Vincenzo De Paola

Visiting Professor, Signature Research Programme in Neuroscience & Behavioural Disorders

Duke-NUS Medical School

Bio

Dr. Vincenzo De Paola’s research focuses on understanding the mechanisms of synaptic and axonal breakdown that drive cognitive decline in neurodegenerative diseases, and on identifying strategies to promote neural repair.

To dissect these core mechanisms in a human-relevant context, his lab focuses on Down syndrome as a unique model of accelerated, genetically-driven neurodegeneration. His team has developed advanced in vivo platforms using patient-derived induced pluripotent stem cells (iPSCs) to generate self-assembling human cortical circuits. This approach enables direct visualization of developmental and neurodegenerative processes in real time and provides a powerful system for testing novel therapeutic strategies.

Dr. De Paola’s foundational work includes some of the first-ever dynamic observations of synapse formation, elimination, and regeneration in the living brain. This mechanism-focused approach has produced fundamental discoveries, with key findings published in Science and Nature Medicine and the recent development of a patented therapeutic strategy for Down syndrome. Dr. De Paola’s work aims to translate these insights into effective treatments for both Down syndrome and the broader spectrum of neurodegenerative disorders.

He earned his Ph.D. in Molecular and Cellular Neurobiology at the Friedrich Miescher Institut (University of Basel) with Dr. Pico Caroni and was an EMBO Postdoctoral Fellow at Cold Spring Harbor Laboratory with Dr. Karel Svoboda.

Dr. De Paola launched his independent career at Imperial College London, where he secured a major MRC Programme Grant to lead the Neuroplasticity and Disease Group. He earned a tenured position in the Faculty of Medicine in 2013. In 2021, he moved his lab to Duke-NUS Medical School in Singapore to build on his research in a new interdisciplinary environment.

Education

Doctor of Philosophy

University of Basel, Switzerland, Switzerland

NUS Appointment(s)

Full-Time Visiting Professor

Duke-NUS Medical School, Currently Active

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