A Research Blog

Human GADD34 (Image credit Phosphositeplus, www.phosphosite.org)

Image credit: PhosphoSitePlus®, www.phosphosite.org

Name: GADD34-containing eukaryotic initiation factor 2α phosphatase (GADD34)

Action: Dephosphorylates eukaryotic initiation factor 2α (eIF2α), thereby reducing the translation of endoplasmic reticulum (ER)-targeted proteins

Gene: Ppp1r15a

What was known before:

GADD34 was thought to only be expressed as a response to cellular stress, where its main function is to reverse eIF2α phosphorylation and promote the translation of stress response proteins, so as to mitigate cellular stress and facilitate recovery.

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