Duke-NUS - Pre-hospital & Emergency Research Centre

Professor Crowston conducts laboratory and clinic-based research in glaucoma and related optic neuropathies. His lab is investigating how ageing renders the optic nerve vulnerable to glaucoma with the goal of promoting neurorecovery and developing optic nerve-targeted treatments.

His broad research interests cover:

- Glaucoma

- Ageing

- Resilience

- Optic nerve

- Ophthalmology

- Neurodegeneration

- Neuroprotection

- Lifestyle interventions

- Mitochondrial dysfunction

- Visual field

Systemic TRPV4 inhibition worsens retinal response to acute intraocular pressure elevation in older but not younger mice

Optometry and Vision Science – Lee, P., Bui, B., Greferath, U., Zhao, D., Huang, J., Wang, A., Vessey, K., Chrysostomou, V., Fletcher, E., Crowston, J.  (2025)

102 (2); 78-89

The Effect of Advancing Age and Intraocular Pressure Injury on Retinal Ganglion Cell Function and Synaptic Connectivity

The Effect of Advancing Age and Intraocular Pressure Injury on Retinal Ganglion Cell Function and Synaptic Connectivity – Chrysostomou, V., Crowston, J., Ellis, S., Fry, L., Hatch, R., Fahy, E., Bell, K., Trounce, I., van Wijngaarden, P., Petrou, S (2025)

A new model of axon degeneration in the mouse optic nerve using repeat intraocular pressure challenge

Experimental Eye Research – Chrysostomou, V., Bell, K., Ng, S., Suresh, S., Karthik, G., Millet, M., Chung, Y., Crowston, J (2024)

238 (109722);

Does Bevacizumab Improve Outcomes after Ahmed Glaucoma Valve Implantation for Refractory Glaucoma?: A Meta-Analysis

Journal of Glaucoma – Tran, L., Vo, J., Bell, K., Perera, S., Crowston, J (2024)

33 (6); 444-455

SenMayo transcriptomic senescence panel highlights glial cells in the ageing mouse and human retina

npj Aging – Suresh, S., Karthik, G., Ouyang, J., Chrysostomou, V., Tang, S., Petretto, E., Crowston, J., Bell, K (2024)

10 (1);

Targeting diet and exercise for neuroprotection and neurorecovery in glaucoma

Cells – Tribble, J., Hui, F., Jöe, M., Bell, K., Chrysostomou, V., Crowston, J., Williams, P (2021)

10.0 (2); 1-20

Effects of age on retinal macrophage responses to acute elevation of intraocular pressure

Experimental Eye Research – Kezic, J., Chrysostomou, V., McMenamin, P., Crowston, J (2020)

193

Nox4 facilitates tgfβ1-induced fibrotic response in human tenon’s fibroblasts and promotes wound collagen accumulation in murine model of glaucoma filtration surgery

Antioxidants – Shah, M., Chan, E., Van Bergen, N., Pandav, S., Ng, S., Crowston, J., Peshavariya, H (2020)

48.0 (7); 903-914

Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response

PloS One – Lopez Sanchez, M., Ziemann, M., Bachem, A., Makam, R., Crowston, J., Pinkert, C., McKenzie, M., Bedoui, S., Trounce, I. (2020)

15.0 (10);

Prevalence and associations of non-retinopathy ocular conditions among older Australians with self-reported diabetes: The National Eye Health Survey

International Journal of Ophthalmology – Foreman, J., Keel, S., McGuinness, M., Crowston, J., Taylor, H., Dirani, M. (2020)

13.0 (10); 1642-1651

Short-term changes in the photopic negative response following intraocular pressure lowering in glaucoma

Investigative Ophthalmology & Visual Science – Tang, J., Hui, F., Hadoux, X., Soares, B., Jamieson, M., van Wijngaarden, P., Coote, M., Crowston, J (2020)

61.0 (10);

Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

Molecular Neurobiology – Cimdins, K., Waugh, H., Chrysostomou, V., Lopez Sanchez, M., Johannsen, V., Cook, M., Crowston, J., Hill, A., Duce, J., Bush, A., et al (2019)

56.0 (8); 5471-5482

Bleb-associated endophthalmitis: Proportion, presentation, management and outcomes in Victoria, Australia

Clinical and Experimental Ophthalmology – Kwon, H., Kumar, H., Green, C., Crowston, J., McGuinness, M., Kerr, N (2019)

47.0 (5); 588-597

Improving the Feasibility of Glaucoma Clinical Trials Using Trend-Based Visual Field Progression End Points

Ophthalmology Glaucoma – Wu, Z., Crabb, D., Chauhan, B., Crowston, J., Medeiros, F (2019)

2.0 (2); 72-77

Transnational review of visual standards for driving: How Australia compares with the rest of the world

Clinical and Experimental Ophthalmology – Yan, M., Kumar, H., Kerr, N., Medeiros, F., Sandhu, S., Crowston, J., Kong, Y. (2019)

47.0 (7); 847-863

Visual recovery as the target for glaucoma

Die Ophthalmologie – Chrysostomou, V., Hatch, R., Colgan, T., Paul, J., van Wijngaarden, P., Trounce, I., Lopez Sanchez, M., Bell, K., Grus, F., Crowston, J. (2019)

116.0 (1); 14-17

Prevalence of glaucoma in the Australian National Eye Health Survey

British Journal of Ophthalmology – Keel, S., Xie, J., Foreman, J., Lee, P., Alwan, M., Fahy, E., van Wijngaarden, P., Fan Gaskin, J., Ang, G., Crowston, J., et al (2019)

103.0 (2); 191-195