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NBD Seminar Series (Virtual): Ribosomal stalling and toxic aggregation of nascent polypeptides
Abstract:
Ribosomes that translate faulty mRNAs can stall, producing incomplete proteins. The RQC (Ribosome-associate Quality Control), a protein degradation pathway highly conserved in eukaryotes, clears such stalled polypeptides. When the RQC fails, stalled polypeptides form detergent-insoluble toxic aggregates. Dr Choe will discuss the molecular mechanism of the stalled protein aggregation. Notably, growing evidence indicates that ribosomal stalling is associated with neurodegenerative disorders.
Join Zoom Meeting
https://nus-sg.zoom.us/j/87962522388?pwd=Z0xUUk16SEVGdGpRdkl3SE9ZbFBZZz09
Meeting ID: 879 6252 2388
Passcode: 318266
Host:
Assoc Prof Hyunsoo Shawn Je
Principal Investigator
Neuroscience & Behavioural Disorders Programme
Duke-NUS
Contact Person:
Jacqueline Ho (jacqueline.ho@duke-nus.edu.sg)
Neuroscience & Behavioural Disorders Programme, Duke-NUS
Date and Time
25 Mar 2022 @ 11:00 - 25 Mar 2022 @ 12:00
Speaker
Dr Young Jun Choe
Assistant Professor
School of Biological Sciences
Nanyang Technological University
Singapore
Dr Young Jun Choe received his PhD from Seoul National University in Korea, where he studied the mechanism of the aggregation of yeast prion proteins. Subsequently, as a postdoctoral researcher, he attempted to engineer functional amyloid fibrils in the same university. Then he joined the research group of Dr. F. Ulrich Hartl at the Max-Planck-Institute of Biochemistry in Germany to investigate how cells maintain protein homeostasis. He has been studying the fate of incomplete nascent polypeptides that are synthesized at stalled ribosome.