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Centre for Computational Biology



Swarnaseetha Adusumalli

Research Fellow

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Seetha is experienced in high-throughput -omics data analysis and integration. She works closely with Prof Karl Tryggvason’s lab, to study the differentiation process of cardiomyocytes and photoreceptors using single-cell and spatial transcriptomics in laminin cultured cells.

  1. Adusumalli S, Mohd Omar MF, Soong R, Benoukraf T. “Methodological aspects of whole genome bisulfite sequencing analysis”. Brief Bioinform. 2014 May 27. doi:10.1093/bib/bbu016. PMID: 24867940. 
  2. Adusumalli S, Lee HT, Qiangze H, SL Koo, IB Tan, Ng PC. “Assessment of Online Consumer Reviews as a Resource for Drug Performance.” J Med Internet Res. 2015;17(8):e211. doi:10.2196/jmir.4396. PMID: 26319108. 
  3. Vaseer R*, Adusumalli S*, Sim NL, Sicik M, Ng PC. “SIFT Missense Predictions for Genomes.” Nature Protocols 2016; 11:1-9. PMID: 26633127.
  4. Adusumalli S, Ngian ZK, Lin WQ, Benoukraf T, Ong CT. “Increased intron retention is a post-transcriptional signature associated with progressive aging and Alzheimer’s disease”. Aging Cell. 2019 Mar 13:e12928. doi:10.1111/acel.12928. PMID: 30868713. 
  5. Vinay Kumar Rao*, Adusumalli S*, Tham GH*, Lin WQ, Benoukraf T, Guo-Liang Xu, Ong CT. “Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation”. Nucleic Acids Research, Volume 48, Issue 3, 20 February 2020, Pages 1225–1238, https://doi.org/10.1093/nar/gkz1144. PMID: 31807777.
  6. Ong CT & Adusumalli S. “Increased intron retention is linked to Alzheimer’s disease”. Neural Regen Res. 2020 Feb; 15(2): 259–260. doi: 10.4103/1673-5374.265549. PMID: 31552894.
  7. Lynn Yap, Li Yen Chong, Clarissa Tan, Swarnaseetha Adusumalli, Millie Seow, Jing Guo, Zuhua Cai, Sze Jie Loo, Eric Lim, Narayan Lath, Lei Ye, Enrico Petretto, Karl Tryggvason. Pluripotent Stem Cell-Derived Cardiovascular Progenitors Differentiated On Laminin 221 Regenerate And Improve Function Of Infarcted Swine Hearts. BioRxiv. doi: https://doi.org/10.1101/2021.04.29.441908
  8. *Co-first author/equal contribution