Abstract:
The diverse clinical phenotypes of ASD have hampered the elucidation of pathological mechanisms. Based on iPSCs-derived cerebral organoids from ASD individuals, multiple cell lines and time series scRNA-seq combined with histomorphological analysis showed premature neural differentiation of neural stem cells and decreased expression of Fatty acid binding protein 7 (FABP7) in the ASD organoids. Meanwhile, upregulation of FABP7 rescued improper neural differentiation in the ASD organoids.
| Venue: | Room 7C, Level 7, Duke-NUS |
| Host: | Asst Prof Alfred Sun
Principal Investigator
Neuroscience & Behavioural Disorders Programme, Duke-NUS |
| Contact Person: | Joyceline Ng (joyceline.ng@duke-nus.edu.sg)
Neuroscience & Behavioural Disorders Programme, Duke-NUS |
Date and Time
04 Oct 2023 @ 14:30 - 04 Oct 2023 @ 15:30
Speaker
Prof Liu Yan
Professor in Neuroscience
Institute for Stem Cell and Neural Regeneration
Nanjing Medical University
Dr. Yan Liu is a professor of Nanjing Medical University. She is the winner of National Science Fund for Distinguished Young Scholars. Dr. Yan Liu got her Ph.D degree in Fudan University, and worked as a Postdoc in University of Wisconsin, USA. Dr Yan Liu’s laboratory is focusing on establishing multiple human brain organoids culture systems and studying the neurological disorders. Dr. Yan Liu has published papers in Nat Biotechnol, Nat Commun, J Clin Invest and Mo Psychiatry, etc.