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Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice.
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Incorporating kidney disease measures into cardiovascular risk prediction: development and validation in 9 million adults from 72 datasets.
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A deep-learning system for the assessment of cardiovascular disease risk via the measurement of retinal-vessel calibre.
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Choriocapillaris microvasculature dysfunction in systemic hypertension.
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A systematic review and participant-level meta-analysis found little association of retinal microvascular caliber with reduced kidney function.
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Kidney International. 2021 Mar 1;99(3):696-706.
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells.
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Application of machine learning techniques to understand ethnic differences and risk factors for incident chronic kidney disease in Asians.
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Association between Body Mass Index and Chronic Kidney Disease in Asian Populations: A Participant-level Meta-Analysis.
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Maturitas. 2021 Dec 1;154:46-54.
Transformation of Electronic Health Records and Questionnaire Data to OMOP CDM: A Feasibility Study Using SG_T2DM Dataset.
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Segmenting growth of endothelial cells in 6-well plates on an orbital shaker for mechanobiological studies.
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JoVE (Journal of Visualized Experiments) 172 (2021): e61817
Leucine-rich α-2-glycoprotein 1 suppresses endothelial cell activation through ADAM10-mediated shedding of TNF-α receptor.
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LRG1 Promotes Metastatic Dissemination of Melanoma through Regulating EGFR/STAT3 Signalling.
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Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway.
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Combining retinal and choroidal microvascular metrics improves discriminative power for diabetic retinopathy.
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Amino acid profile of skeletal muscle loss in type 2 diabetes: Results from a 7-year longitudinal study in asians.
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Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes
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Urine Leucine-Rich α-2 Glycoprotein 1 (LRG1) Predicts the Risk of Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.
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HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells.
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Prediction of diabetic kidney disease risk using machine learning models: A population-based cohort study of Asian adults.
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Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis.
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Deep learning algorithms to detect diabetic kidney disease from retinal photographs in multiethnic populations with diabetes.
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The American Journal of Pathology 193, no. 12 (2023): 1910-1913.
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Plasma ceramides predict all-cause and cause-specific mortality in individuals with type 2 diabetes.
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The Journal of Clinical Endocrinology & Metabolism 110, no. 5 (2025): 1497-1504.
Plasma proteomics of diabetic kidney disease among Asians with younger-onset type 2 diabetes.
Gurung, Resham Lal, Huili Zheng, Hiromi Wai Ling Koh, Yiamunaa M, Jian-Jun Liu, Sylvia Liu, Clara Chan et al.
The Journal of Clinical Endocrinology & Metabolism 110, no. 2 (2025): e239-e248.
Health economic evaluation of a risk-stratified intervention in diabetic kidney disease.
Kalhan, Tosha A., Miyang Luo, Jia Hui Chai, E. Shyong Tai, Su Chi Lim, Thomas M. Coffman, and Kavita Venkataraman.
Diabetologia 68, no. 10 (2025): 2227-2239.
Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline.
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Diabetologia 68, no. 3 (2025): 557-575.
Use of artificial intelligence with retinal imaging in screening for diabetes-associated complications: systematic review.
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Artificial intelligence in chronic kidney disease management: a scoping review.
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Theranostics 15, no. 10 (2025): 4566.
Methylamine metabolites and progression to kidney failure in type 2 diabetes: An Asian and European prospective study.
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Stem cell therapies for diabetes.
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Nature Medicine 31, no. 7 (2025): 2147-2160.
Beyond lipids: fenofibrate in diabetic retinopathy and nephropathy.
Liu, Mengying, Seok Ting Lim, Weihua Song, Thomas M. Coffman, and Xiaomeng Wang.
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Fasting urine osmolality and risk of kidney disease progression in patients with type 2 diabetes.
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Nephrology Dialysis Transplantation (2025): gfaf264.
Plasma proteins predict kidney function trajectories in type 2 diabetes.
Gurung, Resham L., Huili Zheng, Jia Le Ivan Tan, Sylvia Liu, Keven Ang, Jian-Jun Liu, Thomas M. Coffman, and Su Chi Lim.
The Journal of Clinical Endocrinology & Metabolism 110, no. 11 (2025): 3256-3263.
Urine tricarboxylic acid cycle metabolites and risk of end-stage kidney disease in patients with type 2 diabetes.
Liu, Jian-Jun, Sylvia Liu, Huili Zheng, Janus Lee, Resham L. Gurung, Clara Chan, Lye Siang Lee et al.
The Journal of Clinical Endocrinology & Metabolism 110, no. 2 (2025): e321-e329.
Flow and ischemic changes in retina and choroid across diabetic retinopathy spectrum: a SS-OCTA study.
Yang, Qianhui, Kelvin YC Teo, Yueheng Hong, Bingyao Tan, Leopold Schmetterer, Chui Ming Gemmy Cheung, Tien Yin Wong, and Gavin Tan Siew Wei.
Eye 39, no. 8 (2025): 1631-1640.
Association of plasma angiogenin with risk of incident end-stage kidney disease in individuals with type 2 diabetes.
Gurung, Resham L., Jian-Jun Liu, Sylvia Liu, Janus Lee, Huili Zheng, Clara Chan, Keven Ang, and Su Chi Lim.
Diabetes 74, no. 6 (2025): 998-1006.
Probability of progression and regression of chronic kidney disease in patients with type 2 diabetes mellitus.
Koh, Barry Moses Quan Ren, Feng He, Gavin Siew Wei Tan, Cynthia Ciwei Lim, Kavita Venkataraman, and Charumathi Sabanayagam.
Maturitas 198 (2025): 108599.
Novel eGFR equations and cardiovascular outcomes in a multiethnic Asian cohort.
Liew, Zhong Hong, Miao Li Chee, Riswana Banu, Yulia Liem, Ching-Yu Cheng, Cynthia Ciwei Lim, and Charumathi Sabanayagam.
Clinical Kidney Journal 18, no. 10 (2025): sfaf289.
Seeing the Heart through the Eye: Retinal Imaging for Cardiovascular Risk in CKD.
Sabanayagam, Charumathi, and Cynthia Ciwei Lim.
Kidney360 7, no. 1 (2026): 4-6.
Integrative metabolomic and proteomic analysis of diabetic kidney disease progression with younger‐onset type 2 diabetes.
Gurung, Resham Lal, Huili Zheng, Jia Le Ivan Tan, Sylvia Liu, Clara Chan, Keven Ang, Clara Tan et al.
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Growth-differentiation factor 15 (GDF-15) is associated with arterial stiffness and impaired endothelial function with mediation by albuminuria in the Singapore study of macroangiopathy and microvascular reactivity in type 2 diabetes (SMART2D) cohort.
Low, Serena, Angela Moh, Huili Zheng, Keven Ang, Wern Ee Tang, Ziliang Lim, Tavintharan Subramaniam, Chee Fang Sum, and Su Chi Lim.
Endocrine 89, no. 3 (2025): 736-744.
Plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) and the risk of chronic kidney disease progression in patients with type 2 diabetes.
Liu, Jian‐Jun, Sylvia Liu, Janus Lee, Huili Zheng, Resham L. Gurung, Keven Ang, Huijuan Wu, and Su Chi Lim.
Diabetes, Obesity and Metabolism 27, no. 8 (2025): 4446-4453.
Retinal Neuronal Changes and Kidney Dysfunction in Diabetes Mellitus.
Cao, Dan, Qianhui Yang, Yueheng Hong, Rose Tan, Farah NI Ibrahim, Cynthia Lim, Jason Choo et al.
Clinical & Experimental Ophthalmology 53, no. 9 (2025): 1168-1180.
Integrative Metabolomic and Proteomic Analysis of Diabetic Kidney Disease Progression with Younger-Onset Type 2 Diabetes.
Resham Lal GURUNG, Huili ZHENG, Jia Le Ivan TAN, Sylvia LIU, Clara CHAN, Keven ANG, Clara TAN, Jian-Jun LIU, Tavintharan SUBRAMANIAM, Chee Fang SUM, Su Chi LIM.
Diabetes Obes Metab. 2025;27:7454–7463
Urine choline oxidation metabolites predict chronic kidney disease progression in patients with type 2 diabetes.
Liu, Jian-Jun, Sylvia Liu, Resham L. Gurung, Janus Lee, Huili Zheng, Keven Ang, Clara Chan et al.
The Journal of Clinical Endocrinology & Metabolism 111, no. 1 (2026): e225-e233.
Cluster analysis of younger-onset type 2 diabetes in a multi-ethnic Asian population reveals distinct diabetes subgroups with differential pathophysiology, molecular signatures and clinical outcomes.
Tan Si Hua Clara, Kee Kai Xiang, Zheng Huili, Wong Kay Wye Sabrina, Chan Wan Ting Lovynn, Song Yuzhen, Ang Keven, Tavintharan Subramaniam, Sum Chee Fang, Lim Su Chi.
Diabetes. 2026 Mar 1;75(3):526-537
Urine branched-chain amino acid excretion and chronic kidney disease progression in patients with type 2 diabetes.
Jian-Jun Liu, Sylvia Liu, Huili Zheng, Chin-Pin Wang, Subrata Debnath, Janus Lee, Lye Siang Lee, Jianhong Ching, Ming Shen Tham, Keven Ang, Resham L Gurung, Thomas M Coffman, Kumar Sharma, Su Chi Lim.
Diabetes 2026;75(2):351–360
Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end stage renal disease.
Zhou, Xiaohong, Dianchun Shi, Jinjin Xu, Ling Wang, Resham Lal Gurung, Zhiming Ye, M. Yiamunaa, Meng Wang, Dongying Fu, Wei Chen, Jinghong Zhao, Hua Gan, Ping Fu, Xiaojun Tan, Jihong Chen, Yaozhong Kong, Haiqiang Zhang, Ming Li, Rajkumar Dorajoo, Xin Jin, Su Chi Lim, Xueqing Yu, Jianjun Liu.
Nature Communications (2026).
Precision Approaches to Kidney Disease in Asia: Perspectives from Singapore
Huimei Chen, Shih Wee Seow, Thomas Coffman, Patrick Tan, Enrico Petretto
Journal of the American Society of Nephrology, 2026
Models of hyperglycaemia in diabetes mellitus and its complications.
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