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CVR\NBD Research Seminar (Virtual): The role of cholesterol homeostasis in pseudoexfoliation syndrome

Abstract:
Pseudoexfoliation syndrome is characterized by the accumulation of abnormal fibrillar deposits in the front of the eye. This is a common cause of glaucoma and a major cause of irreversible blindness worldwide. To date, it is unclear from where, and how this deposition occurs. Here, I will present data from our recent large-cohort exon sequencing campaign which suggests that altered cholesterol homeostasis could be a key player in driving this pathogenic deposition in the eye.

Meeting ID: 897 6775 9903 
Password: 259170
https://nus-sg.zoom.us/j/89767759903pwd=YVlzeXlLdEpWWDFLeGpWNE1pVjF4UT09


Host:
Prof Jonathan Crowston
Director
Centre for Vision Research
Neuroscience and Behavioural Disorder Programme, Duke-NUS

Contact Person:
Jacqueline Ho (jacqueline.ho@duke-nus.edu.sg)
Neuroscience & Behavioural Disorders Programme, Duke-NUS


Date and Time


23 Feb 2021 @ 12:00 - 23 Feb 2021 @ 13:00

Speaker


Wang Zhenxun_photo
















Dr Wang Zhenxun

Research Scientist, Genome Institute of Singapore  
Adj Asst Professor, Centre for Vision Research

Dr Wang obtained his PhD from Cold Spring Harbor Laboratory in 2012. As a postdoctoral fellow at the Genome Institute of Singapore, he discovered druggable metabolic dependencies in cancer stem cells. More recently, he has pivoted to the field of functional genomics and is currently working towards deciphering the roles of glaucoma risk genes in glaucoma pathophysiology.