“Story of Arboviral Lifecycle: Acquisition Mechanism From Hosts to Mosquitoes”

Start Date & Time: 
Friday, 2 November, 2018 - 16:00
End Date & Time: 
Friday, 2 November, 2018 - 17:00
Venue: 

Meeting Room 7C (Level 7)
Duke-NUS Medical School
8 College Road
Singapore 169857

 

Speaker Details: 

Gong Cheng Principal Investigator
School of Medicine Tsinghua University
China

Synopsis: 

Arboviruses naturally circulate between vertebrate hosts and an arthropod vectors. Viral acquisition from an infected mammalian host by a vector is one of essential steps in their lifecycles. However, little information is available regarding the molecular mechanisms underlying the viral acquisition by arthropod vectors. Here, we will introduce multiple mechanisms in mosquito-borne viral acquisition, including: 1) the hematophagous nature of mosquitoes contributes to arboviral acquisition after a blood meal, via suppressing antiviral innate immunity by activating the GABAergic pathway; 2) Nonstructural protein-1 (NS1), which is abundantly secreted into the serum of an infected host, is a key factor for flavivirus acquisition from infected hosts to fed mosquitoes; 3) A gut commensal bacteria promote mosquito susceptibility to arboviruses by blood meal.

Altogether, our studies demonstrate that arboviruses smartly utilize multiple materials, either produced in their vertebrate phases or existing in vectors, to enhance their acquisition by vectors, therefore facilitating arbovirus survival in nature.

Biography: 

Gong Cheng is a Principal Investigator at Tsinghua University School of Medicine. He received the Ph.D. of Microbiology from Fudan University in 2008. From 2008 to 2012, Dr. Cheng served as a Postdoctoral Associate with Prof. Erol Fikrig at Yale University and Howard Hughes Medical Institute (HHMI).

Dr. Cheng currently leads a research unit studying the pathogenesis and immune responses of flaviviral infections in both hosts and vectors. Dengue, Zika, Japanese encephalitis and West Nile viruses are areas of particular interest. Studies are directed at understanding the molecular basis of viral infection, virulence and transmission by animal and mosquito models.

Host: 

Professor Linfa Wang
Director
Programme in Emerging Infectious Diseases

Contact Person: 

Shirley William
shirleywilliam@duke-nus.edu.sg