Vasudevan Subhash

Professor

Email

Contact: 65166718

Education 

La Trobe University, BSc (Hons), 1985

Australian National University, PhD, 1989


Professional Experience

Editor, Antiviral Research 2010 - 

Head of Dengue, Novartis Institute for Tropical Diseases 2003 – 2008

Reader, Department of Biochem & Mol Biol James Cook University, Australia 2001 - 2002 

Senior Lecturer, Department of Biochem & Mol Biol James Cook University, Australia 1997-2000

Lecturer, Department of Biochem & Mol Biol James Cook University, Australia 1993 - 1996

Post-doctoral Fellow, Research School of Chemistry, ANU 1991 - 1992  

EMBO short term fellow, National Institute for Medical Research, Mill Hill, London 1991

Post-doctoral Fellow, Dept of Membrane Molecular Biology, Max Planck Institute 1989-1991

Awards and Fellowships

1. Viral protein structure and function

2. Drug discovery and development for emerging infectious diseases

3. Animal models for flaviviral infection and therapeutics studies

A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice. Chan KWK, Watanabe S, Jin JY, Pompon J, Teng D, Alonso S, Vijaykrishna D, Halstead SB, Marzinek JK, Bond PJ, Burla B, Torta F, Wenk MR, Ooi EE, Vasudevan SG. Sci Transl Med. 2019 Jun 26;11(498). pii: eaat7726. doi: 10.1126/scitranslmed.aat7726

Chacko AM, Watanabe S, Herr KH, Kalimuddin S, Tham JY, Ong J, Reolo M, Serrano R, Cheung YB, Low JG and Vasudevan SG (2017) 18F-FDG as an Inflammation Biomarker for Imaging Dengue Virus Infection and Treatment. J Clin. Investigations Insight 4;2(9). pii: 93474.

Tay MY, Smith K, Ng IH, Chan KW, Zhao Y, Ooi EE, Lescar J, Luo D, Jans DA, Forwood JK, Vasudevan SG. (2016) The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. PLoS Pathogens 12(9):e1005886.

Zhao, Y., Soh, T. S., Zheng, J., Chan, K. W. K., Phoo, W. W., Lee, C. C., Tay, M. Y. F., Swaminathan, K., Cornvik, T. C., Lim, S. P., Shi, P. Y., Lescar, J., Vasudevan, S. G., Luo, D. (2015). A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication. PLoS Pathogens, 11(3), e1004682.

Zhao, Y., Soh, T. S., Chan, K. W. K., Fung, S. S. Y., Swaminathan, K., Lim, S. P., Shi, P-Y., Huber, T., Lescar, J., Luo, D., Vasudevan, SG (2015). Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication. Journal of Virology, 89(20), 10717-10721.

Watanabe, S., Chan, K. W. K., Wang, J., Rivino, L., Lok, S. M., Vasudevan, SG (2015). Dengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice. Journal of Virology, 89(11), 5847-5861.

Low, J. G., Sung, C., Wijaya, L., et al., Vasudevan, S. G. (2014). Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial. The Lancet Infectious Diseases, 14(8), 706-715.

Schul, W., Liu, W., Xu, H. Y., Flamand, M., Vasudevan, S. G. (2007). A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. Journal of Infectious Diseases, 195(5), 665-674.

Fink, J., Gu, F., Ling, L., Tolfvenstam, T., Olfat, F., Chin, K. C., Aw, P., George, G., Kuznetsov, V. A., Schreiber, M., Vasudevan, S. G., Hibberd, M. L. (2007). Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Neglected Tropical Diseases, 1(2), e86.

Yap, T. L., Xu, T., Chen, Y. L., Malet, H., Egloff, M. P., Canard, B., Vasudevan, S. G., Lescar, J. (2007). Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. Journal of Virology, 81(9), 4753-4765.

Erbel, P., Schiering, N., D'Arcy, A., Renatus, M., Kroemer, M., Lim, S. P., Yin, Z., Keller, T. H., Vasudevan, S. G., Hommel, U. (2006). Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nature Structural & Molecular Biology, 13(4), 372-373.