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NBD Seminar Series (Virtual): Mechanisms underlying adult neural stem cell quiescence exit
Abstract:
Maintaining a healthy proteome throughout life is critical for proper somatic stem cell function, yet the complexities of the stem cell response to increases in damaged or aggregated proteins remain unclear. Recently, we have found that adult neural stem cells (NSCs) utilize aggresomes to recover from disrupted proteostasis, using the intermediate filament vimentin as a spatial coordinator of proteasomes to the aggresome.
Join Zoom Meeting:
https://nus-sg.zoom.us/j/84381987985?pwd=Qmx2UEFkTFYyem4vWkpyamx3SE5xUT09
Meeting ID: 843 8198 7985
Passcode: 128118
Host:
Prof Zhang Suchun
Programme Director
Neuroscience & Behavioural Disorders Programme, Duke-NUS
Contact Person:
Jacqueline Ho (jacqueline.ho@duke-nus.edu.sg)
Neuroscience & Behavioural Disorders Programme, Duke-NUS
All are welcome, no registration is required.
Date and Time
08 Oct 2021 @ 11:00 - 08 Oct 2021 @ 12:00
Speaker
Dr Darcie L. Moore, Ph.D.
Assistant Professor
Department of Neuroscience
University of Wisconsin-Madison
USA
Darcie Moore completed her PhD on CNS axon regeneration in Jeffrey Goldberg's lab at the University of Miami, Florida where she identified the KLF family as developmentally regulated transcription factors driving changes in axon growth ability. She performed her postdoc in the Sebastian Jessberger's lab at ETH/University of Zurich in Switzerland where she focused on adult neurogenesis and demonstrated the asymmetric segregation of cellular components during neural stem cell mitosis.