This result highlighted that nucleoporin-directed nuclear architecture functions as a structural gatekeeper to maintain neural identity.

Host: 

Prof Zhang Su-Chun
Programme Director
NBD

Other Information: 

Pizza will be served