Grant Awards

Grant Awards

The Goh Cardiovascular Research Awards (GCRA)

The Goh Cardiovascular Research Award (GCRA) is a funding award made possible by the generous gift from the Goh Foundation. The award aims to support and enhance cardiovascular research impact at Duke-NUS Medical School and National Heart Centre Singapore (NHCS).

The GCRA provides seed funding for innovative pilot studies that explore novel hypotheses and new research directions distinct from existing projects. It prioritises ideas that address critical scientific challenges and unmet needs needs in cardiometabolomic biology and medicine.

By fostering interdisciplinary collaboration across laboratory and departments, the GCRA aims to strengthen research capabilities and catalyse the development of larger, team-based proposals for external competitive funding. Through this initiative, Duke-NUS Medical School reaffirms its commitment to pioneering cardiovascular research that translates to better health outcomes.

GCRA Nov 2024 Grant Call Awardees

Associate Professor Manvendra Singh

PROJECT NO.:

Duke-NUS-GCR/2025/0039

PROJECT TITLE:

TO DETERMINE THE ROLE OF RNA-BINDING PROTEIN RBPMS2 IN CARDIOMYOPATHY

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Associate Professor Wang Xiaomeng

PROJECT NO.:

Duke-NUS-GCR/2025/0040

PROJECT TITLE:

EXPLORING BCAA METABOLISM IN RETINAL HEALTH: A POTENTIAL THERAPEUTIC STRATEGIES FOR TREATING BLINDING EYE DISEASES

HOST INSTITUTION:

Duke-NUS Medical School, Centre for Vision Research (CVR)

Clinical Professor (Duke NUS); Senior Consultant (SGH) Wang Yee Moon Angela

PROJECT NO.:

Duke-NUS-GCR/2025/0041

PROJECT TITLE:

A PROTEOMICS-BASED APPROACH TO ELUCIDATE NOVEL BIOMARKERS IN PROGRESSIVE VASCULAR CALCIFICATION IN PATIENTS WITH KIDNEY FAILURE

HOST INSTITUTION:

Singapore General Hospital / Renal Medicine, Medicine Academic Clinical Programme (Med ACP)

Professor Ong Sin Tiong

PROJECT NO.:

Duke-NUS-GCR/2025/0045

PROJECT TITLE:

REDUCING BODY NA+ CONTENT BY INCREASING DIETARY K+ INTAKE IN PATIENTS WITH ESSENTIAL HYPERTENSION

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Associate Professor Chen Jinmiao

PROJECT NO.:

Duke-NUS-GCR/2025/0045

PROJECT TITLE:

REDUCING BODY NA+ CONTENT BY INCREASING DIETARY K+ INTAKE IN PATIENTS WITH ESSENTIAL HYPERTENSION

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Professor David Silver

PROJECT NO.:

Duke-NUS-GCR/2025/0045

PROJECT TITLE:

REDUCING BODY NA+ CONTENT BY INCREASING DIETARY K+ INTAKE IN PATIENTS WITH ESSENTIAL HYPERTENSION

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Associate Professor Jens Titze

PROJECT NO.:

Duke-NUS-GCR/2025/0045

PROJECT TITLE:

REDUCING BODY NA+ CONTENT BY INCREASING DIETARY K+ INTAKE IN PATIENTS WITH ESSENTIAL HYPERTENSION

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

GCRA Mar 2024 Grant Call Awardees

Associate Professor and Director Enrico Petretto

PROJECT NO.:

Duke-NUS-GCR/2024/0033

PROJECT TITLE:

TARGETING WWP2 IN ESSENTIAL CELLULAR NICHES WITH HUMAN LUNG ORGANOIDS: A NOVEL APPROACH TO MITIGATE PULMONARY FIBROSIS

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Associate Professor Jacques Behmoaras

PROJECT NO.:

Duke-NUS-GCR/2024/0034

PROJECT TITLE:

TESTING A NOVEL ANTI-AGEING COMPOUND IN CARDIOVASCULAR AND SYSTEMIC SENESCENCE

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Senior Consultant Tan Hong Chang

PROJECT NO.:

Duke-NUS-GCR/2024/0035

PROJECT TITLE:

DYSREGULATED HEPATIC GLYCINE CONJUGATION DETOXIFICATION PATHWAY: THE MISSING METABOLIC LINK BETWEEN NONALCOHOLIC FATTY LIVER DISEASE AND HEART FAILURE WITH PRESERVED EJECTION FAILURE.

HOST INSTITUTION:

Singapore General Hospital / Medicine

Assistant Professor Anissa Widjaja

PROJECT NO.:

Duke-NUS-GCR/2024/0038

PROJECT TITLE:

SPATIAL MULTI-OMICS STUDY OF MECHANISM OF NANOPARTICLE-INDUCED CARDIAC PROTECTION AND REPAIR FOLLOWING ACUTE MYOCARDIAL INFARCTION

HOST INSTITUTION:

National Heart Centre Singapore / National Heart Research Institute Singapore, Cardiovascular Sciences Academic Clinical Programme (CVS ACP)

Professor David Silver

PROJECT NO.:

Duke-NUS-GCR/2024/0038

PROJECT TITLE:

SPATIAL MULTI-OMICS STUDY OF MECHANISM OF NANOPARTICLE-INDUCED CARDIAC PROTECTION AND REPAIR FOLLOWING ACUTE MYOCARDIAL INFARCTION

HOST INSTITUTION:

National Heart Centre Singapore / National Heart Research Institute Singapore, Cardiovascular Sciences Academic Clinical Programme (CVS ACP)

Junior Principal Investigator Lu Shengjie @ Lyu Shengjie

PROJECT NO.:

Duke-NUS-GCR/2024/0038

PROJECT TITLE:

SPATIAL MULTI-OMICS STUDY OF MECHANISM OF NANOPARTICLE-INDUCED CARDIAC PROTECTION AND REPAIR FOLLOWING ACUTE MYOCARDIAL INFARCTION

HOST INSTITUTION:

National Heart Centre Singapore / National Heart Research Institute Singapore, Cardiovascular Sciences Academic Clinical Programme (CVS ACP)

GCRA Mar 2023 Grant Call Awardees

Assistant Professor Lena Ho

PROJECT NO.:

Duke-NUS-GCR/2023/0029

PROJECT TITLE:

DEFINING THE TRANSLATIONAL LANDSCAPE OF HEART FAILURE WITH PRESERVED EJECTION FRACTION

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Associate Professor Sun Lei

PROJECT NO.:

Duke-NUS-GCR/2023/0030

PROJECT TITLE:

PATHOLOGICAL IMPACT ON RNA ISOFORM USAGE IN HEART: MECHANICAL VS. METABOLIC

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Associate Professor Xiaomeng Wang

PROJECT NO.:

Duke-NUS-GCR/2023/0031

PROJECT TITLE:

GENERATE VEGFXLRG1 BISPECIFIC ANTIBODIES AND EVALUATE THEIR EFFICACY IN OCULAR ANGIOGENESIS AND FIBROSIS

HOST INSTITUTION:

Duke-NUS Medical School, Centre for Vision Research (CVR)

Assistant Professor Le Thu Thao

PROJECT NO.:

Duke-NUS-GCR/2023/0032

PROJECT TITLE:

AUTOMATED INLINE MYOCARDIAL PERFUSION MAPPING FOR ASSESSMENT OF NON OBSTRUCTIVE CORONARY ARTERY DISEASE (INOCA) BY CARDIAC MAGNETIC RESONANC

HOST INSTITUTION:

National Heart Centre Singapore, National Heart Research Institute Singapore (NHRIS)

GCRA Nov 2022 Grant Call Awardees

Professor David Silver

PROJECT NO.:

Duke-NUS-GCR/2022/0019

PROJECT TITLE:

THE ROLE OF A LYSOSOMAL LIPID TRANSPORTER IN CARDIAC METABOLISM AND FUNCTION

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Associate Professor Jacques Behmoaras

PROJECT NO.:

Duke-NUS-GCR/2022/0020

PROJECT TITLE:

PATIENT STRATIFICATION FOR EFFECTIVE BIOMARKERS IN OBESITY-INDUCED CARDIOVASCULAR DISEASE

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Assistant Professor Manvendra Singh

PROJECT NO.:

Duke-NUS-GCR/2022/0021

PROJECT TITLE:

CRITICAL ROLE OF THE ATP-DEPENDENT BAF CHROMATIN REMODELING COMPLEX DURING MAMMALIAN HEART DEVELOPMENT

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Assistant Professor Anissa Widjaja

PROJECT NO.:

Duke-NUS-GCR/2022/0022

PROJECT TITLE:

TREATING HEART FAILURE WITH PRESERVED EJECTION FRACTION BY TARGETING BOTH INFLAMMATION AND FIBROSIS WITH A NOVEL THERAPEUTIC MODALITY

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Assistant Professor Ching Jianhong

PROJECT NO.:

Duke-NUS-GCR/2022/0023

PROJECT TITLE:

INVESTIGATING OF METABOLIC REPROGRAMMING ASSOCIATED WITH BCAA CATABOLISM INHIBITION IN PPM1K-/- MOUSE USING STABLE ISOTOPE TRACING TECHNIQUE

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Associate Professor Jens Titze

PROJECT NO.:

Duke-NUS-GCR/2022/0024

PROJECT TITLE:

23NAMRI-DRIVEN QUANTIFICATION OF MUSCLE NA STORAGE FOR DIAGNOSING PATIENTS WITH PRIMARY ALDOSTERONISM

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Professor Paul Yen

PROJECT NO.:

Duke-NUS-GCR/2022/0025

PROJECT TITLE:

EIF5A HYPUSINATION REGULATES CARDIAC FATTY ACID OXIDATION BY MEDIATING SYNTHESIS OF AUTOPHAGIC AND MITOCHONDRIAL PROTEINS

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Professor Wang Linfa

PROJECT NO.:

Duke-NUS-GCR/2022/0026

PROJECT TITLE:

STUDYING EXTREMES OF HUMANS AND BATS TO UNCOVER NOVEL CAUSATIVE AND PROTECTIVE FACTORS IN THE DEVELOPMENT OF CORONARY ARTERY DISEASE

HOST INSTITUTION:

Duke-NUS Medical School, Emerging Infectious Diseases (EID)

Assistant Professor Chrishan Ramachandra

PROJECT NO.:

Duke-NUS-GCR/2022/0027

PROJECT TITLE:

MYELOPEROXIDASE AS A NOVEL THERAPEUTIC TARGET FOR IMPROVING DIASTOLIC DYSFUNCTION IN HEART FAILURE WITH PRESERVED EJECTION FRACTION

HOST INSTITUTION:

National Heart Centre Singapore, National Heart Research Institute Singapore (NHRIS)

Professor Karl Tryggvason

PROJECT NO.:

Duke-NUS-GCR/2022/0028

PROJECT TITLE:

PROMOTING CARDIOMYOCYTES MATURATION THROUGH THE GENETIC MANIPULATION OF METABOLIC GENES

HOST INSTITUTION:

Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Programme (CVMD)

Grant Awards

The Goh Cardiovascular Research Awards (GCRA)

GCRA Nov 2024 Grant Call Awardees

GCRA Mar 2024 Grant Call Awardees

GCRA Mar 2023 Grant Call Awardees

GCRA Nov 2022 Grant Call Awardees

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