Tenure Track Faculty Staff Details

Faculty
Tenure Track Faculty
Tenure Track Faculty Staff Details

Ooi Yaw Shin

Assistant Professor, Signature Research Programme in Emerging Infectious Diseases

yawshin.ooi@duke-nus.edu.sg

About

Publications

Bio

Yaw Shin is an Assistant Professor in the Emerging Infectious Diseases (EID) program at Duke-NUS Medical School. He received his doctorate from Albert Einstein College of Medicine (Mentor: Margaret Kielian), New York, and later pursued his postdoctoral training at Stanford University (Mentor: Jan Carette), California. He has a long-established interest in discovering cellular factors (host dependency factors and restrictions factors) that determine susceptibility and permissivity to virus infections. Host dependency factors are keys hijacked by viruses to penetrate cellular barriers and rewire host cells for promoting viral protein translation, genome replication, assembly, exit, and spread. In contrast, viruses must evade antiviral innate immunity to avoid tolls during the infection process, especially by antagonizing host restriction factors. Currently, his team's focus is centered on mosquito-borne RNA viruses and human respiratory RNA viruses – all pose serious threats to global public health.

For more information, please visit our lab website.

Education

Doctor of Philosophy

Yeshiva University, United States

Master of Science

Yeshiva University, United States

Master of Science

University of Malaya, Malaysia

BSc (Genet & Molecular Bio) Hons w Dist

University of Malaya, Malaysia

Tenure Track Faculty Staff Details

Bio

Education

Doctor of Philosophy

Master of Science

Master of Science

BSc (Genet & Molecular Bio) Hons w Dist

Publications

An RNA-Centric Dissection of Host Complexes Controlling Flavivirus Infection.

Enterovirus Pathogenesis Requires the Host Methyltransferase SETD3.

A memory of eS25 loss drives resistance phenotypes.

TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection.

Loquacious modulates flaviviral RNA replication in mosquito cells. PLoS Pathog 18

The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.

A fast-growing dengue virus mutant reveals a dual role of STING in response to infection.

Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor.

Mass Spectrometry-based Lipidomics, Lipid Bioenergetics, and Web Tool for Lipid Profiling and Quantification in Human Cells.

Characterization of Effect of Enterovirus D68 in 129/Sv Mice Deficient in IFN-α/β and/or IFN-γ Receptors.

GeneRaMeN enables integration, comparison, and meta-analysis of multiple ranked gene lists to identify consensus, unique, and correlated genes.

Studies of C57BL/6J mice Deficient in Receptors for Interferon α/β and –γ as a Model for EV-D68 Acute Flaccid Myelitis.

Identification of Host Factors of Paramyxoviruses by siRNA Genome-Wide Screens.

A review of virus host factor discovery using CRISPR screening.

Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses.

MFSD6 is an entry receptor for respiratory enterovirus D68.

Tenure Track Faculty Staff Details

Bio

Education

Doctor of Philosophy

Master of Science

Master of Science

BSc (Genet & Molecular Bio) Hons w Dist

Publications

An RNA-Centric Dissection of Host Complexes Controlling Flavivirus Infection.

Enterovirus Pathogenesis Requires the Host Methyltransferase SETD3.

A memory of eS25 loss drives resistance phenotypes.

TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection.

Loquacious modulates flaviviral RNA replication in mosquito cells. PLoS Pathog 18

The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.

A fast-growing dengue virus mutant reveals a dual role of STING in response to infection.

Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor.

Mass Spectrometry-based Lipidomics, Lipid Bioenergetics, and Web Tool for Lipid Profiling and Quantification in Human Cells.

Characterization of Effect of Enterovirus D68 in 129/Sv Mice Deficient in IFN-α/β and/or IFN-γ Receptors.

GeneRaMeN enables integration, comparison, and meta-analysis of multiple ranked gene lists to identify consensus, unique, and correlated genes.

Studies of C57BL/6J mice Deficient in Receptors for Interferon α/β and –γ as a Model for EV-D68 Acute Flaccid Myelitis.

Identification of Host Factors of Paramyxoviruses by siRNA Genome-Wide Screens.

A review of virus host factor discovery using CRISPR screening.

Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses.

MFSD6 is an entry receptor for respiratory enterovirus D68.

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