Duke-NUS - Cancer and Stem Cell Biology

Programme in Cancer & Stem Cell Biology

Director's Message

 

It is a privilege to serve as Director of the Cancer and Stem Cell Biology (CSCB) Programme at Duke-NUS Medical School. CSCB plays an important role in Duke-NUS’s mission to advance academic medicine through discovery, education, and close partnership with the healthcare system.

 

Our programme is rooted in strong, curiosity-driven science. CSCB researchers investigate fundamental questions in cancer and stem cell biology, including cancer resistance, immunotherapy response, metabolic alteration, cellular plasticity, stem cell regulation, and interactions with the tumour microenvironment. We place a strong emphasis on rigorous experimentation, novel discovery, and the application of emerging technologies, while keeping clinical relevance firmly in view.

 

A key motivation for our research stems from the potential for discovery science to improve patient care. Advances in understanding cancer biology can inform how diseases are detected, classified, and treated. This can lead to more precise and effective therapeutic strategies. Through close interactions with clinician-scientists and healthcare partners, we strive to ensure that insights from the laboratory are translated into approaches that can ultimately improve patient outcomes, while clinical challenges continue to shape our research priorities.

 

Collaboration is central to how we function. CSCB brings together basic scientists and clinician-scientists across Duke-NUS, SingHealth, and partner institutions. These collaborations enable team science that spans fundamental discovery, translational research, drug discovery and clinical investigation, and help bridge the gap between biological underpinnings and patient-oriented research.

 

Training and mentorship are priorities of the programme. We commit to providing a supportive and intellectually stimulating culture for early-career researchers, graduate students, postdoctoral fellows, research associates, and trainees across all levels. Our goal is to nurture scientists who think critically, work independently, and collaborate effectively, while gaining an appreciation of how research can influence clinical decision-making and patient care.

 

As CSCB moves forward, we will continue to strengthen interdisciplinary and clinical collaborations, support innovative research, and contribute to the broader educational and research mission of Duke-NUS. We welcome your interest, and we encourage you to learn more about the research and training opportunities offered by our program

 

A/Prof Tam Wai Leong
Director, Programme in Cancer & Stem Cell Biology
Duke-NUS Medical School

 

CSCB Overview

The Programme in Cancer and Stem Cell Biology (CSCB) is one of five founding Signature Research Programmes of the Duke-NUS Medical School. CSCB has a broad scope of research. Our faculty engage in hypothesis-driven basic science and disease-oriented investigation, as well as active drug discovery and innovative clinical trials. We are committed to translation of key findings, and our faculty have moved basic science discoveries from bench to bedside, with clinical trials in multiple cancers driven by discoveries made by CSCB scientists.

Our Vision

Pioneering cancer care through research and education. 

Our Mission

Conducting world-class research and training in cancer and stem cell biology, through leveraging resources and collaborations in Duke-NUS, Singapore, Duke USA, and throughout the world.



Honouring a legacy: Duke-NUS celebrates David Virshup’s 18 years of impact

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Events

Research
04 Feb 2026
Noon NCRIS Seminar: Dr. Jun Zhou - “Microtubule-based cellular structures in development and disease”
Research
08 Jan 2026
3PM Seminar: Dr. Zhe-Sheng (Jason) Chen - “Strategies to overcome drug resistance in cancer”
Research
15 Dec 2025
NCRIS Research in Progress (RIP) Meeting on 15 Dec 2025 (Mon) @12pm
Research
03 Dec 2025
CSCB Seminar by Prof. Tao Lu: VBIM Forward Genetics and Its Application in Novel Cancer Gene Discovery
Research
02 Dec 2025
CSCB Seminar by Dr Guiping Wang: The ecDNA Epigenome: from Permissive Chromatin to Actionable Vulnerability
Research
01 Dec 2025
NCRIS Research in Progress (RIP) Meeting on 1 Dec 2025 (Mon) @12pm

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