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Centre for Computational Biology



Chen Huimei

Senior Research Fellow

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With systemic analysis in genetic and transcriptional data, Huimei has identified the risk gene associated with fibrotic diseases, such as cardiac fibrosis, kidney fibrosis, and brain diseases. She tries to illustrate their roles involved with suitable In vitro and In vivo models. WWP2 is taken as a promising gene target and continued into drug development  for tissue fibrosis.

  1. Ding QJ, Zhao WW, Long JR, Alsafar H, Zhou Q, Chen HM*. Cis-regulation of antisense noncoding RNA at the JAZF1 locus in type 2 diabetes. J Gene Med. 2022 2; e3407.
  2. Ding QJ, Kucharczyk R, Zhao WW, Dautant A, Xu ST, Niedzwiecka K, Su X, Marie- Giraud F, Gombeau K, Zhang MC, Xie HL, Zeng CH, Bouhier M, di Rago JP, Liu ZH, Tribouillard-Tanvier D*, Chen HM*. Case Report: Identification of a Novel Variant (m.8909T>C) of Human Mitochondrial ATP6 Gene and Its Functional Consequences on Yeast ATP Synthase. Life (Basel). 2020; 10(9): 215.
  3. Ding QJ, Amelia T, E.J. Parra, Miguel C, XL Sim, YY Teo, JR Long, Alsafer H, Enrico P, ES Tai, Chen HM*. Genome-wide meta-analysis associates GPSM1 with type 2 diabetes, a plausible gene involved in skeletal muscle function. J Hum Gen: 65: 411-420, 2020
  4. Chen H#, Moreno-Moral A#, Pesce F, Devapragash N, Mancini M, Heng EL, Rotival M, Srivastava PK, Harmston N, Shkura K, Rackham OJL, Yu WP, Sun XM, Tee NGZ, Tan ELS, Barton PJR, Felkin LE, Lara-Pezzi E, Angelini G, Beltrami C, Pravenec M, Schafer S, Bottolo L, Hubner N, Emanueli C, Cook SA, Petretto E. WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling. Nat Commun. 2019 ;10(1):3616.
  5. Bai M, Chen H (co-first), Ding D, Song R, Lin J, Zhang Y, Guo Y, Chen S, Ding G, Zhang Y, Jia Z, Huang S, He JC, Yang L, Zhang A. MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation. Kidney Int. 2019 Jun;95(6):1389-1404.
  6. Zhao WW, Ding Y, Lu JP, Zhang T, Chen DC, Zhang HT, Zeng CH, Liu ZH, Chen HM*. Genetic analysis of complement pathway in C3 glomeruopathy. Nephrology Dialysis Transplantation. 2018 1-9
  7. Zhou Y, Chen H(co-first), Liu L, Yu X, Sukhova GK, Yang M, Kyttaris VC, Stillman IE, Gelb B, Libby P, Tsokos GC, Shi GP. Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice. J Immunol. 2017 Mar 1;198(5):1846-1854.
  8. Ding Y, Zhao W, Zhang T, Qiang H, Lu J, Su X, Wen S, Xu F, Zhang M, Zhang H, Zeng C, Liu Z, Chen H*. A haplotype in CFH family genes confers high risk of rare glomerular nephropathies. Sci Rep. 2017 Jul 20;7(1):6004.
  9. Yan RN, Lai SS, Yang Y, Shi HF, Cai ZM, V. Sorrentino, Du H*, Chen HM*. A novel type 2 diabetes risk allele increases the promoter activity of the muscle-specific small ankyrin 1 gene. Scientific Reports, 6:25105, 2016
  10. Zhou Y, Yu XQ, Chen HM, Sjo¨ berg S, Roux, Zhang LJ, Ivoulsou AH, Bensaid F, Liu CX, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, Shi GP*, Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages, Cell Metabolism, 22(6): 1045-1058, 2015
  11. Wang J, Sun CX, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen HM, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP*. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015 21(7): 820-6.
  12. Zhang CM, Zhang WF, Chen HM, Liu CB, Wu JN, Shi SL, Liu ZH*. Plasme MicroRNA-186 and proteinuria in focal segmental glomerulosclerosis. Am J Kidney Dis. 2014, 11(14): 01083-X.
  13.  Zhang WF, Zhang CM, Chen HM, Li L, Tu YM, Liu CB, Shi SL, Zen K*, Liu ZH*. Evaluation of MicroRNAs miR-196a, miR-30a-5P, and miR-490 as Biomarkers of Disease Activity among Patients with FSGS. Clin J Am Soc Nephrol. 2014; 9(9):1545-52.
  14. Zhang J, Chen HM (co-first author), Liu L, Sun JS, Shi MA, Sukhova GK, Shi GP. Chemokine (C-C motif) receptor 2 mediates mast cell migration to abdominal aortic aneurysm lesions in mice. Cardiovasc Res.; 96(3):543-51, 2012
  15. Chen HM, Sun CX, Guo WW, Meng R, Du H, Qi QF, Gu X, Li LR, Zhang K, Zhu DL, Wang YP. AluYb8 insertion in the MUTYH Gene is related to increased 8-OHdG in genomic DNA and could be a risk factor for type 2 diabetes in a Chinese population. Mol Cell Endocrinol, 332:301-5. 2011,
  16. Sun CX, Chen HM (co-first author), Guo WW, Zhang K, Qi QF, Gu X, Zhu DL, Wang YP. A common mutation of the MYH gene is associated with increased DNA oxidation and age-related diseases. Free Radic Biol Med. 48: 430-6, 2010.
  17. Shen WW, Chen HM, Chen H, Xu F, Li LS, Liu ZH. Obesity-Related Glomerulopathy: Body Mass Index and Proteinuria. Clin J Am Soc Nephrol. 5: 1401-1409, 2010
  18. Chen HM, Li SJ, Chen HP, Wang QW, Li LS, Liu ZH: Obesity-related glomerulopathy in China: a case series of 90 patients. Am J Kidney Dis, 52:58-65, 2008.
  19. Zeng CH, Chen HM, Wang RS, Chen Y, Zhang SH, Liu L, Li LS, Liu ZH. Etiology and Clinical Characteristics of Membranous Nephropathy. Am J Kidney Dis 2: 691-698, 2008
  20. Chen HM, Liu ZH, Zeng CH, Li SJ, Wang QW, Li LS: Podocyte lesions in patients with obesity-related glomerulopathy. Am J Kidney Dis 48:772-779, 2006.