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CVR Staff



Chrysostomou Vicki

Senior Research Fellow

Email

Contact: 66013854

Dr Chrysostomou obtained her doctoral studies on retinal degenerative disease at the Australian National University, Canberra, Australia in 2009. Her focus over the past 5 years has been to develop and lead a project investigating the impact of exercise on the aged retina and optic nerve, and its response to injury.

Dr Chrysostomou's key research aim is to understand the role of ageing in glaucoma and from this to develop new therapeutic targets. Her research uses rodent models of retinal injury and specializes in the techniques of electrophysiology to record retinal function, in combination with anatomical/biochemical analyses of retinal tissue such as immunocytochemistry, histology and protein/gene expression assays.

Upon completion of her studies, she worked as a Postdoctoral Research Fellow at the Glaucoma Research Unit at the Centre for Eye Research Australia (CERA), Melbourne Australia until 2019.

  1. Li, F., Hung, S.S.C., Mohd Khalid, M.K.N., Wang, J.H., Chrysostomou, V., Wong, V.H.Y., Singh, V., Wing, K., Tu, L., Bender, J.A., Pebay, A., King, A.E., Cook, A.L., Wong, R.C.B., Bui, B.V., Hewitt, A.W. & Liu, G.S. Utility of Self-Destructing CRISPR/Cas Constructs for Targeted Gene Editing in the Retina. Hum. Gene Ther. (2019).
  2. Cimdins, K., Waugh, H.S., Chrysostomou, V., Lopez Sanchez, M.I.G., Johannsen, V.A., Cook, M.J., Crowston, J.G., Hill, A.F., Duce, J.A., Bush, A.I. & Trounce, I.A. Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity. Mol. Neurobiol. 56, 5471-5482 (2019).
  3. Chrysostomou, V., Hatch, R.J., Colgan, T., Paul, J.P., van Wijngaarden, P., Trounce, I., Lopez Sanchez, M.I.G., Bell, K., Grus, F. & Crowston, J.G. Visual recovery as the target for glaucoma. Ophthalmologe 116, 14-17 (2019).
  4. Balachandra, A., Chan, E.C., Paul, J.P., Ng, S., Chrysostomou, V., Ngo, S., Mayadunne, R. & van Wijngaarden, P. A biocompatible reverse thermoresponsive polymer for ocular drug delivery. Drug Deliv 26, 343-353 (2019).
  5. Fry, L.E., Fahy, E., Chrysostomou, V., Hui, F., Tang, J., van Wijngaarden, P., Petrou, S. & Crowston, J.G. The coma in glaucoma: Retinal ganglion cell dysfunction and recovery. Prog. Retin. Eye Res. 65, 77-92 (2018).
  6. Crowston, J.G., Fahy, E.T., Fry, L., Trounce, I.A., van Wijngaarden, P., Petrou, S. & Chrysostomou, V. Targeting retinal ganglion cell recovery. Eye 31, 196-198 (2017).
  7. Chrysostomou, V., van Wijngaarden, P., Steinberg, G.R. & Crowston, J.G. A short term high-fat high-sucrose diet in mice impairs optic nerve recovery after injury and this is not reversed by exercise. Exp. Eye Res. 162, 104-109 (2017).
  8. Hung, S.S.C., Chrysostomou, V., Li, F., Lim, J.K.H., Wang, J.-H., Powell, J.E., Tu, L., Daniszewski, M., Lo, C., Wong, R.C., Crowston, J.G., Pébay, A., King, A.E., Bui, B.V., Liu, G.-S. & Hewitt, A.W. AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In VivoAAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells. Invest. Ophthalmol. Vis. Sci. 57, 3470-3476 (2016).
  9. Fahy, E.T., Chrysostomou, V. & Crowston, J.G. Mini-Review: Impaired Axonal Transport and Glaucoma. Curr. Eye Res. 41, 273-283 (2016).
  10. Fahy, E.T., Chrysostomou, V., Abbott, C.J., van Wijngaarden, P. & Crowston, J.G. Axonal transport along retinal ganglion cells is grossly intact during reduced function post-injury. Exp. Eye Res. 146, 289-292 (2016).
  11. Chrysostomou, V., Galic, S., van Wijngaarden, P., Trounce, I.A., Steinberg, G.R. & Crowston, J.G. Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway. Aging Cell 15, 1082-1091 (2016).
  12. Crowston, J.G., Kong, Y.X.G., Trounce, I.A., Dang, T.M., Fahy, E.T., Bui, B.V., Morrison, J.C. & Chrysostomou, V. An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse. Exp. Eye Res. 141, 3-8 (2015).
  13. Crombie, D.E., Van Bergen, N., Davidson, K.C., Anjomani Virmouni, S., McKelvie, P.A., Chrysostomou, V., Conquest, A., Corben, L.A., Pook, M.A., Kulkarni, T., Trounce, I.A., Pera, M.F., Delatycki, M.B. & Pébay, A. Characterization of the retinal pigment epithelium in Friedreich ataxia. Biochemistry and Biophysics Reports 4, 141-147 (2015).
  14. Chrysostomou, V., Kezic, J.M., Trounce, I.A. & Crowston, J.G. Forced exercise protects the aged optic nerve against intraocular pressure injury. Neurobiol. Aging 35, 1722-1725 (2014).
  15. Kezic, J.M., Chrysostomou, V., Trounce, I.A., McMenamin, P.G. & Crowston, J.G. Effect of Anterior Chamber Cannulation and Acute IOP Elevation on Retinal Macrophages in the Adult Mouse. Invest. Ophthalmol. Vis. Sci. 54, 3028-3036 (2013).
  16. Chrysostomou, V., Rezania, F., Trounce, I.A. & Crowston, J.G. Oxidative stress and mitochondrial dysfunction in glaucoma. Current Opinion in Pharmacology 13, 12-15 (2013).
  17. Chrysostomou, V. & Crowston, J.G. The Photopic Negative Response of the Mouse Electroretinogram: Reduction by Acute Elevation of Intraocular Pressure. Invest. Ophthalmol. Vis. Sci. 54, 4691-4697 (2013).
  18. Lee, S., Sheck, L., Crowston, J.G., Van Bergen, N.J., O'Neill, E.C., O'Hare, F., Kong, Y.X.G., Chrysostomou, V., Vincent, A.L. & Trounce, I.A. Impaired complex-I-linked respiration and ATP synthesis in Primary Open-Angle Glaucoma patient lymphoblasts. Invest. Ophthalmol. Vis. Sci. 53, 2431-2437 (2012).
  19. Kong, Y.X.G., van Bergen, N., Bui, B.V., Chrysostomou, V., Vingrys, A.J., Trounce, I.A. & Crowston, J.G. Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury. Neurobiol. Aging 33, 1126 (2012).
  20. Natoli, R., Valter, K., Chrysostomou, V., Stone, J. & Provis, J. Morphological, functional and gene expression analysis of the hyperoxic mouse retina. Exp. Eye Res. 92, 306-314 (2011).
  21. Lee, S., Van Bergen, N.J., Kong, G.Y., Chrysostomou, V., Waugh, H.S., O'Neill, E.C., Crowston, J.G. & Trounce, I.A. Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies. Exp. Eye Res. 93, 204-212 (2011).
  22. Kong, Y.X.G., Van Bergen, N., Trounce, I.A., Bui, B.V., Chrysostomou, V., Waugh, H., Vingrys, A. & Crowston, J.G. Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury. Aging Cell 10, 572-583 (2011).
  23. Chrysostomou, V., Trounce, I.A. & Crowston, J.G. Mechanisms of retinal ganglion cell injury in aging and glaucoma. Ophthalmic Res. 44, 173-178 (2010).
  24. Chrysostomou, V., Stone, J. & Valter, K. Differences in photoreceptor sensitivity to oxygen stress between Long Evans and Sprague-Dawley rats. Adv. Exp. Med. Biol. 664, 473-479 (2010).
  25. Chrysostomou, V., Valter, K. & Stone, J. Cone-rod dependence in the rat retina: Variation with the rate of rod damage. Invest. Ophthalmol. Vis. Sci. 50, 3017-3023 (2009).
  26. Chrysostomou, V., Stone, J. & Valter, K. Life history of cones in the rhodopsin-mutant P23H-3 rat: Evidence of long-term survival. Invest. Ophthalmol. Vis. Sci. 50, 2407-2416 (2009).
  27. Chrysostomou, V., Stone, J., Stowe, S., Barnett, N.L. & Valter, K. The status of cones in the rhodopsin mutant P23H-3 retina: Light-regulated damage and repair in parallel with rods. Invest. Ophthalmol. Vis. Sci. 49, 1116-1125 (2008).