Chee, Michael

MBBS

Professor

Neuroscience & Behavioural Disorders Programme

+65 6516 4916

+65 6221 8625

Email 1:

michael.chee@duke-nus.edu.sg

http://centre4cogneurosci.org/

Research Bio Container

Research

Research Interest:

My lab studies cognition in the context of sleep deprivation and healthy cognitive aging. The common thread linking these seemingly unrelated themes is the goal of furthering human cognitive performance through an understanding of the mechanisms that underlie performance degradation in these settings.

Sleep Deprivation

My lab has contributed to a better understanding of the neural correlates of cognitive alterations associated with short-term total sleep deprivation (TSD) on healthy young adults Using a combination of behavioral tests, EEG and functional magnetic resonance imaging (fMRI), we have probed the mechanisms underlying reduced attention and processing capacity as well as changes to decision making and valuation. We have probed the imaging correlates of inter-individual variation in performance when volunteers are under sleep deprived. We seek to extend this work to partial sleep deprivation and to evaluate the benefits of sleep extension on cognition and human health.

Healthy Brain Aging

The goal of studying the healthy aging brain is to characterize the extent to which modifiable risk factors result in either positive or deleterious effects on brain morphology and function.

The lab has a cohort of around 350 healthy elderly (age 55-85 years) of Chinese ethnicity who have been followed up for 4 years. We are currently into wave 3 of a longitudinal study and are collecting structural MR, DTI and resting state data.

In wave 4 we will examine sleep structure, quality and how this affects cognition and brain structure. Additionally, we will evaluate risky decision-making in elderly persons and how this compares with young adults in the local cultural milieu.

Selected Publications:

Huang S, Deshpande A, Yeo SC, Lo JC, Chee MWL, Gooley JJ. Sleep Restriction Impairs Vocabulary Learning when Adolescents Cram for Exams. The Need for Sleep Study. 2016 Sep 1. 39(9): 1681-1690.

Poh JH, Chong PL, Chee MWL. Sleepless Night, Restless Mind: Effects of Sleep Deprivation on Mind Wandering. 2016 Jun 30. Journal of Experimental Psychology: General. doi: 10.1037/xge0000207

Wang C, Ong JL, Patanaik A, Zhou J, Chee MWL. Spontaneous eyelid closures link vigilance fluctuation with fMRI dynamic connectivity states. Proceedings of the National Academy of Sciences. 2016 Aug 10. doi: 10.1073/pnas.1523980113

Massar SAA, Lim J, Sasmita KS, Chee MWL. Rewards Boost Sustained Attention through Higher Effort: A Value-based Decision Making Approach. Biological Psychology. 2016 Aug 4; 120: 21–27.

Ong JL, Lo JC, Gooley JJ, Chee MW. EEG changes across multiple nights of sleep restriction and recovery in adolescents: The Need for Sleep study. SLEEP. 2016 Jun 1; 39(6):1233-1240.

Lim J, Teng J, Wong KF, Chee MWL. Modulating rest-break length induces differential recruitment of automatic and controlled attentional processes upon task reengagement. Neuroimage. 2016 Mar 31; 134:64-73.

Ong JL, Lo JC, Chee NIYN, Santostasi G, Paller KA, Zee PC, Chee MWL. Effects of phase-locked acoustic stimulation during a nap on EEG spectra and declarative memory consolidation. Sleep Medicine. 2016 Apr 1; 20:88-97.

Chee MWL. Fragmented sleep and cortical thinning in old adults: time to wake up?. SLEEP. 2016 Jan 1; 39(1):15-17.

Lo JC, Ong JL, Leong RL, Gooley JJ, Chee MWL. Cognitive Performance, Sleepiness, and Mood in Partially Sleep Deprived Adolescents: The Need for Sleep Study. SLEEP. 2016 Mar 1; 39(3): 687–698.

Lo JC, Groeger JA, Cheng GH, Dijk DJ, Chee MWL. Self-reported sleep duration and cognitive performance in older adults: a systematic review and meta-analysis. Sleep Medicine. 2016 Jan 1; 17:87-98.

Ng KK, Lo JC, Lim JKW, Chee MWL, Zhou J, Reduced functional segregation between the default mode network and the executive control network in healthy older adults: A longitudinal study. Neuroimage. 2016 Mar 19; 133:321-330.

Van Someren EJW, Cirelli C, Dijk DJ, Van Cauter E, Schwartz S, Chee MWL. Disrupted Sleep: From Molecules to Cognition. The Journal of Neuroscience. 2015 Oct 14; 35(41): 13889-13895.

Kong D, Asplund CL, Ling A, Chee MWL. Increased automaticity and altered temporal preparation following sleep deprivation. SLEEP. 2015 Sep 1; 38(8):1219–1227.

Massar SAA and Chee MWL. Preserved calibration of persistence based on delay-timing distribution during sleep deprivation. Journal of Sleep Research. 2015 Jul 14. doi: 10.1111/jsr.12325.

Massar SAA, Libedinsky C, Weiyan C, Huettel SA, Chee MWL. Separate and overlapping brain areas encode subjective value during delay and effort discounting. Neuroimage. 2015 Jul 8; 120:104-113.

Chee MWL. Limitations on visual information processing in the sleep-deprived brain and their underlying mechanisms. Current Opinion in Behavioral Sciences. 2015 Feb 1; 1: 56-63. http://dx.doi.org/10.1016/j.cobeha.2014.10.003.

Ong JL, Kong D, Chia TTY, Tandi J, Yeo BTT, Chee MWL. Co-activated yet disconnected—Neural correlates of eye closures when trying to stay awake. Neuroimage. 2015 May 24; doi:10.1016/j.neuroimage.2015.03.085.

Klauser P, Zhou J, Lim JK, Poh JS, Zheng H, Tng HY, Krishnan R, Lee J, Keefe RS, Adcock AR, Wood SJ, Fornito A, Chee MWL. Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study. Schizophrenia Bulletin. 2015 May 4; doi:10.1093/schbul/sbv012.

Patanaik A, Kwoh CK, Chua EC, Gooley JJ, Chee MWL. Classifying Vulnerability to Sleep Deprivation Using Baseline Measures of Psychomotor Vigilance. SLEEP. 2015 May 1; 38(5): 723-734.

Yeo BTT, Tandi J, Chee MWL. Functional connectivity during rested wakefulness predicts vulnerability to sleep deprivation. Neuroimage. 2015 May 1; 111: 147-158.

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Chee, Michael

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Duke-NUS Medical School

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