A Research Blog

Touted as the most common cause of liver failure worldwide, non-alcoholic steatohepatitis (NASH) manifests as inflammation and increased lipotoxicity in liver cells. Accumulation of fat in the liver has been cited as the cause of NASH. Specifically, the accumulation of saturated fatty acids, such as palmitic acid, in liver cells triggers inflammation, and results in oxidative stress and tissue damage. However, not everyone with fat accumulation in the liver develops NASH. Why is that?

Group photo

Pictured, from left to right: Dr. Jin Zhou, Prof Paul Yen and Asst Prof Rohit Sinha


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