Abstract:
In traumatic brain injury sudden mechanical impacts cause diffuse axonal injury to central neurons. Whether axons can proactively resist mechanical stress remains unknown. Using a new microfluidic device, we found that mild mechanical stress causes a restricted and reversible axonal beading, generated by NM-II-driven radial contraction of the axon cortex, reducing its volume by over 20%. Thus, the elevated Ca2+ waves in the stressed axon are suppressed, preventing further axonal degeneration.
| Host: | Prof Wang Hongyan
Principal Investigator & Deputy Programme Director
Neuroscience & Behavioural Disorders Programme, Duke-NUS |
All are welcome. No registration is required.
Date and Time
10 Feb 2023 @ 12:00 - 10 Feb 2023 @ 13:00
Speaker
Dr Tong Iris Wang
Group Leader/Assistant Professor
ShanghaiTech University
China
Dr Wang graduated from the Institute of Neuroscience, Chinese Academy of Sciences in 2011. In 2012, she joined Professor Frederic Meunier's lab at Queensland Brain Institute as a postdoctoral researcher to study the cellular mechanisms that control activity-dependent axon trafficking. Since Sept. 2019, she has started to work at ShanghaiTech as a group leader/assistant professor. Her lab focuses on identifying the new cellular and molecular mechanisms underlying neuronal injuries and degenerations.