PERC Research Pre-hospital & Emergency Centre Duke-NUS Medical School

Research Publications @ PERC

09 Sep 2020 – 05 Jan 2026

2025

1: White AE, Yoon S, Fook-Chong S, Birkenes TS, Ng WM, Naing Win PT, Leong BSH,Jalil NA, Myklebust H, Ong MEH, Siddiqui FJ. Enhanced community first responder support system: protocol of a randomized trial to improve bystandercardiopulmonary resuscitation quality for out-of-hospital cardiac arrest patients. Resusc Plus. 2025 Nov 19;27:101167. doi: 10.1016/j.resplu.2025.101167.PMID: 41437946; PMCID: PMC12721167.

2: Ho AFW, Shin SD, Ong MEH. Pan-Asian Resuscitation Outcomes Study (PAROS): A Living Population Laboratory Transforming Resuscitation Science Across Asia.JACC Asia. 2025 Dec;5(12):1642-1647. doi: 10.1016/j.jacasi.2025.09.016. PMID:41344750.

3: Elangovan S, Cai Y, Mitchell BG, Graves N. Seven-Day vs Four-Day Infusion SetReplacement Interval and Catheter-Related Infections. JAMA Netw Open. 2025 Dec1;8(12):e2546398. doi: 10.1001/jamanetworkopen.2025.46398. PMID: 41329482;PMCID: PMC12673407.

4: Tham KW, Ong IYE, Tan HC, Chong SL, Piragasam R, Wong L, Khoo ZX, Ong GY, Ganapathy S, Chong SL. Predictors of recurrence and renal scarring post-urinary tract infection among young febrile infants. BMC Pediatr. 2025 Nov 27. doi: 10.1186/s12887-025-06322-z. Epub ahead of print. PMID: 41310536.

5: Elangovan S, Murali S, Aravindhan A, Seow CS, Graves N. Systematic review and meta-analysis of outcomes associated with incisional and organ/space surgical site infections in abdominal surgery patients. Antimicrob Resist Infect Control. 2025 Nov 26;14(1):144. doi: 10.1186/s13756-025-01656-w. PMID: 41299649; PMCID: PMC12659278.

6: Li S, Okada Y, Gu W, Chen MH, Do SN, Pham QD, Hoang QT, Ong MEH, Liu N; PAROS Investigators. Leveraging AI and transfer learning to enhance out-of-hospital cardiac arrest outcome prediction in diverse setting. NPJ Digit Med. 2025 Nov 21;8(1):716. doi: 10.1038/s41746-025-02088-x. PMID: 41272039; PMCID: PMC12638872.

7: Teo Z, Lim SW, Soh BZA, Leong BS, Ho AFW. Sudden cardiac arrest cases during the Standard Chartered Singapore Marathon 2023. Singapore Med J. 2025 Nov 7. doi: 10.4103/singaporemedj.SMJ-2025-063. Epub ahead of print. PMID: 41201126.

8: Elangovan S, Graves N. Trends of economic evidence in infection prevention and control practices for hospital-acquired infections. Am J Infect Control. 2025 Nov 4:S0196-6553(25)00705-9. doi: 10.1016/j.ajic.2025.11.002. Epub ahead of print. PMID: 41198031.

9: Lim SL, Li Y, Shahidah N, Ng YY, Arulanandam S, Tan CK, Hong D, Leong BS,Chong Chia MY, Mao DR, Gan HN, Ng WM, Doctor NE, Cao C, Ong MEH; Singapore PAROS Investigators. Forecasting the burden of out-of-hospital cardiac arrest in a rapidly ageing Asian society: a nationwide age-period-cohort analysis in Singapore. Resuscitation. 2025 Nov;216:110875. doi:10.1016/j.resuscitation.2025.110875. Epub 2025 Oct 27. PMID: 41161525.

10: Yeo NXY, Zhou HJ, Lee JH, Caporal P, Roa G JD, González-Dambrauskas S, Ng JPW, Wong Y, Yock-Corrales A, Kazzaz Y, Abbas Q, Chong SL. Identifying Clinical Predictors of Raised Intracranial Pressure in Pediatric Traumatic Brain Injury-A Multinational Initiative. Neurotrauma Rep. 2025 Sep 9;6(1):778-789. doi: 10.1177/2689288X251370703. PMID: 41112114; PMCID: PMC12528845.

11: Ong CY, Xu H, Yuan J, Ng AJJ, Lee JMH, Ong MEH. Impact of the EAGLEcareACT Telehealth Program on Emergency Department Outcomes Among Nursing Home Residents: A Retrospective Cohort Study. J Am Med Dir Assoc. 2025 Dec;26(12):105900. doi: 10.1016/j.jamda.2025.105900. Epub 2025 Oct 22. PMID: 41075828.

12: Jin L, Ong JCL, Elangovan K, Ke Y, Pyle A, Ting DSW, Liu N. Large Language Models in Randomized Controlled Trials Design: Observational Study. J Med Internet Res. 2025 Sep 3;27:e67469. doi: 10.2196/67469. PMID: 41055064; PMCID: PMC12407223.

13: Ning Y, Ong JCL, Cheng H, Wang H, Ting DSW, Tham YC, Wong TY, Liu N. How can artificial intelligence transform the training of medical students and physicians? Lancet Digit Health. 2025 Oct;7(10):100900. doi: 10.1016/j.landig.2025.100900. Epub 2025 Oct 4. PMID: 41047321.

14: Okada Y, Hong KJ, Ong MEH, Shin SD, Song KJ, Park JH, Ro YS, Shahidah N, Lim SL, Siddiqui FJ. Association of Scene Time Interval and Field Arrival to Epinephrine Administration Time with Outcomes in Cardiac Arrest. J Clin Med. 2025 Sep 20;14(18):6645. doi: 10.3390/jcm14186645. PMID: 41010849; PMCID: PMC12470720.

15: Li S, Wang Z, Shang Y, Wu Q, Hong C, Ning Y, Miao D, Ong MEH, Chakraborty B, Liu N. Developing federated time-to-event scores using heterogeneous real-world survival data. Comput Biol Med. 2025 Oct;197(Pt B):111084. doi: 10.1016/j.compbiomed.2025.111084. Epub 2025 Sep 22. PMID: 40976210.

16: Neo TH, White AE, Win PTN, Jalil NABM, Lim SH, Ong MEH. Evaluation of cardiopulmonary resuscitation and automated external defibrillator skill retention with simplified community-based training. Singapore Med J. 2025 Sep 19. doi: 10.4103/singaporemedj.SMJ-2024-251. Epub ahead of print. PMID: 40974054.

17: Li Y, Shahidah N, Neumar RW, Hong D, White AE, Ng YY, Leong BSH, Chia MYC, Gan HN, Mao DR, Ng WM, Doctor NE, Fan H, Cao C, Ong MEH. Cumulative effect of public health interventions on time interval to first chest compression and survival outcomes in out-of-hospital cardiac arrest. Resuscitation. 2025 Nov;216:110827. doi: 10.1016/j.resuscitation.2025.110827. Epub 2025 Sep 12. PMID: 40946901.

18: Pek PP, Fook-Chong SMC, Sudharshan P, Ge Y, Ng YY, Leong BS, Mao DR, Chia MYC, Ng WM, Gan HN, Doctor NE, Tham LP, Shahidah N, White AE, Hong D, Ong MEH. Impact of AEDs and training of smartphone activated volunteers in residential areas on OHCA: a nationwide stepped-wedge implementation trial. Resuscitation. 2025 Dec;217:110826. doi: 10.1016/j.resuscitation.2025.110826. Epub 2025 Sep 12. PMID: 40946899.

19: Zhan SJ, Saffari SE, Ong MEH, Siddiqui FJ. Missing Data in OHCA Registries: How Imputation Methods Affect Research Conclusions-Paper I. J Clin Med. 2025 Sep 8;14(17):6345. doi: 10.3390/jcm14176345. PMID: 40944104; PMCID: PMC12429819.

20: Li S, Li X, Yu K, Wu Q, Miao D, Zhu M, Yan M, Ke Y, D'Agostino D, Ning Y, Wang Z, Shang Y, Liu M, Hong C, Liu N. Bridging Data Gaps in Healthcare: A Scoping Review of Transfer Learning in Structured Data Analysis. Health Data Sci. 2025 Sep 3;5:0321. doi: 10.34133/hds.0321. PMID: 40917080; PMCID: PMC12408193.

21: Joiner A, Ong MEH. Continued resuscitation at the scene versus early transport for refractory out-of-hospital cardiac arrest. Lancet Respir Med. 2025 Oct;13(10):864-865. doi: 10.1016/S2213-2600(25)00210-3. Epub 2025 Aug 22. PMID: 40854322.

22: Li S, Okada Y, Gu W, Chen MH, Ong MEH, Liu N. Transfer Learning Enhances Neurological Outcome Prediction for Out-of-Hospital Cardiac Arrest: Validation Across Diverse Geographic Contexts. Stud Health Technol Inform. 2025 Aug 7;329:1962-1963. doi: 10.3233/SHTI251300. PMID: 40776317.

23: Li S, Wu Q, Li X, Miao D, Hong C, Gu W, Ning Y, Shang Y, Liu N. FairFML: A Unified Approach to Algorithmic Fair Federated Learning with Applications to Reducing Gender Disparities in Cardiac Arrest Outcomes. Stud Health Technol Inform. 2025 Aug 7;329:1848-1849. doi: 10.3233/SHTI251245. PMID: 40776262.

24: Ho JSY, Earnest A, Siddiqui FJ, Hong D, Chia MYC, Poh KK, Leong BS, Ng YY, Ong MEH, Ho AFW; Singapore PAROS Investigators. The risks of out-of-hospital cardiac arrest and mortality on public holidays and weekends: A time-series study. Resuscitation. 2025 Oct;215:110749. doi: 10.1016/j.resuscitation.2025.110749. Epub 2025 Aug 5. PMID: 40754262.

25: Ho AFW, Ho J, Ong M, Aik J; PAROS Singapore Investigators. Influence of ambient temperature and absolute humidity on sudden cardiac arrest in Singapore: a nationwide time-series study. J Epidemiol Community Health. 2025 Nov 10;79(12):954-959. doi: 10.1136/jech-2025-224275. PMID: 40713183.

26: Ong JHM, Lim BJW, Zahrin MABM, Yong IJS, Tan LLL, Mao RHD, Ong MEH, Siddiqui FJ. Ambulance diversion and its use as an ED overcrowding mitigation strategy: Does it work? A scoping review. Int J Emerg Med. 2025 Jul 8;18(1):125. doi: 10.1186/s12245-025-00933-0. PMID: 40629271; PMCID: PMC12239308.

27: Ong JCL, Ning Y, Collins GS, Bitterman DS, Beecy AN, Chang RT, Denniston AK, Freyer O, Gilbert S, de Hond A, Leeuwenberg AM, Zhao L, Lim JCW, Liu M, Liu X, Longhurst CA, Ma Y, Qiu Y, Sarkar R, Sheng B, Singh K, Tan ISK, Tham YC, Thirunavukarasu AJ, Ting DSW, Vogel S, Zhang R, Zhao J, Chapman WW, Shah NH, Moons KGM, Wong TY, Liu N. International partnership for governing generative artificial intelligence models in medicine. Nat Med. 2025 Sep;31(9):2836-2839. doi: 10.1038/s41591-025-03787-4. PMID: 40588674.

28: Ning Y, Liu M, Liu N. ⁠Advancing ethical AI in healthcare through interpretability. Patterns (N Y). 2025 Jun 13;6(6):101290. doi: 10.1016/j.patter.2025.101290. PMID: 40575122; PMCID: PMC12191714.

29: Liu M, Ning Y, Teixayavong S, Liu X, Mertens M, Shang Y, Li X, Miao D, Liao J, Xu J, Ting DSW, Cheng LT, Ong JCL, Teo ZL, Tan TF, RaviChandran N, Wang F, Celi LA, Ong MEH, Liu N. A scoping review and evidence gap analysis of clinical AI fairness. NPJ Digit Med. 2025 Jun 14;8(1):360. doi: 10.1038/s41746-025-01667-2. PMID: 40517148; PMCID: PMC12167363.

30: Siddiqui FJ, Kumar A, Ansah JP, Yuan G, Liu Z, Malhotra R, Ong MEH, Lam SSW. Long-Range Forecasting for Emergency Care Systems in a Highly Dynamic Setting: A Singapore Case Study. J Am Coll Emerg Physicians Open. 2025 May 31;6(4):100184. doi: 10.1016/j.acepjo.2025.100184. PMID: 40510827; PMCID: PMC12162008.

31: Khandelwal P, Okada Y, Ning Y, Hu Z, Ho AFW, Tan KBK, Ong MEH. Association between age and length of stay in the emergency department in a tertiary care hospital: a retrospective observational study. Emerg Med J. 2025 Dec18;43(1):22-29. doi: 10.1136/emermed-2024-214299. PMID: 40441876.

32: Takahashi H, Okada Y, Hong D, Quah D, Leong BS, Ng YY, Shahidah N, Goh GS, Yazid M, Suzuki K, Neumar RW, Ong MEH; Singapore PAROS Investigators. Association between time taken to start dispatch assisted-bystander cardiopulmonary resuscitation (DA-CPR) and outcomes for out-of-hospital cardiac arrest (OHCA). Resuscitation. 2025 Aug;213:110651. doi: 10.1016/j.resuscitation.2025.110651. Epub 2025 May 21. PMID: 40409669.

33: Luo Y, Sze KP, Ng CJ, Ho AFW. World Family Doctor's Day reflection: how family medicine is building a sustainable healthcare system in Singapore. Singapore Med J. 2025 May 1;66(5):228-229. doi: 10.4103/singaporemedj.SMJ-2025-093. Epub 2025 May 19. PMID: 40384144; PMCID: PMC12161642.

34: Graves N, Böttger S, Zozmann M, Franziska M, Stocker R. Cost-effectiveness of adopting a postoperative delirium risk prediction tool with nonpharmacological delirium prevention interventions for surgical patients. AgeAgeing. 2025 May 3;54(5):afaf122. doi: 10.1093/ageing/afaf122. PMID: 40359905.

35: Tay JRH, Okada Y, Nadarajan GD, Siddiqui FJ, Barry T, Ong MEH. Pragmatic Risk Stratification Method to Identify Emergency Department Presentations for Alternative Care Service Pathways: Registry-Based Retrospective Study Over 5 Years. J Med Internet Res. 2025 May 12;27:e73758. doi: 10.2196/73758. PMID: 40354643; PMCID: PMC12107196.

36: Choa ZX, Raveentheran G, Khoo ZX, Ong GY, Wong L, Piragasam R, Ganapathy S, Chong SL. Prevalence of serious bacterial infections and performance of inflammatory markers in febrile infants with and without proven viral illness. Emerg Med J. 2025 Oct 20;42(11):721-727. doi: 10.1136/emermed-2024-214435. PMID: 40335269.

37: Pek PP, Chua M, Liew LX, Chen C, Lim SL, Uy FMR, Ho VK, Chia YW, Chua JM, Goh EL, Tham LP, Koh PL, Woo KL, Woo CTZ, Afiq IM, Fang K, Gan HN, Leong BS, Mao DR, Doctor NE, Ng WM, Oh YZ, Peck KH, Chen RW, Chia MY, Tay WL, Low SY, Li AY, Chong SL, Kang JM, Priyalatha S, Chia AQQ, Shahidah N, Ng BJH, Lee KY, Luo N, Ong MEH, Ho AFW. Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS). Resusc Plus. 2025 Mar 20;23:100938. doi: 10.1016/j.resplu.2025.100938. PMID: 40241994; PMCID: PMC12002988.

38: Ong JCL, Chen MH, Ng N, Elangovan K, Tan NYT, Jin L, Xie Q, Ting DSW, Rodriguez-Monguio R, Bates DW, Liu N. A scoping review on generative AI and large language models in mitigating medication related harm. NPJ Digit Med. 2025 Mar 28;8(1):182. doi: 10.1038/s41746-025-01565-7. PMID: 40155703; PMCID: PMC11953325.

39: Chong RJ, Hao Y, Tan EWQ, Mok GJL, Sia CH, Ho JSY, Chan MYY, Ho AFW. Prevalence of Depression, Anxiety and Post-Traumatic Stress Disorder (PTSD) After Acute Myocardial Infarction: A Systematic Review and Meta-Analysis. J Clin Med. 2025 Mar 7;14(6):1786. doi: 10.3390/jcm14061786. PMID: 40142595; PMCID: PMC11943088.

40: Fang K, Fook-Chong S, Okada Y, Siddiqui FJ, Shahidah N, Tanaka H, Shin SD, Ma MH, Kajino K, Lin CH, Kuo CW, Karim S, Jirapong S, Chen C, Ong MEH; PAROS Clinical Research Network CRN. Survival and neurological outcomes among OHCA patients in middle- and high-income countries in the Asia-Pacific. Resuscitation. 2025 Jun;211:110592. doi: 10.1016/j.resuscitation.2025.110592. Epub 2025 Mar 24. PMID: 40139425.

41: Chong SL, Zhu Y, Wang Q, Caporal P, Roa JD, Chamorro FIP, Teran Miranda TE, Dang H, Gan CS, Abbas Q, Ardila IJ, Antar MA, Domínguez-Rojas JA, Rodríguez MM, Watzlawik NZ, Gómez Arriola NE, Yock-Corrales A, Lasso-Palomino RE, Xiu MM, Ong JSM, Kurosawa H, Aparicio G, Liu C, Samransamruajkit R, Jaramillo-Bustamante JC, Anantasit N, Chor YK, Turina DM, Lee PC, Flores MF, Pilar Orive FJ, Ng Pei Wen J, González-Dambrauskas S, Lee JH; Pediatric Acute and Critical Care Medicine inAsia Network (PACCMAN) and the Red Colaborativa Pediátrica de Latinoamérica

(LARed). Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury. JAMA Netw Open. 2025 Mar 3;8(3):e250438. doi: 10.1001/jamanetworkopen.2025.0438. Erratum in: JAMA Netw Open. 2025 May 1;8(5):e2515833. doi: 10.1001/jamanetworkopen.2025.15833. PMID: 40067302; PMCID:PMC11897838.

42: Lim AM, Foo YY, Ko AXT, Oh SX, Aung KCY, Sherwood SA, Kavalloor NV, Tan RMR, Feng J, Tyebally A, Chong SL. Barriers and facilitators in the implementation of a child restraint system discharge programme in Singapore: a qualitative study. Inj Prev. 2025 Mar 7:ip-2024-045507. doi: 10.1136/ip-2024-045507. Epub ahead of print. PMID: 40054886.

43: Okada Y, Hong KJ, Lim SL, Hong D, Ng YY, Leong BSH, Song KJ, Park JH, Ro YS, Kitamura T, Nishiyama C, Matsuyama T, Kiguchi T, Nishioka N, Iwami T, Shin SD, Ong MEH, Siddiqui FJ. Corrigendum to "The "invisible ceiling" of bystander CPR in three Asian countries: Descriptive study of national OHCA registry" [Resuscitation 206 (2025) 110445]. Resuscitation. 2025 Apr;209:110555. doi: 10.1016/j.resuscitation.2025.110555. Epub 2025 Mar 4. Erratum for:Resuscitation. 2025 Jan;206:110445. doi: 10.1016/j.resuscitation.2024.110445. PMID: 40043342.

44: Liu Z, Mohammadi R, Saffari SE, Chua WLT, Ng M, Siddiqui FJ, Ong MEH. Critical revisits after discharge from the emergency department. Int J Emerg Med. 2025 Mar 3;18(1):41. doi: 10.1186/s12245-025-00847-x. PMID: 40033175; PMCID: PMC11874766.

45: Chen RW, Chia YW, Ho AFW. Enhancing post-resuscitation care to optimise neurological outcomes: a call to action. Singapore Med J. 2025 Feb 1;66(2):64-65. doi: 10.4103/singaporemedj.SMJ-2025-016. Epub 2025 Feb 17. PMID: 39961090; PMCID: PMC11906099.

46: Chong SL, Zhan SJ, Khoo ZX, Piragasam R, Wong L, Saffari SE, Lee JH, Ganapathy S, Ong GY. Evaluating C-Reactive Protein and Procalcitonin Discordance Among Febrile Infants at Risk of Serious Bacterial Infections. Acta Paediatr.2025 Jul;114(7):1576-1585. doi: 10.1111/apa.17602. Epub 2025 Jan 28. PMID: 39873924.

47: Nadarajan GD, Pek PP, Blewer AL, Haedar A, Staton C, Wong KD, Mesa-Gaerlan FJ, Karim S, Riyapan S, Østbye T, Ong MEH, Joiner A. Establishing Core Elements for a Prehospital Emergency Care Systems Evaluation Tool (PECSET) for Systems in Early Stages of Development: A Delphi Consensus. Prehosp Emerg Care. 2025;29(7):982-992. doi: 10.1080/10903127.2024.2443472. Epub 2025 Jan 13. PMID: 39700053.

48: Low XC, Lee JJ, Xie Y, Wong SMJ, Graves N. Economic evaluation of palliative gastrointestinal surgery for advanced cancer patients with malignant bowel obstruction: A systematic review. Eur J Surg Oncol. 2025 Feb;51(2):109490. doi: 10.1016/j.ejso.2024.109490. Epub 2024 Nov 23. PMID: 39667288.

49: Sia CH, Ho AFW. Cardiogenic shock in the setting of acute myocardial infarction: Still a difficult entity to treat. Int J Cardiol. 2025 Feb 15;421:132886. doi: 10.1016/j.ijcard.2024.132886. Epub 2024 Dec 7. PMID: 39647782.

50: Chua ZX, Yeh Lai Amanda C, Lam TJR, Ong JSP, Lim SYW, Kumar S, Lim MJR, Tan BYQ, Aik J, Ho AFW. Impact of smoke-free legislation on stroke risk: A systematic review and meta-analysis. Eur Stroke J. 2025 Jun;10(2):350-361. doi: 10.1177/23969873241293566. Epub 2024 Oct 30. PMID: 39475361; PMCID: PMC11556582.

51: Senanayake S, Kularatna S, Lee ASY, Lee A, Lau YH, Hausenloy DJ, Yeo KK, Chan MY, Wong RCC, Loh SY, Sim KLD, Weien C, Graves N. Health Services Costs of Clinical Heart Failure With Reduced Ejection Fraction in Singapore. Value Health Reg Issues. 2025 Jan;45:101037. doi: 10.1016/j.vhri.2024.101037. Epub 2024 Sep 2. Erratum in: Value Health Reg Issues. 2025 Nov;50:101502. doi: 10.1016/j.vhri.2025.101502. PMID: 39226724.

2024

Zhuang Q, Zhang AY, Cong R, Yang GM, Neo PSH, Tan DS, Chua ML, Tan IB, Wong FY, Eng Hock Ong M, Shao Wei Lam S, Liu N. Towards proactive palliative care in oncology: developing an explainable EHR-based machine learning model for mortality risk prediction. BMC Palliat Care. 2024;23(1):124. Epub 20240520. doi: 10.1186/s12904-024-01457-9. PubMed PMID: 38769564; PubMed Central PMCID: PMCPMC11103848.
Yuan H, Hong C, Tran NTA, Xu X, Liu N. Leveraging anatomical constraints with uncertainty for pneumothorax segmentation. Health Care Sci. 2024;3(6):456-74. Epub 20241215. doi: 10.1002/hcs2.119. PubMed PMID: 39735285; PubMed Central PMCID: PMCPMC11671217.
Yuan H, Hong C, Jiang PT, Zhao G, Tran NTA, Xu X, Yan YY, Liu N. Clinical domain knowledge-derived template improves post hoc AI explanations in pneumothorax classification. J Biomed Inform. 2024;156:104673. Epub 20240609. doi: 10.1016/j.jbi.2024.104673. PubMed PMID: 38862083.
Yock-Corrales A, Lee JH, Domínguez-Rojas J, Caporal P, Roa JD, Fernandez-Sarmiento J, González-Dambrauskas S, Zhu Y, Abbas Q, Kazzaz Y, Dewi DS, Chong SL. A Multicenter Study on the Clinical Characteristics and Outcomes Among Children With Moderate to Severe Abusive Head Trauma. J Pediatr Surg. 2024;59(3):494-9. Epub 20230930. doi: 10.1016/j.jpedsurg.2023.09.038. PubMed PMID: 37867044.
Yang R, Nair SV, Ke Y, D'Agostino D, Liu M, Ning Y, Liu N. Disparities in clinical studies of AI enabled applications from a global perspective. NPJ Digit Med. 2024;7(1):209. Epub 20240810. doi: 10.1038/s41746-024-01212-7. PubMed PMID: 39127820; PubMed Central PMCID: PMCPMC11316833.
Wong A, Lai P, Chong HH, Lien CTC, Graves N. The Clinical and Cost-Effectiveness of an Individualized Nutritional CAre (INCA) Bundle versus Standard Care for Adults with Pressure Injuries Receiving Home Nursing Services: A Protocol for a Cluster Randomized and Pragmatic Clinical Trial with an Economic Evaluation. Nutrients. 2024;16(2). Epub 20240118. doi: 10.3390/nu16020299. PubMed PMID: 38257192; PubMed Central PMCID: PMCPMC10819700.
Toh L, Lee JW, Ang SH, Ganapathy S, Nadarajan J, Chong SL. Evaluation of unplanned reattendances to the pediatric emergency department - a five-year study. BMC Pediatr. 2024;24(1):662. Epub 20241015. doi: 10.1186/s12887-024-05098-y. PubMed PMID: 39407164; PubMed Central PMCID: PMCPMC11475533.
Teo JN, Teo YT, Ganapathy S, Maiwald M, Ng YH, Chong SL. Investigating urinary characteristics and optimal urine white blood cell threshold in paediatric urinary tract infection: A prospective observational study. Ann Acad Med Singap. 2024;53(9):539-50. Epub 20240919. doi: 10.47102/annals-acadmedsg.202477. PubMed PMID: 39373373.
Sutiman N, Yao SHW, Goh SSM, Sultana R, Chong SL. Protocol for the diagnostic performance of C reactive protein, procalcitonin and interleukin-6 for serious bacterial infections among children ≤36 months old presenting with fever without source: a systematic review and meta-analysis. BMJ Paediatr Open. 2024;8(1). Epub 20240318. doi: 10.1136/bmjpo-2023-002237. PubMed PMID: 38499348; PubMed Central PMCID: PMCPMC10952928.
Siddiqui FJ, McNally B, Gräsner JT, Ho AFW, Tjelmeland I, Iwami T, Bray J, Wnent J, Lynn Lim S, Pin Pek P, Do Shin S, Ong MEH. Towards advancing Out-of-Hospital cardiac arrest (OHCA) registries globally: Considerations from the global OHCA registry (GOHCAR) collaborative. Resusc Plus. 2024;18:100615. Epub 20240322. doi: 10.1016/j.resplu.2024.100615. PubMed PMID: 38549697; PubMed Central PMCID: PMCPMC10973654.
Rajoo KP, Sutiman N, Shih S, Khoo ZX, Ong GY, Wong L, Piragasam R, Ganapathy S, Chong SL. Delayed presentation is associated with serious bacterial infections among febrile infants: A prospective cohort study. Ann Acad Med Singap. 2024;53(5):286-92. Epub 20240510. doi: 10.47102/annals-acadmedsg.2023350. PubMed PMID: 38920220.
Rahadian RE, Okada Y, Shahidah N, Hong D, Ng YY, Chia MYC, Gan HN, Leong BSH, Mao DR, Ng WM, Doctor NE, Ong MEH. Machine learning prediction of refractory ventricular fibrillation in out-of-hospital cardiac arrest using features available to EMS. Resusc Plus. 2024;18:100606. Epub 20240318. doi: 10.1016/j.resplu.2024.100606. PubMed PMID: 38533482; PubMed Central PMCID: PMCPMC10963854.
Ouyang Y, Lee HY, Leong FL, Tey HJ, Shih V, Lim EH, Graves N. Cost-minimization analysis comparing subcutaneous trastuzumab at home with intravenous trastuzumab for HER2-positive breast cancer in Singapore. Ther Adv Med Oncol. 2024;16:17588359241293381. Epub 20241110. doi: 10.1177/17588359241293381. PubMed PMID: 39529891; PubMed Central PMCID: PMCPMC11552043.
Ong WJ, Seng JJB, Yap B, He G, Moochhala NA, Ng CL, Ganguly R, Lee JH, Chong SL. Impact of neonatal sepsis on neurocognitive outcomes: a systematic review and meta-analysis. BMC Pediatr. 2024;24(1):505. Epub 20240807. doi: 10.1186/s12887-024-04977-8. PubMed PMID: 39112966; PubMed Central PMCID: PMCPMC11304789.
Ong CA, Nadarajan GD, Fook-Chong S, Shahidah N, Arulanandam S, Ng YY, Chia MY, Tiah L, Mao DR, Ng WM, Leong BS, Doctor N, Ong ME, Siddiqui FJ. Increasing neurologically intact survival after out-of-hospital cardiac arrest among elderly: Singapore Experience. Resusc Plus. 2024;17:100573. Epub 20240209. doi: 10.1016/j.resplu.2024.100573. PubMed PMID: 38370311; PubMed Central PMCID: PMCPMC10869923.
Okada Y, Hughes F, Ong MEH. We need better preparedness and emergency responses to heat waves. Cjem. 2024;26(2):73-4. doi: 10.1007/s43678-024-00648-w. PubMed PMID: 38329676.
Ning Y, Teixayavong S, Shang Y, Savulescu J, Nagaraj V, Miao D, Mertens M, Ting DSW, Ong JCL, Liu M, Cao J, Dunn M, Vaughan R, Ong MEH, Sung JJ, Topol EJ, Liu N. Generative artificial intelligence and ethical considerations in health care: a scoping review and ethics checklist. Lancet Digit Health. 2024;6(11):e848-e56. Epub 20240917. doi: 10.1016/s2589-7500(24)00143-2. PubMed PMID: 39294061; PubMed Central PMCID: PMCPMC11542614.
Ning Y, Liu X, Collins GS, Moons KGM, McCradden M, Ting DSW, Ong JCL, Goldstein BA, Wagner SK, Keane PA, Topol EJ, Liu N. An ethics assessment tool for artificial intelligence implementation in healthcare: CARE-AI. Nat Med. 2024;30(11):3038-9. doi: 10.1038/s41591-024-03310-1. PubMed PMID: 39424948.
Ning Y, Li S, Ng YY, Chia MYC, Gan HN, Tiah L, Mao DR, Ng WM, Leong BS, Doctor N, Ong MEH, Liu N. Variable importance analysis with interpretable machine learning for fair risk prediction. PLOS Digit Health. 2024;3(7):e0000542. Epub 20240712. doi: 10.1371/journal.pdig.0000542. PubMed PMID: 38995879; PubMed Central PMCID: PMCPMC11244764.
Nazeha N, Mao DR, Hong D, Shahidah N, Chua ISY, Ng YY, Leong BSH, Tiah L, Chia MYC, Ng WM, Doctor NE, Ong MEH, Graves N. Cost-effectiveness analysis of a 'Termination of Resuscitation' protocol for the management of out-of-hospital cardiac arrest. Resuscitation. 2024;202:110323. Epub 20240717. doi: 10.1016/j.resuscitation.2024.110323. PubMed PMID: 39029582.
Nadarajan GD, Rasappan K, Ng JSY, Junchen ML, Yoon S. Medical students' experience and learning outcomes of overseas community involvement project: a qualitative study. BMC Med Educ. 2024;24(1):854. Epub 20240808. doi: 10.1186/s12909-024-05560-6. PubMed PMID: 39118034; PubMed Central PMCID: PMCPMC11311946.
Nadarajan GD, Ong MEH. The frame of survival for cardiopulmonary resuscitation in lower-resource settings. Lancet Glob Health. 2024;12(3):e378-e9. doi: 10.1016/s2214-109x(24)00005-6. PubMed PMID: 38365410.
Nadarajan GD, Jalil N, White AE, Hock MOE, Venkataraman A. Development of prehospital emergency care in Singapore. Int J Emerg Med. 2024;17(1):11. Epub 20240122. doi: 10.1186/s12245-023-00582-1. PubMed PMID: 38254085; PubMed Central PMCID: PMCPMC10802030.
Mai G, Lee JH, Caporal P, Roa GJ, González-Dambrauskas S, Zhu Y, Yock-Corrales A, Abbas Q, Kazzaz Y, Dewi DS, Chong SL. Initial dysnatremia and clinical outcomes in pediatric traumatic brain injury: a multicenter observational study. Acta Neurochir (Wien). 2024;166(1):82. Epub 20240214. doi: 10.1007/s00701-024-05919-0. PubMed PMID: 38353785.
Low IJ, Ong ECI, Pek PPM, Quah LJJ, Chong SL, Lim JH, Boggs KM, Camargo CAJ, Anantharaman V, Ho AFW. 2021 NEDI-Singapore study: an updated inventory of emergency department characteristics. Singapore Med J. 2024. Epub 20241004. doi: 10.4103/singaporemedj.SMJ-2023-271. PubMed PMID: 39363514.
Liu Z, Ong MEH. The ECG: old test, new possibilities. Cjem. 2024;26(12):844-5. doi: 10.1007/s43678-024-00822-0. PubMed PMID: 39652297.
Liu M, Ning Y, Ke Y, Shang Y, Chakraborty B, Ong MEH, Vaughan R, Liu N. FAIM: Fairness-aware interpretable modeling for trustworthy machine learning in healthcare. Patterns (N Y). 2024;5(10):101059. Epub 20240912. doi: 10.1016/j.patter.2024.101059. PubMed PMID: 39569213; PubMed Central PMCID: PMCPMC11573921.
Lim SL, Chan SP, Shahidah N, Woo KL, Lam SSW, Leong BS, Lip GYH, Ong MEH. Validation of the NULL-EASE Score for Predicting Survival in a Multiethnic Asian Cohort of Out-of-Hospital Cardiac Arrest. J Am Heart Assoc. 2024;13(16):e034133. Epub 20240731. doi: 10.1161/jaha.123.034133. PubMed PMID: 39082401; PubMed Central PMCID: PMCPMC11963946.
Lim MJR, Zheng H, Zhang Z, Sia CH, Tan BY, Hock Ong ME, Nga VDW, Yeo TT, Ho AFW. Trends in hemorrhagic stroke incidence and mortality in a National Stroke Registry of a multi-ethnic Asian population. Eur Stroke J. 2024;9(1):189-99. Epub 20230929. doi: 10.1177/23969873231202392. PubMed PMID: 37776052; PubMed Central PMCID: PMCPMC10916808.
Liang KWH, Lee JH, Qadri SK, Nadarajan J, Caporal P, Roa GJ, González-Dambrauskas S, Abbas Q, Kazzaz Y, Chong SL. Differences in clinical outcomes and resource utilization in pediatric traumatic brain injury between countries of different sociodemographic indices. J Neurosurg Pediatr. 2024;33(5):461-8. Epub 20240216. doi: 10.3171/2024.1.Peds23306. PubMed PMID: 38364231.
Li S, Miao D, Wu Q, Hong C, D'Agostino D, Li X, Ning Y, Shang Y, Wang Z, Liu M, Fu H, Ong MEH, Haddadi H, Liu N. Federated Learning in Healthcare: A Benchmark Comparison of Engineering and Statistical Approaches for Structured Data Analysis. Health Data Sci. 2024;4:0196. Epub 20241204. doi: 10.34133/hds.0196. PubMed PMID: 39635226; PubMed Central PMCID: PMCPMC11615161.
Lee DYX, Yau CE, Pek MPP, Xu H, Lim DYZ, Earnest A, Ong MEH, Ho AFW. Socioeconomic disadvantage and long-term survival duration in out-of-hospital cardiac arrest patients: A population-based cohort study. Resusc Plus. 2024;18:100610. Epub 20240320. doi: 10.1016/j.resplu.2024.100610. PubMed PMID: 38524148; PubMed Central PMCID: PMCPMC10960127.
Lam TJR, Liu Z, Tan BY, Ng YY, Tan CK, Wong XY, Venketasubramanian N, Yeo LLL, Ho AFW, Ong MEH. Prehospital stroke care in Singapore. Singapore Med J. 2024. Epub 20240306. doi: 10.4103/singaporemedj.SMJ-2023-066. PubMed PMID: 38449072.
Koh JSK, Ng ZM, Feng JXY, Badron J, Chiang LW, Ang ASY, Chong SL. Caregiver reported long-term outcomes in children with major trauma and traumatic brain injuries: A single-centre retrospective study. Ann Acad Med Singap. 2024;53(1):15-22. Epub 20240130. doi: 10.47102/annals-acadmedsg.202387. PubMed PMID: 38920211.
Ke Y, Yang R, Liu N. Comparing Open-Access Database and Traditional Intensive Care Studies Using Machine Learning: Bibliometric Analysis Study. J Med Internet Res. 2024;26:e48330. Epub 20240417. doi: 10.2196/48330. PubMed PMID: 38630522; PubMed Central PMCID: PMCPMC11063894.
Ke Y, Yang R, Lie SA, Lim TXY, Ning Y, Li I, Abdullah HR, Ting DSW, Liu N. Mitigating Cognitive Biases in Clinical Decision-Making Through Multi-Agent Conversations Using Large Language Models: Simulation Study. J Med Internet Res. 2024;26:e59439. Epub 20241119. doi: 10.2196/59439. PubMed PMID: 39561363; PubMed Central PMCID: PMCPMC11615553.
Ho AFW, Zheng H, Ng ZHC, Pek PP, Ng BJH, Chin YH, Lam TJR, Østbye T, Tromp J, Ong MEH, Yeo JW. Incidence and Long-Term Outcomes of Acute Myocardial Infarction Among Survivors of Out-of-Hospital Cardiac Arrest. J Am Heart Assoc. 2024;13(1):e031716. Epub 20231229. doi: 10.1161/jaha.123.031716. PubMed PMID: 38156500; PubMed Central PMCID: PMCPMC10863809.
Ho AFW, Yau CE, Ho JS, Lim SH, Ibrahim I, Kuan WS, Ooi SBS, Chan MY, Sia CH, Mosterd A, Gijsberts CM, de Hoog VC, Bank IEM, Doevendans PA, de Kleijn DPV. Predictors of major adverse cardiac events among patients with chest pain and low HEART score in the emergency department. Int J Cardiol. 2024;395:131573. Epub 20231104. doi: 10.1016/j.ijcard.2023.131573. PubMed PMID: 37931658.
Ho AFW, Lee KY, Nur S, Fook SC, Pek PP, Tanaka H, Sang DS, Chow PI, Tan BY, Lim SL, Ma MH, Ryoo HW, Lin CH, Kuo CW, Kajino K, Ong MEH. Association between Conversion to Shockable Rhythms and Survival with Favorable Neurological Outcomes for Out-of-Hospital Cardiac Arrests. Prehosp Emerg Care. 2024;28(1):126-34. Epub 20230601. doi: 10.1080/10903127.2023.2212039. PubMed PMID: 37171870.
Chua ZX, Yeh Lai Amanda C, Lam TJR, Ong JSP, Lim SYW, Kumar S, Lim MJR, Tan BYQ, Aik J, Ho AFW. Impact of smoke-free legislation on stroke risk: A systematic review and meta-analysis. Eur Stroke J. 2024:23969873241293566. Epub 20241030. doi: 10.1177/23969873241293566. PubMed PMID: 39475361; PubMed Central PMCID: PMCPMC11556582.
Chong SL, Lee JH. The Interplay of Social Determinants of Health With Critical Illness in Pediatric Sepsis. Pediatr Crit Care Med. 2024;25(9):866-8. Epub 20240905. doi: 10.1097/pcc.0000000000003574. PubMed PMID: 39288435.
Chong SL, Ahmad Asnawi AW, Tengku Mohd TAM, Tan SM. Prediction of Viable CD34 Count in Harvested Product by Peripheral Blood Hematopoietic Progenitor Count of Automated Hematology Analyzer Undergoing Hematopoietic Stem Cell Transplantation. J Blood Med. 2024;15:387-94. Epub 20240822. doi: 10.2147/jbm.S460820. PubMed PMID: 39188941; PubMed Central PMCID: PMCPMC11346492.
Chen C, Lo CYZ, Ho MJC, Ng Y, Chan HCY, Wu WHK, Ong MEH, Siddiqui FJ. Global Sex Disparities in Bystander Cardiopulmonary Resuscitation After Out-of-Hospital Cardiac Arrest: A Scoping Review. J Am Heart Assoc. 2024;13(18):e035794. Epub 20240909. doi: 10.1161/jaha.124.035794. PubMed PMID: 39248262; PubMed Central PMCID: PMCPMC11935603.
Cai Y, Philip EC, Arora S, Sim JXY, Chow W, Nazeha N, Whiteley S, Tiang DC, Neo SL, Hong W, Venkatachalam I, Graves N. The attributable mortality, length of stay, and health care costs of methicillin-resistant Staphylococcus aureus infections in Singapore. IJID Reg. 2024;12:100427. Epub 20240821. doi: 10.1016/j.ijregi.2024.100427. PubMed PMID: 39281193; PubMed Central PMCID: PMCPMC11402250.
Bray JE, Ong MEH. Beyond numbers: The importance of detailing systems of care when reporting data on the emergency response systems for cardiac arrest. Resuscitation. 2024;195:110117. Epub 20240114. doi: 10.1016/j.resuscitation.2024.110117. PubMed PMID: 38220064.

2023

Yang R, Tan TF, Lu W, Thirunavukarasu AJ, Ting DSW, Liu N. Large language models in health care: Development, applications, and challenges. Health Care Sci. 2023;2(4):255-63. Epub 20230724. doi: 10.1002/hcs2.61. PubMed PMID: 38939520; PubMed Central PMCID: PMCPMC11080827.
Xie F, Ning Y, Liu M, Li S, Saffari SE, Yuan H, Volovici V, Ting DSW, Goldstein BA, Ong MEH, Vaughan R, Chakraborty B, Liu N. A universal AutoScore framework to develop interpretable scoring systems for predicting common types of clinical outcomes. STAR Protoc. 2023;4(2):102302. Epub 20230512. doi: 10.1016/j.xpro.2023.102302. PubMed PMID: 37178115; PubMed Central PMCID: PMCPMC10200969.
Tan YY, Chua ZX, Loo GH, Ong JSP, Lim JH, Siddiqui FJ, Graves N, Ho AFW. Risk of wound infection with use of sterile versus clean gloves in wound repair at the Emergency Department: A systematic review and meta-analysis. Injury. 2023;54(11):111020. Epub 20230909. doi: 10.1016/j.injury.2023.111020. PubMed PMID: 37713965.
Tan JZ, Zhang DZ, Sundararaghavan S, Ganapathy S, Choo JTL, Rajendram MF, Chong SL. Chest pain attendances to a Paediatric Emergency Department pre- and post-COVID-19 vaccination. Transl Pediatr. 2023;12(11):2010-9. Epub 20231121. doi: 10.21037/tp-23-230. PubMed PMID: 38130582; PubMed Central PMCID: PMCPMC10730957.
Tan HS, Zeng Y, Qi Y, Sultana R, Tan CW, Sia AT, Sng BL, Siddiqui FJ. Automated mandatory bolus versus basal infusion for maintenance of epidural analgesia in labour. Cochrane Database Syst Rev. 2023;6(6):Cd011344. Epub 20230605. doi: 10.1002/14651858.CD011344.pub3. PubMed PMID: 37276327; PubMed Central PMCID: PMCPMC10240562.
Siddiqui FJ, Fook-Chong S, Shahidah N, Tan CK, Poh JY, Ng WM, Quah D, Ng YY, Leong BS, Ong ME. Technology activated community first responders in Singapore: Real-world care delivery & outcome trends. Resusc Plus. 2023;16:100486. Epub 20231013. doi: 10.1016/j.resplu.2023.100486. PubMed PMID: 37859630; PubMed Central PMCID: PMCPMC10582741.
Rao KA, Th'ng FCS, Mak CCM, Neo HN, Ubeynarayana CU, Nanta Kumar RK, Mao DRH. Factors associated with mental health outcomes in emergency department healthcare workers on the frontlines of the COVID-19 pandemic. Singapore Med J. 2023;64(2):141-5. Epub 20210928. doi: 10.11622/smedj.2021122. PubMed PMID: 34581548; PubMed Central PMCID: PMCPMC10071840.
Qadri SK, Lee JH, Zhu Y, Caporal P, Roa GJ, González-Dambrauskas S, Yock-Corrales A, Abbas Q, Kazzaz Y, Shi L, Sri Dewi D, Chong SL. A multicenter observational study on outcomes of moderate and severe pediatric traumatic brain injuries-time to reappraise thresholds for treatment. Acta Neurochir (Wien). 2023;165(11):3197-206. Epub 20230920. doi: 10.1007/s00701-023-05741-0. PubMed PMID: 37728830.
Panja M, Chakraborty T, Kumar U, Liu N. Epicasting: An Ensemble Wavelet Neural Network for forecasting epidemics. Neural Netw. 2023;165:185-212. Epub 20230601. doi: 10.1016/j.neunet.2023.05.049. PubMed PMID: 37307664.
Ong MEH, Siddiqui FJ. Hidden disparities in the rising prevalence of bystander cardiopulmonary resuscitation. Nat Rev Cardiol. 2023;20(3):143-4. doi: 10.1038/s41569-022-00830-6. PubMed PMID: 36609603.
Okada Y, Shahidah N, Ng YY, Chia MYC, Gan HN, Leong BSH, Mao DR, Ng WM, Irisawa T, Yamada T, Nishimura T, Kiguchi T, Kishimoto M, Matsuyama T, Nishioka N, Kiyohara K, Kitamura T, Iwami T, Ong MEH. Outcome assessment for out-of-hospital cardiac arrest patients in Singapore and Japan with initial shockable rhythm. Crit Care. 2023;27(1):351. Epub 20230912. doi: 10.1186/s13054-023-04636-x. PubMed PMID: 37700335; PubMed Central PMCID: PMCPMC10496207.
Okada Y, Shahidah N, Ng YY, Chia MYC, Gan HN, Leong BSH, Mao DR, Ng WM, Edwin N, Kiguchi T, Nishioka N, Kitamura T, Iwami T, Ong MEH. Comparing outcomes of out-of-hospital cardiac arrest patients with initial shockable rhythm in Singapore and Osaka using population-based databases. Crit Care. 2023;27(1):479. Epub 20231206. doi: 10.1186/s13054-023-04771-5. PubMed PMID: 38057881; PubMed Central PMCID: PMCPMC10699037.
Okada Y, Ning Y, Ong MEH. Explainable artificial intelligence in emergency medicine: an overview. Clin Exp Emerg Med. 2023;10(4):354-62. Epub 20231128. doi: 10.15441/ceem.23.145. PubMed PMID: 38012816; PubMed Central PMCID: PMCPMC10790070.
Okada Y, Mertens M, Liu N, Lam SSW, Ong MEH. AI and machine learning in resuscitation: Ongoing research, new concepts, and key challenges. Resusc Plus. 2023;15:100435. Epub 20230728. doi: 10.1016/j.resplu.2023.100435. PubMed PMID: 37547540; PubMed Central PMCID: PMCPMC10400904.
Ng TP, Eng SW, Ting JXR, Bok C, Tay GYH, Kong SYJ, Stassen W, Zhang L, de Kleijn DPV, Ong MEH, Blewer AL, Yeo JW, Ho AFW. Global prevalence of basic life support training: A systematic review and meta-analysis. Resuscitation. 2023;186:109771. Epub 20230318. doi: 10.1016/j.resuscitation.2023.109771. PubMed PMID: 36934835.
Nazeha N, Meng L, Ho P, Ng YZ, Graves N. The burden of costs on health services by patients with neuro-ischaemic ulcers in Singapore. Int Wound J. 2023;20(3):669-77. Epub 20220810. doi: 10.1111/iwj.13908. PubMed PMID: 35948440; PubMed Central PMCID: PMCPMC9927887.
Nazeha N, Lee JY, Saffari SE, Meng L, Ho P, Ng YZ, Graves N. The burden of costs on health services from patients with venous leg ulcers in Singapore. Int Wound J. 2023;20(3):845-52. Epub 20220913. doi: 10.1111/iwj.13931. PubMed PMID: 36098383; PubMed Central PMCID: PMCPMC9927897.
Mai G, Lee JH, Caporal P, Roa GJ, González-Dambrauskas S, Zhu Y, Yock-Corrales A, Abbas Q, Kazzaz Y, Dewi DS, Chong SL. Prehospital and emergency management of pediatric traumatic brain injury: a multicenter site survey. J Neurosurg Pediatr. 2023;31(6):598-606. Epub 20230303. doi: 10.3171/2023.1.Peds22456. PubMed PMID: 38716719.
Lo JJ, Yoon S, Neo SHS, Sim DKL, Graves N. Elements of Potentially Inappropriate Interventions and Patient Prognostic Profiles at the End of Life in Cardiology: A Qualitative Analysis. J Palliat Med. 2023;26(5):700-3. Epub 20230214. doi: 10.1089/jpm.2022.0564. PubMed PMID: 36787484.
Lo JJ, Tromp J, Ouwerkwerk W, Ong MEH, Tan K, Sim D, Graves N. Examining predictors for 6-month mortality and healthcare utilization for patients admitted for heart failure in the acute care setting. Int J Cardiol. 2023;390:131237. Epub 20230801. doi: 10.1016/j.ijcard.2023.131237. PubMed PMID: 37536421.
Lo CYZ, Fook-Chong S, Shahidah N, White AE, Tan CK, Ng YY, Tiah L, Chia MYC, Leong BSH, Mao DR, Ng WM, Doctor NE, Ong MEH, Siddiqui FJ. Does witness type affect the chance of receiving bystander CPR in out-of-hospital cardiac arrest? Resuscitation. 2023;189:109873. Epub 20230614. doi: 10.1016/j.resuscitation.2023.109873. PubMed PMID: 37327852.
Liu M, Ning Y, Teixayavong S, Mertens M, Xu J, Ting DSW, Cheng LT, Ong JCL, Teo ZL, Tan TF, RaviChandran N, Wang F, Celi LA, Ong MEH, Liu N. A translational perspective towards clinical AI fairness. NPJ Digit Med. 2023;6(1):172. Epub 20230914. doi: 10.1038/s41746-023-00918-4. PubMed PMID: 37709945; PubMed Central PMCID: PMCPMC10502051.
Liu M, Li S, Yuan H, Ong MEH, Ning Y, Xie F, Saffari SE, Shang Y, Volovici V, Chakraborty B, Liu N. Handling missing values in healthcare data: A systematic review of deep learning-based imputation techniques. Artif Intell Med. 2023;142:102587. Epub 20230522. doi: 10.1016/j.artmed.2023.102587. PubMed PMID: 37316097.
Lim SL, Chan SP, Shahidah N, Ng QX, Ho AFW, Arulanandam S, Leong BS, Ong MEH. Temporal trends in out-of-hospital cardiac arrest with an initial non-shockable rhythm in Singapore. Resusc Plus. 2023;16:100473. Epub 20230913. doi: 10.1016/j.resplu.2023.100473. PubMed PMID: 37727148; PubMed Central PMCID: PMCPMC10506095.
Li S, Ning Y, Ong MEH, Chakraborty B, Hong C, Xie F, Yuan H, Liu M, Buckland DM, Chen Y, Liu N. FedScore: A privacy-preserving framework for federated scoring system development. J Biomed Inform. 2023;146:104485. Epub 20230901. doi: 10.1016/j.jbi.2023.104485. PubMed PMID: 37660960.
Li S, Liu P, Nascimento GG, Wang X, Leite FRM, Chakraborty B, Hong C, Ning Y, Xie F, Teo ZL, Ting DSW, Haddadi H, Ong MEH, Peres MA, Liu N. Federated and distributed learning applications for electronic health records and structured medical data: a scoping review. J Am Med Inform Assoc. 2023;30(12):2041-9. doi: 10.1093/jamia/ocad170. PubMed PMID: 37639629; PubMed Central PMCID: PMCPMC10654866.
Lee MHM, Chia MYC, Fook-Chong S, Shahidah N, Tagami T, Ryu HH, Lin CH, Karim SA, Jirapong S, Rao HVR, Cai W, Velasco BP, Khan NU, Son DN, Naroo GY, El Sayed M, Ong MEH. Characteristics and Outcomes of Traumatic Cardiac Arrests in the Pan-Asian Resuscitation Outcomes Study. Prehosp Emerg Care. 2023;27(8):978-86. Epub 20220906. doi: 10.1080/10903127.2022.2113941. PubMed PMID: 35994382.
Kumar A, Liu Z, Ansah JP, Ng YY, Leong BS-H, Matchar DB, Ong MEH, Siddiqui FJ. Viewing the Role of Alternate Care Service Pathways in the Emergency Care System through a Causal Loop Diagram Lens. Systems. 2023;11(5):215. PubMed PMID: doi:10.3390/systems11050215.
Koo GPY, Zheng H, Aik JCL, Tan BYQ, Sharma VK, Sia CH, Ong MEH, Ho AFW. Clustering of Environmental Parameters and the Risk of Acute Ischaemic Stroke. Int J Environ Res Public Health. 2023;20(6). Epub 20230311. doi: 10.3390/ijerph20064979. PubMed PMID: 36981888; PubMed Central PMCID: PMCPMC10049712.
Joiner A, Blewer AL, Pek PP, Ostbye T, Staton CA, Silvalila M, Ong M, Nadarajan GD. Barriers and facilitators for developing a prehospital emergency care system evaluation tool (PEC-SET) for low-resource settings: a qualitative analysis. BMJ Open. 2023;13(12):e077378. Epub 20231209. doi: 10.1136/bmjopen-2023-077378. PubMed PMID: 38070908; PubMed Central PMCID: PMCPMC10729032.
Ho AFW, Ting PZY, Ho JSY, Fook-Chong S, Shahidah N, Pek PP, Liu N, Teoh S, Sia CH, Lim DYZ, Lim SL, Wong TH, Ong MEH. The Effect of Building-Level Socioeconomic Status on Bystander Cardiopulmonary Resuscitation: A Retrospective Cohort Study. Prehosp Emerg Care. 2023;27(2):205-12. Epub 20220428. doi: 10.1080/10903127.2022.2061094. PubMed PMID: 35363103.
Ho AFW, Lim MJR, Earnest A, Blewer A, Graves N, Yeo JW, Pek PP, Tiah L, Ong MEH. Long term survival and disease burden from out-of-hospital cardiac arrest in Singapore: a population-based cohort study. Lancet Reg Health West Pac. 2023;32:100672. Epub 20221228. doi: 10.1016/j.lanwpc.2022.100672. PubMed PMID: 36785853; PubMed Central PMCID: PMCPMC9918801.
Graves N, Maiti R, Aloweni FAB, Yi Zhen N, Yuh AS, Bishnoi P, Chong TT, Carmody D, Harding K. Retrospective matched cohort study of incidence rates and excess length of hospital stay owing to pressure injuries in an Asian setting. Health Care Sci. 2023;2(2):82-93. Epub 20230313. doi: 10.1002/hcs2.30. PubMed PMID: 38938768; PubMed Central PMCID: PMCPMC11080845.
Graves N, Ganesan G, Tan KB, Goh OQ, Ho J, Chong TT, Bishnoi P, Carmody D, Yuh AS, Ng YZ, Lo Z, Enming Y, Abu Bakar Aloweni F, Zifei W, Harding K. Chronic wounds in a multiethnic Asian population: a cost of illness study. BMJ Open. 2023;13(9):e065692. Epub 20230918. doi: 10.1136/bmjopen-2022-065692. PubMed PMID: 37723106; PubMed Central PMCID: PMCPMC10510887.
Gräsner JT, Dicker B, Ho AFW. The value of resuscitation registries. Resusc Plus. 2023;15:100444. Epub 20230808. doi: 10.1016/j.resplu.2023.100444. PubMed PMID: 37583511; PubMed Central PMCID: PMCPMC10423697.
Goh OQM, Xin X, Lim WT, Tan MWJ, Kan JYL, Osman HB, Kee W, Teo TY, Tan WB, Kang ML, Graves N. Economic Evaluation of Novel Models of Care for Patients With Acute Medical Problems. JAMA Netw Open. 2023;6(9):e2334936. Epub 20230905. doi: 10.1001/jamanetworkopen.2023.34936. PubMed PMID: 37738050; PubMed Central PMCID: PMCPMC10517377.
Goh JL, Pek PP, Fook-Chong SMC, Ho AFW, Siddiqui FJ, Leong BS, Mao DRH, Ng W, Tiah L, Chia MY, Tham LP, Shahidah N, Arulanandam S, Ong MEH. Impact of time-to-compression on out-of-hospital cardiac arrest survival outcomes: A national registry study. Resuscitation. 2023;190:109917. Epub 20230726. doi: 10.1016/j.resuscitation.2023.109917. PubMed PMID: 37506813.
Chong SL, Niu C, Piragasam R, Koh ZX, Guo D, Lee JH, Ong GY, Ong MEH, Liu N. Adding heart rate n-variability (HRnV) to clinical assessment potentially improves prediction of serious bacterial infections in young febrile infants at the emergency department: a prospective observational study. Ann Transl Med. 2023;11(1):6. Epub 20221216. doi: 10.21037/atm-22-3303. PubMed PMID: 36760240; PubMed Central PMCID: PMCPMC9906196.
Chong SL, Niu C, Ong GY, Piragasam R, Khoo ZX, Koh ZX, Guo D, Lee JH, Ong MEH, Liu N. Febrile infants risk score at triage (FIRST) for the early identification of serious bacterial infections. Sci Rep. 2023;13(1):15845. Epub 20230922. doi: 10.1038/s41598-023-42854-z. PubMed PMID: 37740004; PubMed Central PMCID: PMCPMC10516995.
Chong SL, Leow EH, Yap CJY, Chao SM, Ganesan I, Ng YH. Risk factors for imaging abnormalities after the first febrile urinary tract infection in infants ≤3 months old: a retrospective cohort study. BMJ Paediatr Open. 2023;7(1). doi: 10.1136/bmjpo-2022-001687. PubMed PMID: 36649399; PubMed Central PMCID: PMCPMC9853243.
Chee ML, Chee ML, Huang H, Mazzochi K, Taylor K, Wang H, Feng M, Ho AFW, Siddiqui FJ, Ong MEH, Liu N. Artificial intelligence and machine learning in prehospital emergency care: A scoping review. iScience. 2023;26(8):107407. Epub 20230717. doi: 10.1016/j.isci.2023.107407. PubMed PMID: 37609632; PubMed Central PMCID: PMCPMC10440716.
Chan SL, Lee JW, Ong MEH, Siddiqui FJ, Graves N, Ho AFW, Liu N. Implementation of Prediction Models in the Emergency Department from an Implementation Science Perspective-Determinants, Outcomes, and Real-World Impact: A Scoping Review. Ann Emerg Med. 2023;82(1):22-36. Epub 20230314. doi: 10.1016/j.annemergmed.2023.02.001. PubMed PMID: 36925394.
Cai Y, Nazeha N, Perera S, Thiery AH, Girard MJA, Lee CE, Hong W, Graves N. A decision-support tool for funding health innovations at a tertiary academic medical center. Int J Technol Assess Health Care. 2023;39(1):e11. Epub 20230213. doi: 10.1017/s0266462323000028. PubMed PMID: 36779272; PubMed Central PMCID: PMCPMC11574547.
Cai Y, Chang K, Nazeha N, Gosavi TD, Shen JY, Hong W, Tan YL, Graves N. The cost-effectiveness of a real-time seizure detection application for people with epilepsy. Epilepsy Behav. 2023;148:109441. Epub 20230923. doi: 10.1016/j.yebeh.2023.109441. PubMed PMID: 37748415.

2022

Yau CE, Chen H, Lim BP, Ng M, Ponampalam R, Lim DYZ, Chin YH, Ho AFW. Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis. Clin Toxicol (Phila). 2023;61(1):1-11. Epub 20221129. doi: 10.1080/15563650.2022.2152350. PubMed PMID: 36444937.
Yuan H, Xie F, Ong MEH, Ning Y, Chee ML, Saffari SE, Abdullah HR, Goldstein BA, Chakraborty B, Liu N. AutoScore-Imbalance: An interpretable machine learning tool for development of clinical scores with rare events data. J Biomed Inform. 2022;129:104072. Epub 20220411. doi: 10.1016/j.jbi.2022.104072. PubMed PMID: 35421602.
Yoon S, Goh H, Chan A, Malhotra R, Visaria A, Matchar D, Lum E, Seng B, Ramakrishnan C, Quah S, Koh MS, Tiew PY, Bee YM, Abdullah H, Nadarajan GD, Graves N, Jafar T, Ong MEH. Spillover Effects of COVID-19 on Essential Chronic Care and Ways to Foster Health System Resilience to Support Vulnerable Non-COVID Patients: A Multistakeholder Study. J Am Med Dir Assoc. 2022;23(1):7-14. Epub 20211112. doi: 10.1016/j.jamda.2021.11.004. PubMed PMID: 34848198; PubMed Central PMCID: PMCPMC8585635.
Yeo JW, Ng ZHC, Goh AXC, Gao JF, Liu N, Lam SWS, Chia YW, Perkins GD, Ong MEH, Ho AFW. Impact of Cardiac Arrest Centers on the Survival of Patients With Nontraumatic Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2022;11(1):e023806. Epub 20211220. doi: 10.1161/jaha.121.023806. PubMed PMID: 34927456; PubMed Central PMCID: PMCPMC9075197.
Yaow CYL, Teoh SE, Lim WS, Wang RSQ, Han MX, Pek PP, Tan BY, Ong MEH, Ng QX, Ho AFW. Prevalence of anxiety, depression, and post-traumatic stress disorder after cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2022;170:82-91. Epub 20211123. doi: 10.1016/j.resuscitation.2021.11.023. PubMed PMID: 34826580.
Yang J, Ong WJ, Piragasam R, Allen JC, Lee JH, Chong SL. Delays in Time-To-Antibiotics for Young Febrile Infants With Serious Bacterial Infections: A Prospective Single-Center Study. Front Pediatr. 2022;10:873043. Epub 20220429. doi: 10.3389/fped.2022.873043. PubMed PMID: 35573970; PubMed Central PMCID: PMCPMC9099243.
Xie F, Zhou J, Lee JW, Tan M, Li S, Rajnthern LS, Chee ML, Chakraborty B, Wong AI, Dagan A, Ong MEH, Gao F, Liu N. Benchmarking emergency department prediction models with machine learning and public electronic health records. Sci Data. 2022;9(1):658. Epub 20221027. doi: 10.1038/s41597-022-01782-9. PubMed PMID: 36302776; PubMed Central PMCID: PMCPMC9610299.
Xie F, Yuan H, Ning Y, Ong MEH, Feng M, Hsu W, Chakraborty B, Liu N. Deep learning for temporal data representation in electronic health records: A systematic review of challenges and methodologies. J Biomed Inform. 2022;126:103980. Epub 20211230. doi: 10.1016/j.jbi.2021.103980. PubMed PMID: 34974189.
Xie F, Liu N, Yan L, Ning Y, Lim KK, Gong C, Kwan YH, Ho AFW, Low LL, Chakraborty B, Ong MEH. Development and validation of an interpretable machine learning scoring tool for estimating time to emergency readmissions. EClinicalMedicine. 2022;45:101315. Epub 20220306. doi: 10.1016/j.eclinm.2022.101315. PubMed PMID: 35284804; PubMed Central PMCID: PMCPMC8904223.
Wong XY, Ang YK, Li K, Chin YH, Lam SSW, Tan KBK, Chua MCH, Ong MEH, Liu N, Pourghaderi AR, Ho AFW. Development and validation of the SARICA score to predict survival after return of spontaneous circulation in out of hospital cardiac arrest using an interpretable machine learning framework. Resuscitation. 2022;170:126-33. Epub 20211126. doi: 10.1016/j.resuscitation.2021.11.029. PubMed PMID: 34843878.
Wong TH, Tan TXZ, Malhotra R, Nadkarni NV, Chua WC, Loo LM, Iau PTC, Ang ASH, Goo JTT, Chan KC, Matchar DB, Seow DCC, Nguyen HV, Ng YS, Chan A, Fook-Chong S, Tang TY, Ong MEH. Health Services Use and Functional Recovery Following Blunt Trauma in Older Persons - A National Multicentre Prospective Cohort Study. J Am Med Dir Assoc. 2022;23(4):646-53.e1. Epub 20211127. doi: 10.1016/j.jamda.2021.10.016. PubMed PMID: 34848197.
Weiting H, Yaoxian AZ, Keong YK, Lam SW, How LY, Sahlén AO, Pourghaderi A, Che M, Terrance CSJ, Graves N. The clinical value and cost-effectiveness of treatments for patients with coronary artery disease. Health Econ Rev. 2022;12(1):56. Epub 20221108. doi: 10.1186/s13561-022-00401-y. PubMed PMID: 36348165; PubMed Central PMCID: PMCPMC9644580.
Weiting H, Karthik G, Chua T, Graves N. Is a novel diagnostic pathway for cardiology outpatient clinics in Singapore lower cost than existing practice: a cost modelling study. BMJ Open. 2022;12(2):e050553. Epub 20220201. doi: 10.1136/bmjopen-2021-050553. PubMed PMID: 35105569; PubMed Central PMCID: PMCPMC8808421.
Volovici V, Syn NL, Ercole A, Zhao JJ, Liu N. Steps to avoid overuse and misuse of machine learning in clinical research. Nat Med. 2022;28(10):1996-9. doi: 10.1038/s41591-022-01961-6. PubMed PMID: 36097217.
Tham LP, Fook-Chong S, Binte Ahmad NS, Ong MEH. Reply to: Potential selection bias in the baseline. Resuscitation. 2022;178:127-9. Epub 20220709. doi: 10.1016/j.resuscitation.2022.07.002. PubMed PMID: 35820560.
Tham LP, Fook-Chong S, Binte Ahmad NS, Ho AF, Tanaka H, Shin SD, Ko PC, Wong KD, Jirapong S, Rao GVR, Cai W, Al Qahtani S, Ong MEH. Pre-hospital airway management and survival outcomes after paediatric out-of-hospital cardiac arrests. Resuscitation. 2022;176:9-18. Epub 20220426. doi: 10.1016/j.resuscitation.2022.04.018. PubMed PMID: 35483494.
Teo I, Nadarajan GD, Ng S, Bhaskar A, Sung SC, Cheung YB, Pan FT, Haedar A, Gaerlan FJ, Ong SF, Riyapan S, Do SN, Luong CQ, Rao V, Soh LM, Tan HK, Ong MEH. The Psychological Well-Being of Southeast Asian Frontline Healthcare Workers during COVID-19: A Multi-Country Study. Int J Environ Res Public Health. 2022;19(11). Epub 20220524. doi: 10.3390/ijerph19116380. PubMed PMID: 35681966; PubMed Central PMCID: PMCPMC9180104.
Tang XR, Zarisfi F, Pek PP, Siddiqui FJ, Malhotra R, Kwan YH, Ling T, Ho AFW, Ong MEH. Emergency department utilisation among older adults-Protocol for a systematic review of determinants and conceptual frameworks. PLoS One. 2022;17(6):e0265423. Epub 20220603. doi: 10.1371/journal.pone.0265423. PubMed PMID: 35661153; PubMed Central PMCID: PMCPMC9166351.
Tang XR, Pek PP, Siddiqui FJ, Malhotra R, Kwan YH, Tiah L, Ho AFW, Ong MEH. Determinants of emergency department utilisation by older adults in Singapore: A systematic review. Ann Acad Med Singap. 2022;51(3):170-9. doi: 10.47102/annals-acadmedsg.2021437. PubMed PMID: 35373240.
Tan YK, Han MX, Tan BY, Sia CH, Goh CXY, Leow AS, Hausenloy DJ, Chan ESY, Ong MEH, Ho AFW. The role of head-up cardiopulmonary resuscitation in sudden cardiac arrest: a systematic review and meta-analysis. Ann Transl Med. 2022;10(9):515. doi: 10.21037/atm-21-4984. PubMed PMID: 35928751; PubMed Central PMCID: PMCPMC9347036.
Tan VSR, Ong GY, Lee KP, Ganapathy S, Chong SL. Correction: Pyrexia in a young infant - is height of fever associated with serious bacterial infection? BMC Pediatr. 2022;22(1):343. Epub 20220615. doi: 10.1186/s12887-022-03374-3. PubMed PMID: 35705935; PubMed Central PMCID: PMCPMC9199123.
Tan VSR, Ong GY, Lee KP, Ganapathy S, Chong SL. Pyrexia in a young infant - is height of fever associated with serious bacterial infection? BMC Pediatr. 2022;22(1):188. Epub 20220408. doi: 10.1186/s12887-022-03264-8. PubMed PMID: 35395789; PubMed Central PMCID: PMCPMC8991795.
Tan RMR, Sherwood SA, Kavalloor NV, Feng JXY, Tyebally A, Chong SL. Child passenger safety training for healthcare professionals in Singapore. Ann Acad Med Singap. 2022;51(10):657-60. doi: 10.47102/annals-acadmedsg.2022169. PubMed PMID: 36317578.
Sutiman N, Khoo ZX, Ong GYK, Piragasam R, Chong SL. Validation and comparison of the PECARN rule, Step-by-Step approach and Lab-score for predicting serious and invasive bacterial infections in young febrile infants. Ann Acad Med Singap. 2022;51(10):595-604. doi: 10.47102/annals-acadmedsg.2022193. PubMed PMID: 36317570.
Sung SC, Lim L, Lim SH, Finkelstein EA, Chin SLH, Annathurai A, Chakraborty B, Strauman TJ, Pollack MH, Ong MEH. Protocol for a multi-site randomized controlled trial of a stepped-care intervention for emergency department patients with panic-related anxiety. BMC Psychiatry. 2022;22(1):795. Epub 20221216. doi: 10.1186/s12888-022-04387-z. PubMed PMID: 36527018; PubMed Central PMCID: PMCPMC9756520.
Soong JTY, Bell D, Ong MEH. Meeting today's healthcare needs: Medicine at the interface. Ann Acad Med Singap. 2022;51(12):787-92. doi: 10.47102/annals-acadmedsg.2022196. PubMed PMID: 36592147.
Saffari SE, Volovici V, Ong MEH, Goldstein BA, Vaughan R, Dammers R, Steyerberg EW, Liu N. Proper Use of Multiple Imputation and Dealing with Missing Covariate Data. World Neurosurg. 2022;161:284-90. doi: 10.1016/j.wneu.2021.10.090. PubMed PMID: 35505546.
Saffari SE, Ning Y, Xie F, Chakraborty B, Volovici V, Vaughan R, Ong MEH, Liu N. AutoScore-Ordinal: an interpretable machine learning framework for generating scoring models for ordinal outcomes. BMC Med Res Methodol. 2022;22(1):286. Epub 20221104. doi: 10.1186/s12874-022-01770-y. PubMed PMID: 36333672; PubMed Central PMCID: PMCPMC9636613.
Rajendram MF, Zarisfi F, Xie F, Shahidah N, Pek PP, Yeo JW, Tan BY, Ma M, Do Shin S, Tanaka H, Ong MEH, Liu N, Ho AFW. External validation of the Survival After ROSC in Cardiac Arrest (SARICA) score for predicting survival after return of spontaneous circulation using multinational pan-asian cohorts. Front Med (Lausanne). 2022;9:930226. Epub 20220908. doi: 10.3389/fmed.2022.930226. PubMed PMID: 36160129; PubMed Central PMCID: PMCPMC9492983.
Pek PP, Lau CY, Sim X, Tan KB, Mao DRH, Liu Z, Ho AF, Liu N, Ong MEH. Nationwide study of the characteristics of frequent attenders with multiple emergency department attendance patterns. Ann Acad Med Singap. 2022;51(8):483-92. doi: 10.47102/annals-acadmedsg.2021483. PubMed PMID: 36047523.
Ong MEH, Shin SD, Ko PC, Lin X, Ma MH, Ryoo HW, Wong KD, Supasaowapak J, Lin CH, Kuo CW, Rao R, Cai W, Gaerlan FJ, Khursheed M, Son DN, Sarah K, El Sayed M, Al Qahtani S, Tanaka H. International multi-center real world implementation trial to increase out-of-hospital cardiac arrest survival with a dispatcher-assisted cardio-pulmonary resuscitation package (Pan-Asian resuscitation outcomes study phase 2). Resuscitation. 2022;171:80-9. Epub 20211230. doi: 10.1016/j.resuscitation.2021.12.032. PubMed PMID: 34974143.
Ning Y, Ong MEH, Chakraborty B, Goldstein BA, Ting DSW, Vaughan R, Liu N. Shapley variable importance cloud for interpretable machine learning. Patterns (N Y). 2022;3(4):100452. Epub 20220222. doi: 10.1016/j.patter.2022.100452. PubMed PMID: 35465224; PubMed Central PMCID: PMCPMC9023900.
Ning Y, Li S, Ong MEH, Xie F, Chakraborty B, Ting DSW, Liu N. A novel interpretable machine learning system to generate clinical risk scores: An application for predicting early mortality or unplanned readmission in a retrospective cohort study. PLOS Digit Health. 2022;1(6):e0000062. Epub 20220613. doi: 10.1371/journal.pdig.0000062. PubMed PMID: 36812536; PubMed Central PMCID: PMCPMC9931273.
Ng ZHC, Ho SJ, Caleb T, Yaow CYL, Teoh SE, Tham LP, Ong MEH, Chong SL, Ho AFW. Long-Term Outcomes after Non-Traumatic Out-of-Hospital Cardiac Arrest in Pediatric Patients: A Systematic Review. J Clin Med. 2022;11(17). Epub 20220826. doi: 10.3390/jcm11175003. PubMed PMID: 36078931; PubMed Central PMCID: PMCPMC9457161.
Ng JYX, Sim ZJ, Siddiqui FJ, Shahidah N, Leong BS, Tiah L, Ng YY, Blewer A, Arulanandam S, Lim SL, Ong MEH, Ho AFW. Incidence, characteristics and complications of dispatcher-assisted cardiopulmonary resuscitation initiated in patients not in cardiac arrest. Resuscitation. 2022;170:266-73. Epub 20211006. doi: 10.1016/j.resuscitation.2021.09.022. PubMed PMID: 34626729.
Nazeha N, Koh AL, Kam S, Lim JY, Goh DLM, Jamuar SS, Graves N. Reduced resource utilization with early use of next-generation sequencing in rare genetic diseases in an Asian cohort. Am J Med Genet A. 2022;188(12):3482-91. Epub 20220925. doi: 10.1002/ajmg.a.62974. PubMed PMID: 36156406.
Masuda Y, Teoh SE, Yeo JW, Tan DJH, Jimian DL, Lim SL, Ong MEH, Blewer AL, Ho AFW. Variation in community and ambulance care processes for out-of-hospital cardiac arrest during the COVID-19 pandemic: a systematic review and meta-analysis. Sci Rep. 2022;12(1):800. Epub 20220117. doi: 10.1038/s41598-021-04749-9. PubMed PMID: 35039578; PubMed Central PMCID: PMCPMC8764072.
Lo JJ, Yoon S, Neo SHS, Sim DKL, Graves N. Factors Influencing Potentially Futile Treatments at the End of Life in a Multiethnic Asian Cardiology Setting: A Qualitative Study. Am J Hosp Palliat Care. 2022;39(9):1005-13. Epub 20211208. doi: 10.1177/10499091211053624. PubMed PMID: 34877875.
Liu Z, Mao DR, Fook-Chong S, Mak CCM, Tan XXE, Wu JT, Tan KB, Ong MEH, Siddiqui FJ. Nationwide Alcohol-related visits In Singapore's Emergency departments (NAISE): A retrospective population-level study from 2007 to 2016. Drug Alcohol Rev. 2022;41(5):1236-44. Epub 20220419. doi: 10.1111/dar.13472. PubMed PMID: 35437844.
Liu N, Xie F, Siddiqui FJ, Ho AFW, Chakraborty B, Nadarajan GD, Tan KBK, Ong MEH. Leveraging Large-Scale Electronic Health Records and Interpretable Machine Learning for Clinical Decision Making at the Emergency Department: Protocol for System Development and Validation. JMIR Res Protoc. 2022;11(3):e34201. Epub 20220325. doi: 10.2196/34201. PubMed PMID: 35333179; PubMed Central PMCID: PMCPMC9492092.
Liu N, Ning Y, Ong MEH, Saffari SE, Ryu HH, Kajino K, Lin CH, Karim SA, Rao GVR, Ho AFW, Lim SL, Siddiqui FJ. Gender disparities among adult recipients of layperson bystander cardiopulmonary resuscitation by location of cardiac arrest in Pan-Asian communities: A registry-based study. EClinicalMedicine. 2022;44:101293. Epub 20220212. doi: 10.1016/j.eclinm.2022.101293. PubMed PMID: 35198919; PubMed Central PMCID: PMCPMC8850341.
Liu N, Liu M, Chen X, Ning Y, Lee JW, Siddiqui FJ, Saffari SE, Ho AFW, Shin SD, Ma MH, Tanaka H, Ong MEH. Development and validation of an interpretable prehospital return of spontaneous circulation (P-ROSC) score for patients with out-of-hospital cardiac arrest using machine learning: A retrospective study. EClinicalMedicine. 2022;48:101422. Epub 20220506. doi: 10.1016/j.eclinm.2022.101422. PubMed PMID: 35706500; PubMed Central PMCID: PMCPMC9096672.
Limkakeng AT, Ye JJ, Staton C, Ng YY, Leong BSH, Shahidah N, Yazid M, Gordee A, Kuchibhatla M, Ong MEH. Impact of dispatcher-assisted cardiopulmonary resuscitation on performance of termination of resuscitation criteria. Resuscitation. 2022;170:160-6. Epub 20211203. doi: 10.1016/j.resuscitation.2021.11.034. PubMed PMID: 34871758; PubMed Central PMCID: PMCPMC9272777.
Lim SL, Kumar L, Saffari SE, Shahidah N, Al-Araji R, Ng QX, Ho AFW, Arulanandam S, Leong BS, Liu N, Siddiqui FJ, McNally B, Ong MEH. Management of Out-of-Hospital Cardiac Arrest during COVID-19: A Tale of Two Cities. J Clin Med. 2022;11(17). Epub 20220901. doi: 10.3390/jcm11175177. PubMed PMID: 36079106; PubMed Central PMCID: PMCPMC9457434.
Lim JCL, Loh N, Lam HH, Lee JW, Liu N, Yeo JW, Ho AFW. The Role of Drones in Out-of-Hospital Cardiac Arrest: A Scoping Review. J Clin Med. 2022;11(19). Epub 20220928. doi: 10.3390/jcm11195744. PubMed PMID: 36233610; PubMed Central PMCID: PMCPMC9572186.
Lee KY, So WZ, Ho JSY, Guo L, Shi L, Zhu Y, Tiah L, Ho AFW. Prevalence of intracranial hemorrhage amongst patients presenting with out-of-hospital cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2022;176:136-49. Epub 20220510. doi: 10.1016/j.resuscitation.2022.05.001. PubMed PMID: 35551955.
Lam TJR, Yang J, Poh JE, Ong MEH, Liu N, Yeo JW, Gräsner JT, Masuda Y, Ho AFW. Long term risk of recurrence among survivors of sudden cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2022;176:30-41. Epub 20220505. doi: 10.1016/j.resuscitation.2022.04.027. PubMed PMID: 35526728.
Lam SSW, Pourghaderi AR, Abdullah HR, Nguyen F, Siddiqui FJ, Ansah JP, Low JG, Matchar DB, Ong MEH. An Agile Systems Modeling Framework for Bed Resource Planning During COVID-19 Pandemic in Singapore. Front Public Health. 2022;10:714092. Epub 20220518. doi: 10.3389/fpubh.2022.714092. PubMed PMID: 35664119; PubMed Central PMCID: PMCPMC9157760.
Koo GPY, Zheng H, Pek PP, Hughes F, Lim SL, Yeo JW, Ong MEH, Ho AFW. Clustering of Environmental Parameters and the Risk of Acute Myocardial Infarction. Int J Environ Res Public Health. 2022;19(14). Epub 20220711. doi: 10.3390/ijerph19148476. PubMed PMID: 35886328; PubMed Central PMCID: PMCPMC9318360.
Jaffar JLY, Fook-Chong S, Shahidah N, Ho AFW, Ng YY, Arulanandam S, White A, Liew LX, Asyikin N, Leong BSH, Gan HN, Mao D, Chia MYC, Cheah SO, Ong MEH. Inter-hospital trends of post-resuscitation interventions and outcomes of out-of-hospital cardiac arrest in Singapore. Ann Acad Med Singap. 2022;51(6):341-50. doi: 10.47102/annals-acadmedsg.2021498. PubMed PMID: 35786754.
Ho AFW, Yeo JW, Ong MEH. Cardiac arrest centres: what, who, when, and where? Curr Opin Crit Care. 2022;28(3):262-9. doi: 10.1097/mcc.0000000000000934. PubMed PMID: 35653246.
Ho AFW, Tan BY, Zheng H, Leow AS, Pek PP, Liu N, Raju Y, Yeo LL, Sharma VK, Ong ME, Aik J. Association of air pollution with acute ischemic stroke risk in Singapore: a time-stratified case-crossover study. Int J Stroke. 2022;17(9):983-9. Epub 20220104. doi: 10.1177/17474930211066745. PubMed PMID: 35974459.
Ho AFW, Lim MJR, Zheng H, Leow AS, Tan BY, Pek PP, Raju Y, Seow WJ, Yeo TT, Sharma VK, Aik J, Ong MEH. Association of ambient air pollution with risk of hemorrhagic stroke: A time-stratified case crossover analysis of the Singapore stroke registry. Int J Hyg Environ Health. 2022;240:113908. Epub 20211230. doi: 10.1016/j.ijheh.2021.113908. PubMed PMID: 34974273.
Ho AFW, Hu Z, Woo TZC, Tan KBK, Lim JH, Woo M, Liu N, Morgan GG, Ong MEH, Aik J. Ambient Air Quality and Emergency Hospital Admissions in Singapore: A Time-Series Analysis. Int J Environ Res Public Health. 2022;19(20). Epub 20221016. doi: 10.3390/ijerph192013336. PubMed PMID: 36293917; PubMed Central PMCID: PMCPMC9603816.
Ho AFW, Ho JSY, Tan BY, Saffari SE, Yeo JW, Sia CH, Wang M, Aik J, Zheng H, Morgan G, Tam WWS, Seow WJ, Ong MEH. Air quality and the risk of out-of-hospital cardiac arrest in Singapore (PAROS): a time series analysis. Lancet Public Health. 2022;7(11):e932-e41. doi: 10.1016/s2468-2667(22)00234-1. PubMed PMID: 36334609.
Guerrero A, Blewer AL, Joiner AP, Leong BSH, Shahidah N, Pek PP, Ng YY, Arulanandam S, Østbye T, Gordee A, Kuchibhatla M, Ong MEH. Evaluation of telephone-assisted cardiopulmonary resuscitation recommendations for out-of-hospital cardiac arrest. Resuscitation. 2022;178:87-95. Epub 20220721. doi: 10.1016/j.resuscitation.2022.07.021. PubMed PMID: 35870555; PubMed Central PMCID: PMCPMC10013180.
Graves N, Kiernan M, Mitchell BG. A cost-effectiveness model for a decision to adopt temporary single-patient rooms to reduce risks of healthcare-associated infection in the Australian public healthcare system. Infect Dis Health. 2022;27(3):129-35. Epub 20220218. doi: 10.1016/j.idh.2022.01.004. PubMed PMID: 35190298.
Graves N, Flint J, Sagdeo A, Askari A, Ball P, Morrissey H. Spontaneous Pneumothorax in a Patient with Systemic Lupus Erythematosus and Recent Infection with Coronavirus. Case Rep Pulmonol. 2022;2022:9594063. Epub 20220822. doi: 10.1155/2022/9594063. PubMed PMID: 36046751; PubMed Central PMCID: PMCPMC9424047.
Graves N, Cai Y, Mitchell B, Fisher D, Kiernan M. Cost effectiveness of temporary isolation rooms in acute care settings in Singapore. PLoS One. 2022;17(7):e0271739. Epub 20220722. doi: 10.1371/journal.pone.0271739. PubMed PMID: 35867648; PubMed Central PMCID: PMCPMC9307192.
Gorden LYT, Ariel YF, Pei H, Meng L, Yi Zhen NG, Graves N. Decision-making for early major amputation in selected diabetic foot ulcer patients with peripheral vascular disease. Health Care Sci. 2022;1(2):58-68. Epub 20220919. doi: 10.1002/hcs2.17. PubMed PMID: 38938892; PubMed Central PMCID: PMCPMC11080880.
Goh AXC, Yeo JW, Gao JF, Ong MEH, Chong SL, Siddiqui FJ, Ho AFW. Comparative efficacy of anaesthetic methods for closed reduction of paediatric forearm fractures: a systematic review. Emerg Med J. 2022;39(12):888-96. Epub 20220217. doi: 10.1136/emermed-2021-212108. PubMed PMID: 35177437.
Goh AXC, Seow JC, Lai MYH, Liu N, Man Goh Y, Ong MEH, Lim SL, Ho JSY, Yeo JW, Ho AFW. Association of High-Volume Centers With Survival Outcomes Among Patients With Nontraumatic Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis. JAMA Netw Open. 2022;5(5):e2214639. Epub 20220502. doi: 10.1001/jamanetworkopen.2022.14639. PubMed PMID: 35639377; PubMed Central PMCID: PMCPMC9157264.
Goh AXC, Ho AFW. Correspondence: is there an association between centre volume and survival or neurological outcomes among out-of-hospital cardiac arrest patients? BMC Emerg Med. 2022;22(1):197. Epub 20221210. doi: 10.1186/s12873-022-00743-0. PubMed PMID: 36494626; PubMed Central PMCID: PMCPMC9737739.
Gan MY, Lee WL, Yap BJ, Seethor STT, Greenberg RG, Pek JH, Tan B, Hornik CPV, Lee JH, Chong SL. Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis. Front Pediatr. 2022;10:890767. Epub 20220603. doi: 10.3389/fped.2022.890767. PubMed PMID: 35722477; PubMed Central PMCID: PMCPMC9204066.
Chua ISY, Fook-Chong SMC, Shahidah N, Ng YY, Chia MYC, Mao DR, Leong BSH, Cheah SO, Gan HN, Doctor NE, Tham LP, Ong MEH. The association between mode of transport and out-of-hospital cardiac arrest outcomes in Singapore. Resuscitation. 2022;173:136-43. Epub 20220125. doi: 10.1016/j.resuscitation.2022.01.020. PubMed PMID: 35090972.
Choo KJL, Ho AFW, Gui H, Tay PJM, Lee HY, Koh MS, Earnest A, Pek PP, Liu N, Chong SL, Pang J, Ong MEH. Relationship between local weather, air pollution and hospital attendances for urticaria in children: Time stratified analysis of 12,002 cases. Clin Exp Allergy. 2022;52(1):180-2. Epub 20210928. doi: 10.1111/cea.14015. PubMed PMID: 34549849.
Chong SL, Tan JL, Ngeow YF. The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer. BMC Genomics. 2022;23(1):715. Epub 20221020. doi: 10.1186/s12864-022-08941-7. PubMed PMID: 36261788; PubMed Central PMCID: PMCPMC9583574.
Chong SL, Tan IS, Foo HCY, Chan YS, Lam MK, Lee KT. Ultrasonic‑assisted molten salt hydrates pretreated Eucheuma cottonii residues as a greener precursor for third-generation l-lactic acid production. Bioresour Technol. 2022;364:128136. Epub 20221015. doi: 10.1016/j.biortech.2022.128136. PubMed PMID: 36257523.
Chong SL, Quek SE, Lee JH. Moderate Pediatric Traumatic Brain Injury: What Is the Best Way Forward? Pediatr Crit Care Med. 2022;23(6):e300-e1. Epub 20220527. doi: 10.1097/pcc.0000000000002937. PubMed PMID: 35703781.
Chong SL, Qian S, Yao SHW, Allen JC, Dang H, Chan LCN, Ming M, Gan CS, Ong JSM, Kurosawa H, Lee JH. Early posttraumatic seizures in pediatric traumatic brain injury: a multicenter analysis. J Neurosurg Pediatr. 2022;29(2):225-31. Epub 20211029. doi: 10.3171/2021.8.Peds21281. PubMed PMID: 34715667.
Chong SL, Goh MSL, Ong GY, Acworth J, Sultana R, Yao SHW, Ng KC. Do paediatric early warning systems reduce mortality and critical deterioration events among children? A systematic review and meta-analysis. Resusc Plus. 2022;11:100262. Epub 20220629. doi: 10.1016/j.resplu.2022.100262. PubMed PMID: 35801231; PubMed Central PMCID: PMCPMC9253845.
Chin YH, Yaow CYL, Teoh SE, Foo MZQ, Luo N, Graves N, Ong MEH, Ho AFW. Long-term outcomes after out-of-hospital cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2022;171:15-29. Epub 20211229. doi: 10.1016/j.resuscitation.2021.12.026. PubMed PMID: 34971720.
Cher W, Quek SE, Badron J, Feng J, Ong GY, Lee KP, Chong SL. Risk Factors for Ankle Fractures in Asian Adolescents Seen in a Pediatric Emergency Department. Pediatr Emerg Care. 2022;38(12):672-7. Epub 20220124. doi: 10.1097/pec.0000000000002609. PubMed PMID: 36449737.
Chan SL, Lum E, Ong MEH, Graves N. Implementation science: A critical but undervalued part of the healthcare innovation ecosystem. Health Care Sci. 2022;1(3):160-5. Epub 20221012. doi: 10.1002/hcs2.22. PubMed PMID: 38938555; PubMed Central PMCID: PMCPMC11080739.
Chan SL, Lee JW, Ong MEH, Siddiqui FJ, Graves N, Ho AFW, Liu N. Implementation of prediction models in the emergency department from an implementation science perspective-Determinants, outcomes and real-world impact: A scoping review protocol. PLoS One. 2022;17(5):e0267965. Epub 20220512. doi: 10.1371/journal.pone.0267965. PubMed PMID: 35551537; PubMed Central PMCID: PMCPMC9097992.
Chan JJ, Goh ZX, Koh ZX, Soo JJE, Fergus J, Ng YY, Allen JC, Jr., Ong MEH. Clinical evaluation of the use of laryngeal tube versus laryngeal mask airway for out-of-hospital cardiac arrest by paramedics in Singapore. Singapore Med J. 2022;63(3):157-61. Epub 20200817. doi: 10.11622/smedj.2020119. PubMed PMID: 32798357; PubMed Central PMCID: PMCPMC9251251.
Brooks SC, Clegg GR, Bray J, Deakin CD, Perkins GD, Ringh M, Smith CM, Link MS, Merchant RM, Pezo-Morales J, Parr M, Morrison LJ, Wang TL, Koster RW, Ong MEH. Optimizing Outcomes After Out-of-Hospital Cardiac Arrest With Innovative Approaches to Public-Access Defibrillation: A Scientific Statement From the International Liaison Committee on Resuscitation. Circulation. 2022;145(13):e776-e801. Epub 20220215. doi: 10.1161/cir.0000000000001013. PubMed PMID: 35164535.
Brooks SC, Clegg GR, Bray J, Deakin CD, Perkins GD, Ringh M, Smith CM, Link MS, Merchant RM, Pezo-Morales J, Parr M, Morrison LJ, Wang TL, Koster RW, Ong MEH. Optimizing outcomes after out-of-hospital cardiac arrest with innovative approaches to public-access defibrillation: A scientific statement from the International Liaison Committee on Resuscitation. Resuscitation. 2022;172:204-28. Epub 20220215. doi: 10.1016/j.resuscitation.2021.11.032. PubMed PMID: 35181376.
Blewer AL, Ho AFW. Community-level socioeconomic status and the role of the hospital: Does where you have an arrest affect receipt of post-arrest care? Resuscitation. 2022;176:27-9. Epub 20220511. doi: 10.1016/j.resuscitation.2022.05.003. PubMed PMID: 35568102.
Ang Y, Li S, Ong MEH, Xie F, Teo SH, Choong L, Koniman R, Chakraborty B, Ho AFW, Liu N. Development and validation of an interpretable clinical score for early identification of acute kidney injury at the emergency department. Sci Rep. 2022;12(1):7111. Epub 20220502. doi: 10.1038/s41598-022-11129-4. PubMed PMID: 35501411; PubMed Central PMCID: PMCPMC9061747.

2021

Cai Y, Venkatachalam I, Kwa AL, Tambyah PA, Hsu LY, Marimuthu K, Graves N. Estimating the excess bed days and economic burden of healthcare-associated infections in Singapore public acute-care hospitals. Infect Control Hosp Epidemiol. 2022;43(9):1245-8. Epub 20210521. doi: 10.1017/ice.2021.165. PubMed PMID: 34016198.
Wong XY, Fan Q, Shahidah N, De Souza CR, Arulanandam S, Ng YY, Ng WM, Leong BSH, Chia MYC, Ong MEH. Impact of dispatcher-assisted cardiopulmonary resuscitation and myResponder mobile app on bystander resuscitation. Ann Acad Med Singap. 2021;50(3):212-21. doi: 10.47102/annals-acadmedsg.2020458. PubMed PMID: 33855317.
Wee CPJ, He DX, Win W, Ong MEH. Geospatial analysis of severe road traffic accidents in Singapore in 2013-2014. Singapore Med J. 2021;62(7):353-8. Epub 20200325. doi: 10.11622/smedj.2020037. PubMed PMID: 32211912; PubMed Central PMCID: PMCPMC8801850.
Tong WY, Tan SW, Chong SL. Epidemiology and risk stratification of minor head injuries in school-going children. Ann Acad Med Singap. 2021;50(2):119-25. doi: 10.47102/annals-acadmedsg.2020274. PubMed PMID: 33733254.
Teoh SE, Masuda Y, Tan DJH, Liu N, Morrison LJ, Ong MEH, Blewer AL, Ho AFW. Impact of the COVID-19 pandemic on the epidemiology of out-of-hospital cardiac arrest: a systematic review and meta-analysis. Ann Intensive Care. 2021;11(1):169. Epub 20211207. doi: 10.1186/s13613-021-00957-8. PubMed PMID: 34874498; PubMed Central PMCID: PMCPMC8649312.
Tan HY, Mao DRH. Community-level interventions for out-of-hospital cardiac arrests in Singapore: Yay or nay? Ann Acad Med Singap. 2021;50(3):200-2. doi: 10.47102/annals-acadmedsg.2021106. PubMed PMID: 33855315.
Tan BKK, Chin YX, Koh ZX, Md Said N, Rahmat M, Fook-Chong S, Ng YY, Ong MEH. Clinical evaluation of intravenous alone versus intravenous or intraosseous access for treatment of out-of-hospital cardiac arrest. Resuscitation. 2021;159:129-36. Epub 20201119. doi: 10.1016/j.resuscitation.2020.11.019. PubMed PMID: 33221362.
Page K, Graves N. A cross sectional study of organizational factors and their impact on job satisfaction and emotional burnout in a group of Australian nurses: infection control practitioners. BMC Health Serv Res. 2021;21(1):441. Epub 20210510. doi: 10.1186/s12913-021-06477-2. PubMed PMID: 33971860; PubMed Central PMCID: PMCPMC8108460.
Nazeha N, Ong MEH, Limkakeng AT, Jr., Ye JJ, Joiner AP, Blewer A, Shahidah N, Nadarajan GD, Mao DR, Graves N. A hypothetical implementation of 'Termination of Resuscitation' protocol for out-of-hospital cardiac arrest. Resusc Plus. 2021;6:100092. Epub 20210303. doi: 10.1016/j.resplu.2021.100092. PubMed PMID: 34223357; PubMed Central PMCID: PMCPMC8244430.
Nadarajan GD, Rao GR, Reddy K, Gimkala A, Janumpally R, Ang Y, Woo CTZ, Neo TH, Wong XY, Ong MEH. Characteristics of Prehospital Heat Illness Cases During the Annual Heat Wave Period in Telangana, India. Prehosp Disaster Med. 2021;36(4):385-92. Epub 20210709. doi: 10.1017/s1049023x21000583. PubMed PMID: 34238399.
Ming Ng W, De Souza CR, Pek PP, Shahidah N, Ng YY, Arulanandam S, White AE, Leong BS, Ong MEH. myResponder Smartphone Application to Crowdsource Basic Life Support for Out-of-Hospital Cardiac Arrest: The Singapore Experience. Prehosp Emerg Care. 2021;25(3):388-96. Epub 20200709. doi: 10.1080/10903127.2020.1777233. PubMed PMID: 32497484.
Martin E, Beckmann M, Blythe R, Merollini K, Graves N. Adherence to best practice: Preventing surgical site infection following caesarean section in Australia. Aust N Z J Obstet Gynaecol. 2021;61(5):728-34. Epub 20210411. doi: 10.1111/ajo.13347. PubMed PMID: 33843068.
Liu Z, Lim MJ, Pek PP, Wong ASL, Tan KBK, Yeo KK, Ong MEH. Improved door-to-balloon time for primary percutaneous coronary intervention for patients conveyed via emergency ambulance service. Ann Acad Med Singap. 2021;50(9):671-8. doi: 10.47102/annals-acadmedsg.2021153. PubMed PMID: 34625754.
Liu N, Chee ML, Koh ZX, Leow SL, Ho AFW, Guo D, Ong MEH. Utilizing machine learning dimensionality reduction for risk stratification of chest pain patients in the emergency department. BMC Med Res Methodol. 2021;21(1):74. Epub 20210417. doi: 10.1186/s12874-021-01265-2. PubMed PMID: 33865317; PubMed Central PMCID: PMCPMC8052947.
Liu N, Chee ML, Foo MZQ, Pong JZ, Guo D, Koh ZX, Ho AFW, Niu C, Chong SL, Ong MEH. Heart rate n-variability (HRnV) measures for prediction of mortality in sepsis patients presenting at the emergency department. PLoS One. 2021;16(8):e0249868. Epub 20210830. doi: 10.1371/journal.pone.0249868. PubMed PMID: 34460853; PubMed Central PMCID: PMCPMC8405012.
Lim SL, Shahidah N, Saffari SE, Ng QX, Ho AFW, Leong BS, Arulanandam S, Siddiqui FJ, Ong MEH. Impact of COVID-19 on Out-of-Hospital Cardiac Arrest in Singapore. Int J Environ Res Public Health. 2021;18(7). Epub 20210331. doi: 10.3390/ijerph18073646. PubMed PMID: 33807454; PubMed Central PMCID: PMCPMC8036681.
Lim SL, Lau YH, Chan MY, Chua T, Tan HC, Foo D, Lim ZY, Liew BW, Shahidah N, Mao DR, Cheah SO, Chia MYC, Gan HN, Leong BSH, Ng YY, Yeo KK, Ong MEH. Early Coronary Angiography Is Associated with Improved 30-Day Outcomes among Patients with Out-of-Hospital Cardiac Arrest. J Clin Med. 2021;10(21). Epub 20211106. doi: 10.3390/jcm10215191. PubMed PMID: 34768711; PubMed Central PMCID: PMCPMC8584598.
Lim SH, Ng KC, Ching CK, Ong GY, Chia YW, Biswas A, Oh JHH, Lim JH, Zarisfi F, Loke JH, Leong BS. SRFAC: resuscitation and saving lives in the COVID-19 era and beyond. Singapore Med J. 2021;62(8):369-71. doi: 10.11622/smedj.2021106. PubMed PMID: 35001110; PubMed Central PMCID: PMCPMC8804488.
Lim SH, Chee TS, Wee FC, Tan SH, Loke JH, Leong BS. Singapore Basic Cardiac Life Support and Automated External Defibrillation Guidelines 2021. Singapore Med J. 2021;62(8):415-23. doi: 10.11622/smedj.2021108. PubMed PMID: 35001107; PubMed Central PMCID: PMCPMC8804482.
Lim KJ, Koh ZX, Ng YY, Fook-Chong S, Ho AFW, Doctor NE, Said N, Ong MEH. Comparison of inhalational methoxyflurane (Penthrox®) and intramuscular tramadol for prehospital analgesia. Singapore Med J. 2021;62(6):281-6. Epub 20200317. doi: 10.11622/smedj.2020035. PubMed PMID: 32179922; PubMed Central PMCID: PMCPMC8801836.
Lim DYZ, Wong TH, Feng M, Ong MEH, Ho AFW. Leveraging open data to reconstruct the Singapore Housing Index and other building-level markers of socioeconomic status for health services research. Int J Equity Health. 2021;20(1):218. Epub 20211003. doi: 10.1186/s12939-021-01554-8. PubMed PMID: 34602083; PubMed Central PMCID: PMCPMC8489093.
Leong PWK, Leong BS, Arulanandam S, Ng MXR, Ng YY, Ong MEH, Mao DRH. Simplified instructional phrasing in dispatcher-assisted cardiopulmonary resuscitation - when 'less is more'. Singapore Med J. 2021;62(12):647-52. Epub 20200527. doi: 10.11622/smedj.2020080. PubMed PMID: 32460451; PubMed Central PMCID: PMCPMC8804432.
Jones S, White N, Holt T, Graves N. Cost-effectiveness analysis of hydrogel spacer for rectal toxicity reduction in prostate external beam radiotherapy. J Med Imaging Radiat Oncol. 2021;65(7):931-9. Epub 20210816. doi: 10.1111/1754-9485.13311. PubMed PMID: 34397158.
Jadambaa A, Brain D, Pacella R, Thomas HJ, McCarthy M, Scott JG, Graves N. The Economic Cost of Child and Adolescent Bullying in Australia. J Am Acad Child Adolesc Psychiatry. 2021;60(3):367-76. Epub 20200630. doi: 10.1016/j.jaac.2020.05.010. PubMed PMID: 32619590.
Hu Z, Siddiqui FJ, Fan Q, Lian SWQ, Liu N, Ong MEH. Trends of chronic illness in emergency department admissions among elderly adults in a tertiary hospital over ten years. BMC Health Serv Res. 2021;21(1):1305. Epub 20211204. doi: 10.1186/s12913-021-07309-z. PubMed PMID: 34863159; PubMed Central PMCID: PMCPMC8645127.
Ho AFW, Tan TXZ, Latiff E, Shahidah N, Ng YY, Leong BS, Lim SL, Pek PP, Gan HN, Mao DR, Chia MYC, Cheah SO, Tham LP, Ong MEH. Assessing unrealised potential for organ donation after out-of-hospital cardiac arrest. Scand J Trauma Resusc Emerg Med. 2021;29(1):105. Epub 20210728. doi: 10.1186/s13049-021-00924-z. PubMed PMID: 34321054; PubMed Central PMCID: PMCPMC8317313.
Ho AFW, Pourghaderi AR, Ong MEH. Drone-delivered automated external defibrillators: How to site them? Resuscitation. 2021;163:189-90. Epub 20210424. doi: 10.1016/j.resuscitation.2021.04.011. PubMed PMID: 33901589.
Ho AFW, Ong MEH. Transportation during and after cardiac arrest: who, when, how and where? Curr Opin Crit Care. 2021;27(3):223-31. doi: 10.1097/mcc.0000000000000816. PubMed PMID: 33769418.
Goh MSL, Looi DSH, Goh JL, Sultana R, Goh SSM, Lee JH, Chong SL. The Impact of Traumatic Brain Injury on Neurocognitive Outcomes in Children: a Systematic Review and Meta-Analysis. J Neurol Neurosurg Psychiatry. 2021. Epub 20210331. doi: 10.1136/jnnp-2020-325066. PubMed PMID: 33789922.
Chong SL, Ong GY, Zheng CQ, Dang H, Ming M, Mahmood M, Chan LCN, Chuah SL, Lee OPE, Qian S, Fan L, Konoike Y, Lee JH. Early Coagulopathy in Pediatric Traumatic Brain Injury: A Pediatric Acute and Critical Care Medicine Asian Network (PACCMAN) Retrospective Study. Neurosurgery. 2021;89(2):283-90. doi: 10.1093/neuros/nyab157. PubMed PMID: 33913493.
Chong SL, Ong GY, Allen JC, Lee JH, Piragasam R, Koh GZX, Mahajan P, Liu N, Ong MEH. Early prediction of serious infections in febrile infants incorporating heart rate variability in an emergency department: a pilot study. Emerg Med J. 2021;38(8):607-12. Epub 20210416. doi: 10.1136/emermed-2020-210675. PubMed PMID: 33863774.
Chong SL, Dang H, Ming M, Mahmood M, Zheng CQS, Gan CS, Lee OPE, Ji J, Chan LCN, Ong JSM, Kurosawa H, Lee JH. Traumatic Brain Injury Outcomes in 10 Asian Pediatric ICUs: A Pediatric Acute and Critical Care Medicine Asian Network Retrospective Study. Pediatr Crit Care Med. 2021;22(4):401-11. doi: 10.1097/pcc.0000000000002575. PubMed PMID: 33027240.
Chong SL, Asnawi AWA, Leong TS, Tan JT, Law KB, Hon SL, Fann RJ, Tan SM. Impact of timely BCR-ABL1 monitoring before allogeneic stem cell transplantation among patients with BCR-ABL1-positive B-acute lymphoblastic leukemia. Blood Res. 2021;56(3):175-83. doi: 10.5045/br.2021.2021045. PubMed PMID: 34462403; PubMed Central PMCID: PMCPMC8478615.
Chong SL, Ahmad Asnawi AW, Hamzah R, Liew PK, Ong TC, Tan SM, Chang KM. Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura. Case Rep Oncol. 2021;14(3):1814-20. Epub 20211227. doi: 10.1159/000521159. PubMed PMID: 35111014; PubMed Central PMCID: PMCPMC8787534.
Chia YW, Lim SL, Loh JK, Leong BS, Ong MEH. Beyond return of spontaneous circulation: update on post-cardiac arrest management in the intensive care unit. Singapore Med J. 2021;62(8):444-51. doi: 10.11622/smedj.2021115. PubMed PMID: 35001117; PubMed Central PMCID: PMCPMC8804480.
Chee ML, Ong MEH, Siddiqui FJ, Zhang Z, Lim SL, Ho AFW, Liu N. Artificial Intelligence Applications for COVID-19 in Intensive Care and Emergency Settings: A Systematic Review. Int J Environ Res Public Health. 2021;18(9). Epub 20210429. doi: 10.3390/ijerph18094749. PubMed PMID: 33947006; PubMed Central PMCID: PMCPMC8125462.
Chang SSY, Lim AZ, Ong GY, Piragasam R, Allen JC, Ng KC, Maconochie I, Chong SL. Predictors of serious bacterial infections using serum biomarkers in an infant population aged 0 to 90 days: a prospective cohort study. BMJ Paediatr Open. 2021;5(1):e000861. Epub 20210120. doi: 10.1136/bmjpo-2020-000861. PubMed PMID: 34192187; PubMed Central PMCID: PMCPMC7818843.
Chan JSE, Chia DWJ, Hao Y, Lian SWQ, Chua MT, Ong MEH. Health-seeking behaviour of foreign workers in Singapore: Insights from emergency department visits. Ann Acad Med Singap. 2021;50(4):315-24. doi: 10.47102/annals-acadmedsg.2020484. PubMed PMID: 33990819.
Ansah JP, Matchar DB, Shao Wei SL, Low JG, Pourghaderi AR, Siddiqui FJ, Min TLS, Wei-Yan AC, Ong MEH. The effectiveness of public health interventions against COVID-19: Lessons from the Singapore experience. PLoS One. 2021;16(3):e0248742. Epub 20210330. doi: 10.1371/journal.pone.0248742. PubMed PMID: 33784332; PubMed Central PMCID: PMCPMC8009429.
Abdullah HR, Lam SSW, Ang BY, Pourghaderi A, Nguyen F, Matchar DB, Tan HK, Ong MEH. Resuming elective surgery after COVID-19: A simulation modelling framework for guiding the phased opening of operating rooms. Int J Med Inform. 2021;158:104665. Epub 20211214. doi: 10.1016/j.ijmedinf.2021.104665. PubMed PMID: 34923449; PubMed Central PMCID: PMCPMC8674476.

2020

Pek PP, Lim JYY, Leong BS, Mao DR, Chia MY, Cheah SO, Gan HN, Ng YY, Tham LP, Arulanandam S, Shahidah N, Lin X, Ho AFW, Ong MEH. Improved Out-of-Hospital Cardiac Arrest Survival with a Comprehensive Dispatcher-Assisted CPR Program in a Developing Emergency Care System. Prehosp Emerg Care. 2021;25(6):802-11. Epub 20201204. doi: 10.1080/10903127.2020.1846824. PubMed PMID: 33151108.
Zhang Z, Zheng B, Liu N. Individualized fluid administration for critically ill patients with sepsis with an interpretable dynamic treatment regimen model. Sci Rep. 2020;10(1):17874. Epub 20201021. doi: 10.1038/s41598-020-74906-z. PubMed PMID: 33087760; PubMed Central PMCID: PMCPMC7578643.
Yeo CFC, Li H, Koh ZX, Liu N, Ong MEH. Risk stratification of patients with atrial fibrillation in the emergency department. Am J Emerg Med. 2020;38(9):1807-15. Epub 20200611. doi: 10.1016/j.ajem.2020.06.018. PubMed PMID: 32738474.
Xie F, Chakraborty B, Ong MEH, Goldstein BA, Liu N. AutoScore: A Machine Learning-Based Automatic Clinical Score Generator and Its Application to Mortality Prediction Using Electronic Health Records. JMIR Med Inform. 2020;8(10):e21798. Epub 20201021. doi: 10.2196/21798. PubMed PMID: 33084589; PubMed Central PMCID: PMCPMC7641783.
White NM, Barnett AG, Hall L, Mitchell BG, Farrington A, Halton K, Paterson DL, Riley TV, Gardner A, Page K, Gericke CA, Graves N. Cost-effectiveness of an Environmental Cleaning Bundle for Reducing Healthcare-associated Infections. Clin Infect Dis. 2020;70(12):2461-8. doi: 10.1093/cid/ciz717. PubMed PMID: 31359053; PubMed Central PMCID: PMCPMC7286366.
Wee BYH, Lee JH, Mok YH, Chong SL. A narrative review of heart rate and variability in sepsis. Ann Transl Med. 2020;8(12):768. doi: 10.21037/atm-20-148. PubMed PMID: 32647693; PubMed Central PMCID: PMCPMC7333166.
Ting PZY, Ho AFW, Lin X, Shahidah N, Blewer A, Ng YY, Leong BS, Gan HN, Mao DR, Chia MYC, Cheah SO, Ong MEH. Nationwide trends in residential and non-residential out-of-hospital cardiac arrest and differences in bystander cardiopulmonary resuscitation. Resuscitation. 2020;151:103-10. Epub 20200323. doi: 10.1016/j.resuscitation.2020.03.007. PubMed PMID: 32217133.
Tan BYQ, Tan JTC, Cheah D, Zheng H, Pek PP, De Silva DA, Ahmad A, Chan BPL, Chang HM, Kong KH, Young SH, Tang KF, Tu TM, Yeo LL, Venketasubramanian N, Ho AFW, Ong MEH. Long-Term Trends in Ischemic Stroke Incidence and Risk Factors: Perspectives from an Asian Stroke Registry. J Stroke. 2020;22(3):396-9. Epub 20200810. doi: 10.5853/jos.2020.00878. PubMed PMID: 32773723; PubMed Central PMCID: PMCPMC7568973.
Subramaniam A, Tan RMR, Chan D, Ng ZM, Dong CY, Feng JXY, Chong SL. Assessment of the Understanding of Concussion and Care Protocols Amongst Student Athletes and Coaches: A Qualitative Study. Front Pediatr. 2020;8:526986. Epub 20200924. doi: 10.3389/fped.2020.526986. PubMed PMID: 33072670; PubMed Central PMCID: PMCPMC7542181.
Seah PZ, Chee J, Feng JXY, Ting YS, Chong SL. Risk Stratification of Paediatric Sports Injuries Seen at a Tertiary Hospital. Ann Acad Med Singap. 2020;49(12):955-62. doi: 10.47102/annals-acadmedsg.2020262. PubMed PMID: 33463653.
Pek JH, Yap BJ, Gan MY, Seethor STT, Greenberg R, Hornik CPV, Tan B, Lee JH, Chong SL. Neurocognitive impairment after neonatal sepsis: protocol for a systematic review and meta-analysis. BMJ Open. 2020;10(6):e038816. Epub 20200611. doi: 10.1136/bmjopen-2020-038816. PubMed PMID: 32532785; PubMed Central PMCID: PMCPMC7295426.
Pek JH, Gan MY, Yap BJ, Seethor STT, Greenberg RG, Hornik CPV, Tan B, Lee JH, Chong SL. Contemporary trends in global mortality of sepsis among young infants less than 90 days old: protocol for a systematic review and meta-analysis. BMJ Open. 2020;10(7):e038815. Epub 20200731. doi: 10.1136/bmjopen-2020-038815. PubMed PMID: 32737098; PubMed Central PMCID: PMCPMC7398098.
Nadarajan GD, Omar E, Abella BS, Hoe PS, Do Shin S, Ma MH, Ong MEH. A conceptual framework for Emergency department design in a pandemic. Scand J Trauma Resusc Emerg Med. 2020;28(1):118. Epub 20201217. doi: 10.1186/s13049-020-00809-7. PubMed PMID: 33334364; PubMed Central PMCID: PMCPMC7745175.
Mao DR, Ee AZQ, Leong PWK, Leong BS, Arulanandam S, Ng M, Ng YY, Siddiqui FJ, Ong MEH. Is your unconscious patient in cardiac arrest? A New protocol for telephonic diagnosis by emergency medical call-takers: A national study. Resuscitation. 2020;155:199-206. Epub 20200822. doi: 10.1016/j.resuscitation.2020.08.009. PubMed PMID: 32841678.
Lum E, McCreanor V, Luo N, Graves N. Quality of life measured by EQ-5D at different treatment time points for coronary artery disease: protocol for a systematic review and meta-analysis. BMJ Open. 2020;10(7):e039311. Epub 20200729. doi: 10.1136/bmjopen-2020-039311. PubMed PMID: 32727739; PubMed Central PMCID: PMCPMC7394179.
Looi DSH, Goh MSL, Goh SSM, Goh JL, Sultana R, Lee JH, Chong SL. Protocol for a systematic review and meta-analysis of long-term neurocognitive outcomes in paediatric traumatic brain injury. BMJ Open. 2020;10(6):e035513. Epub 20200616. doi: 10.1136/bmjopen-2019-035513. PubMed PMID: 32554743; PubMed Central PMCID: PMCPMC7304810.
Liu N, Chee ML, Niu C, Pek PP, Siddiqui FJ, Ansah JP, Matchar DB, Lam SSW, Abdullah HR, Chan A, Malhotra R, Graves N, Koh MS, Yoon S, Ho AFW, Ting DSW, Low JGH, Ong MEH. Coronavirus disease 2019 (COVID-19): an evidence map of medical literature. BMC Med Res Methodol. 2020;20(1):177. Epub 20200702. doi: 10.1186/s12874-020-01059-y. PubMed PMID: 32615936; PubMed Central PMCID: PMCPMC7330264.
Lin AX, Ho AFW, Cheong KH, Li Z, Cai W, Chee ML, Ng YY, Xiao X, Ong MEH. Leveraging Machine Learning Techniques and Engineering of Multi-Nature Features for National Daily Regional Ambulance Demand Prediction. Int J Environ Res Public Health. 2020;17(11). Epub 20200611. doi: 10.3390/ijerph17114179. PubMed PMID: 32545399; PubMed Central PMCID: PMCPMC7312953.
Lim SL, Smith K, Dyson K, Chan SP, Earnest A, Nair R, Bernard S, Leong BS, Arulanandam S, Ng YY, Ong MEH. Incidence and Outcomes of Out-of-Hospital Cardiac Arrest in Singapore and Victoria: A Collaborative Study. J Am Heart Assoc. 2020;9(21):e015981. Epub 20201023. doi: 10.1161/jaha.119.015981. PubMed PMID: 33094661; PubMed Central PMCID: PMCPMC7763419.
Lim BL, Cheah SO, Goh HK, Lee FCY, Ng YY, Asinas-Tan M, Ong MEH. Long-term effect of hyperoxemia during chronic obstructive pulmonary disease exacerbation managed by emergency medical service and emergency department: a prospective, exploratory study. Eur J Emerg Med. 2020;27(6):461-7. doi: 10.1097/mej.0000000000000727. PubMed PMID: 32516160.
Ho AFW, Ong MEH. Remote Ischemic Conditioning in Acute Myocardial Infarction - Implications of the CONDI-2/ERIC-PPCI Trial for Prehospital and Emergency Medicine. Prehosp Emerg Care. 2020;24(6):862-4. Epub 20200127. doi: 10.1080/10903127.2019.1704324. PubMed PMID: 31986074.
Ho AFW, De Souza NNA, Blewer AL, Wah W, Shahidah N, White AE, Ng YY, Mao DR, Doctor N, Gan HN, Chia MYC, Leong BS, Cheah SO, Tham LP, Ong MEH. Implementation of a National 5-Year Plan for Prehospital Emergency Care in Singapore and Impact on Out-of-Hospital Cardiac Arrest Outcomes From 2011 to 2016. J Am Heart Assoc. 2020;9(21):e015368. Epub 20201026. doi: 10.1161/jaha.119.015368. PubMed PMID: 33103542; PubMed Central PMCID: PMCPMC7763405.
Graves N, Maiti R, Aloweni FAB, Yuh AS, Lo ZJ, Harding K. Pressure injuries among admissions to a hospital in the tropics. Int Wound J. 2020;17(6):1659-68. Epub 20200727. doi: 10.1111/iwj.13448. PubMed PMID: 32720433; PubMed Central PMCID: PMCPMC7948553.
Chong SL, Soo JSL, Allen JC, Jr., Ganapathy S, Lee KP, Tyebally A, Yung CF, Thoon KC, Ng YH, Oh JY, Teoh OH, Mok YH, Chan YH. Impact of COVID-19 on pediatric emergencies and hospitalizations in Singapore. BMC Pediatr. 2020;20(1):562. Epub 20201223. doi: 10.1186/s12887-020-02469-z. PubMed PMID: 33353540; PubMed Central PMCID: PMCPMC7755581.
Chong SL, Dang TK, Loh TF, Mok YH, Bin Mohamed Atan MS, Montanez E, Lee JH, Feng M. Timing of tracheal intubation on mortality and duration of mechanical ventilation in critically ill children: A propensity score analysis. Pediatr Pulmonol. 2020;55(11):3126-33. Epub 20200820. doi: 10.1002/ppul.25026. PubMed PMID: 32797663.
Carter HE, Lee XJ, Dwyer T, O'Neill B, Jeffrey D, Doran CM, Parkinson L, Osborne SR, Reid-Searl K, Graves N. The effectiveness and cost effectiveness of a hospital avoidance program in a residential aged care facility: a prospective cohort study and modelled decision analysis. BMC Geriatr. 2020;20(1):527. Epub 20201207. doi: 10.1186/s12877-020-01904-1. PubMed PMID: 33287716; PubMed Central PMCID: PMCPMC7720399.
Cai Y, Lo JJ, Venkatachalam I, Kwa AL, Tambyah PA, Hsu LY, Barnett A, Marimuthu K, Graves N. The impact of healthcare associated infections on mortality and length of stay in Singapore-A time-varying analysis. Infect Control Hosp Epidemiol. 2020;41(11):1315-20. Epub 20200715. doi: 10.1017/ice.2020.304. PubMed PMID: 32665057.
Blythe R, O'Gorman PM, Crawford RW, Feenan R, Hatton A, Whitehouse SL, Graves N. Fixation Method for Hip Arthroplasty Stem Following Hip Fracture: A Population-Level Cost-Effectiveness Analysis. J Arthroplasty. 2020;35(6):1614-21. Epub 20200208. doi: 10.1016/j.arth.2020.02.001. PubMed PMID: 32197963.
Blewer AL, Ho AFW, Shahidah N, White AE, Pek PP, Ng YY, Mao DR, Tiah L, Chia MY, Leong BS, Cheah SO, Tham LP, Kua JPH, Arulanandam S, Østbye T, Bosworth HB, Ong MEH. Impact of bystander-focused public health interventions on cardiopulmonary resuscitation and survival: a cohort study. Lancet Public Health. 2020;5(8):e428-e36. doi: 10.1016/s2468-2667(20)30140-7. PubMed PMID: 32768435.

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20250513 PERC List of Publications

Research Publications @ PERC

Research Publications @ PERC

09 Sep 2020 – 05 Jan 2026

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