The Lancet One Health Commission: harnessing our interconnectedness for equitable, sustainable, and healthy socioecological systems

This Lancet Commission explores how the One Health approach - recognising the interconnectedness of human, animal, and environmental health can guide us towards fairer, more sustainable societies. It calls for integrated action across sectors to tackle the root causes of health inequities, environmental degradation, and zoonotic disease threats.

Key messages include:

• Health and sustainability are deeply interlinked and must be addressed through collaborative, cross-sectoral governance
• One Health should move beyond emergency response to promote long-term planetary health and equity
• Investment in systems thinking, education, and locally led research is crucial to address complex global challenges
• Tackling power imbalances and structural inequities in global health decision-making is essential for lasting impact