Directory

Swee-Liew Wadsworth Publication Award-Gold

National University of Singapore,2021

Swee-Liew Wadsworth Publication Award-Gold

2020

Swee-Liew Wadsworth Research Award

National University of Singapore,2020

Yong Loo Lin School of Medicine Research Excellence Award

National University of Singapore,2019

Swee-Liew Wadsworth Publication Award-Gold

National University of Singapore,2019

Swee-Liew Wadsworth Publication Award-Gold

National University of Singapore,2018

Swee-Liew Wadsworth Research Award

National University of Singapore,2017

Swee-Liew Wadsworth Research Award

National University of Singapore,2015

Deciphering lipid dysfunction in amyotrophic lateral sclerosis: insight from lipidomic and metabolic studies

Translational Neurodegeneration – Agrawal I, Lim YS, Ng SY, Ling, S.-C.* (2022)

11 (1); 48-N.A

Identification of itanapraced as a potential novel therapeutic drug for LRRK2-linked Parkinson’s disease

Science Signaling – Zhang ZW., Tu H, Jiang M, Vana S, Chia SY, Saw WT, Ma DR, Zhou ZD, Xu J, Guo KH, Yu WP, Ling, S.-C., Margolin RA, Chain DG, Zeng L, Tan EK (2022)

15 (748); eabk3411-N.A

CNS cholesterol metabolism in health and disease

IUBMB life – Ho WY, Hartmann H, Ling, S.-C.* (2022)

74 (8); 826-841

A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery

Nature Communications – Tan HWS, Lu G, Cho YL, Dong H, Wang L, Auginia N, Chan C, Kappei D, Shao H, Ling, S.-C., Taneja R, Tsai SY, Ding WX, Shen HM (2022)

13 (3720); N.A-N.A

Blood microRNA-150-5p as a novel biomarker for Alzheimer’s disease: correlation with cognition, CSF Abeta, neuroimaging and post-mortem tissues

Journal of Alzheimer’s Disease – Chia SY, Vipin A, Ng KP, Bommakanti AS, Tu H, Wang BZ, Farah F, Ng ASL, Ling, S.-C., Okamura K, Tan EK, Kandiah N, Zeng L (2022)

10.3233 (JAD-220116); N.A-N.A

Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?

FEBS Journal – Hartmann H, Ho WY, Chang JC, Ling, S.-C.* (2021)

doi: 10.1111 (febs.16175); N.A-N.A

TDP-43 represses a cryptic exon in Schwann cells to ensure rapid saltatory conduction

eLIFE – Chang KJ, Agrawal I, Vainshtein A, Ho WY, Xin W, Tucker-Kellogg G, Susuki K, Peles, Ling, S.-C.*, Chan J. R.* (2021)

10 e64456-N.A

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination

J. Cell Biol. – Ho WY#, Chang JC#, Lim K#, Cazenave-Gassiot A, Nguyen AT, Foo JC, Muralidharan S, Viera-Ortiz, A, Ong SJM, Agrawal I, Hoon S, Arogundade OA, Rodriguez MJ, Lim SM, Kim SH, Wenk MR, Lee EB, Ravits J, Tucker-Kellogg G, Ling, S.-C.* (2021)

220 (9); e201910213-N.A

Dysfunctions in RNA- and protein-homeostasis and mitochondrial functions in ALS-FUS mouse model with hippocampus-mediated cognitive deficits

Acta Neuropathol Commun – Ho, W.Y., Tyan, S.-H., Chang, W.T., Yen, Y.C. Lim, K, Tan, B.S.Y., Ong, J., Wong, P., Tucker-Kellogg, G., Koo, E., Ling, S.-C.* (2021)

9 9-N.A

Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction

Proc Natl Acad Sci U S A – Peng AYT#, Agrawal I#, Ho WY#, Yen YC, Pinter AJ, Liu J, Phua QXC, Koh KB, Chang JC, Sanford E, Man JHK, Wong P, Gutmann DH, Tucker-Kellogg G, Ling, S.-C.* (2020)

117 (46); 29101-29112

The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43

Neurobiology of Aging – Wong, P, Ho, W. Y., Yen Y.-C., Ling, S.-C.* (2020)

92 43-60

FUS-mediated down-regulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits

Hum Mol Gene – Ho, W.Y., Tyan, S.-H., Chang, W.T., Yen, Y.C. Lim, K, Tan, B.S.Y., Ong, J., Wong, P., Tucker-Kellogg, G., Koo, E., Ling, S.-C.* (2019)

28 (22); 3777-3791

C9orf72 Intermediate Repeats are associated with Corticobasal Degeneration, increased C9orf72 expression and disruption of autophagy

Acta Neuropathologica – Cali, C. P., Patino, M., Tai, Y. T., Ho, W. Y., McLean., CA, Morris CM, Seeley WW, Miller BL, Gaig, C., Vonsattel JP, White CL., Roeber S., Kretzshmar H., Troncoso JC., Troakes C., Gearing M., Ghetti, B., Van Deerlin, V. M., Lee, V. M., Trojanowski, J. Q., Mok, K. Y., Ling, H., Dickson, D. W., Schellenberg, G. D., Ling, S.-C. and Lee, E. B. (2019)

14 26-42

Elevated FUS levels by overriding its autoregulation produce gain-of-toxicity properties that disrupt protein and RNA homeostasis

Autophagy – Ho, W.Y., and Ling, S.-C.* (2019)

15 (9); 1665-1667

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

eLIFE – Ling, S.-C.*, Dastidar, S. G., Tokunaga, S., Ho, W. Y., Lim, K., Ilieva, H., Parone¬, P. A., Tyan, S. H., Tse, T.M., Chang, J.C., Platoshyn, O., Bui, N. B., Bui, A. T., Vetto, A. P., Sun, S., McAlonis-Downes, M., Han, J. S., Swing, D., Kapeli, K., Yeo, G. W., Tessarollo, L., Marsala, M., Shaw, C. E., Tucker-Kellogg, G., La Spada, A. R., Lagier-Tourenne, C., Da Cruz, S., and Cleveland, D. W.* (2019)

8 602-N.A

The ALS/FTD-linked gene product, C9ORF72, regulates neuronal morphogenesis via autophagy

Autophagy – Ho, W.Y., Tai, Y.K., Liang, L., Tyan, S.-H., Chen, S., Guan, J.-L., Zhuo, H., Shen, H.-M., Koo, E., Ling, S.-C.* (2019)

15 (5); 827-842