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Centre for Computational Biology



Choo Xin Yi

Senior Research Fellow

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Xin Yi graduated from The University of Melbourne with a BH-BMed (Hons), majoring in Pathology. She continued her Ph.D. at the University of Melbourne where she trained with Dr Anthony R. White where she studied metallo-complexes as potential therapeutic treatment for Alzheimer’s disease and Dr Jose M. Polo to study microglia heterogeneity in Alzheimer’s disease.

Back in Singapore, Xin Yi joined the Rackham lab at Duke-NUS in 2019 to understand transcription factor driven cell differentiation and trans-differentiation using CRISPR technology.

When out of the lab, she enjoys travelling, outdoor activities and music.

Grubman, A.*, Choo, X. Y.*, Chew, G., Ouyang*, J. F., Sun, G., Croft, N. P., . . . Polo, J. M. (2021). Transcriptional signature in microglia associated with Aβ plaque phagocytosis. Nature Communications, 12(1), 3015. doi:10.1038/s41467-021-23111-1

Choo, X. Y., Lim, Y. M., Katwadi, K., Yap, L., Tryggvason, K., Sun, A. X., . . . Rackham, O. J. L. (2021). Evaluating Capture Sequence Performance for Single-Cell CRISPR Activation Experiments. ACS Synthetic Biology. doi:10.1021/acssynbio.0c00499

Liu, X.*, Ouyang, J. F.*, Rossello, F. J.*, Tan, J. P., Davidson, K. C., Valdes, D. S., . . . Polo, J. M. (2020). Reprogramming roadmap reveals route to human induced trophoblast stem cells. Nature, 586(7827), 101-107. doi:10.1038/s41586-020-2734-6

Grubman, A.*, Chew, G.*, Ouyang, J. F.*, Sun, G., Choo, X. Y., McLean, C., . . . Polo, J. M. (2019). A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation. Nat Neurosci, 22(12), 2087-2097. doi:10.1038/s41593-019-0539-4

Choo, X. Y.*, Liddell, J. R.*, Huuskonen, M. T.*, Grubman, A., Moujalled, D., Roberts, J., . . . Kanninen, K. M. (2018). Cu(II)(atsm) Attenuates Neuroinflammation. Front Neurosci, 12, 668. doi:10.3389/fnins.2018.00668

Choo, X. Y., & Grubman, A. (2017). Treatment and measurement of metals in brain cell cultures. In Metals in the Brain (Vol. 124, pp. 259-268). (Neuromethods). Humana Press.

Choo, X. Y., & Grubman, A. (2016). Recent Clinical Developments in Alzheimer’s Disease. In A-R. (Ed.), Frontiers in Clinical Drug Research Alzheimer Disorder (Vol. 5, pp. 3-64). (Frontiers in Clinical Drug Research - Alzheimer Disorders). United Arab Emirates: Bentham Science Publishers.