Tan Puay Hoon


Academic Chair, SingHealth Duke-NUS Pathology Academic Clinical Programme

Senior Consultant and Chairman, Division of Pathology, Singapore General Hospital

Professor, Duke-NUS Medical School

Professor, Department of Anatomy, Yong Loo Lin School of Medicine, NUS


Professor Tan Puay Hoon is Senior Consultant Histopathologist and Chairman, Division of Pathology, Singapore General Hospital, Singapore. She has active interests in breast, urologic and renal pathology, and was a Volume Editor of the 2012 WHO Classification of Tumours of the Breast.  She sits on the Editorial Boards of Modern Pathology, Breast Cancer Research, Journal of Clinical Pathology, Pathology, Seminars in Diagnostic Pathology, and Analytical and Quantitative Cytology and Histology. She is Associate Editor of Histopathology and the Singapore Medical Journal. Apart from a busy service largely focused on subspecialty surgical signouts, she and her collaborators are recipients of several research grants related to translational studies of breast and prostate cancer. She is author of more than 400 publications, and participates regularly in regional and international meetings.

Professor Tan’s research interests in breast pathology centre around the classification of breast fibroepithelial lesions and their molecular pathogenesis, triple negative breast cancers, and ductal carcinoma in situ. In urologic pathology, she is engaged in prostate and renal cancer studies and is a contributor to the 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs.

She is the immediate Past-President of the International Society of Breast Pathology, and was Councillor for Asia of the International Society of Urological Pathology (2009 – 2015).

  • National Outstanding Clinician Award, National Medical Excellence Awards (Ministry of Health Singapore) (2015)
  • SingHealth GCEO Outstanding Clinician Award (2015)
  • The Long Service Medal 2015 (MOH), National Day Awards (2015)
  • Singapore Society of Pathology - Becton Dickinson (BD) Award in Pathology (2015)
Research Interests:

Breast pathology, focusing on the classification of breast fibroepithelial lesions and their molecular pathogenesis, triple negative breast cancer, and ductal carcinoma in situ. In urologic pathology, she collaborates on research in kidney and prostate cancers.

Selected Publications:

Lim SZ, Selvarajan S, Thike AA, Nasir ND, Tan BK, Ong KW, Tan PH. Breast sarcomas and malignant phyllodes tumours: comparison of clinicopathological features, treatment strategies, prognostic factors and outcomes. Breast Cancer Res Treat. 2016 Sep;159(2):229- 44. doi: 10.1007/s10549-016-3946-1. Epub 2016 Aug 19. PubMed PMID: 27541020. JIF (2015): 4.085

Kweldam CF, Nieboer D, Algaba F, Amin MB, Berney DM, Billis A, Bostwick DG, Bubendorf L, Cheng L, Compérat E, Delahunt B, Egevad L, Evans AJ, Hansel DE, Humphrey PA, Kristiansen G, van der Kwast TH, Magi-Galluzzi C, Montironi R, Netto GJ, Samaratunga H, Srigley JR, Tan PH, Varma M, Zhou M, van Leenders GJ. Gleason grade 4 prostate adenocarcinoma patterns: an interobserver agreement study among genitourinary pathologists. Histopathology. 2016 Sep;69(3):441-9. doi: 10.1111/his.12976. Epub 2016 May 24. PubMed PMID: 27028587. JIF (2015): 3.425

Cheng CL, Azhar R, Sng SH, Chua YQ, Hwang JS, Chin  JP,  Seah WK, Loke JC,  Ang RH, Tan   PH. Enabling digital pathology in the diagnostic setting: navigating through the implementation journey in an academic medical centre. J Clin Pathol. 2016 Sep;69(9):784- 92. doi: 10.1136/jclinpath-2015-203600. Epub 2016 Feb 12. PubMed PMID: 26873939. JIF (2015): 2.912

Chng TW, Lee JY, Lee CS,  Li H, Tan MH, Tan PH.  Validation  of the Singapore  nomogram for outcome prediction in breast phyllodes tumours: an Australian cohort. J Clin Pathol. 2016 Jul 27. pii: jclinpath-2016-203951. doi: 10.1136/jclinpath-2016-203951. [Epub ahead of print] PubMed PMID: 27466383. JIF (2015): 2.912

Tan BY, Thike AA, Ellis IO, Tan PH. Clinicopathologic Characteristics of Solid Papillary Carcinoma of the Breast. Am J Surg Pathol. 2016 Jul 19. [Epub ahead of print] PubMed PMID: 27438988. JIF (2015): 4.951

Lim SZ, Ong KW, Tan BK, Selvarajan S, Tan PH. Sarcoma of the breast: an update on a rare entity. J Clin Pathol. 2016 May;69(5):373-81. doi: 10.1136/jclinpath-2015-203545. Epub   2016 Jan 4. Review. PubMed PMID: 26729013. JIF (2015): 2.912

Tan WJ, Chan JY, Thike AA, Lim JC, Md Nasir ND, Tan JS, Koh VC, Lim WK, Tan J, Ng CC, Rajasegaran V, Nagarajan S, Bay BH, Teh BT, Tan PH. MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and  oestrogen  receptor expression. J Clin Pathol. 2016 Apr 7. pii: jclinpath-2015-203590. doi: 10.1136/jclinpath- 2015-203590. [Epub ahead of print] PubMed PMID: 27056456. JIF (2015): 2.912

Matsumoto H, Thike AA, Li H, Yeong J, Koo SL, Dent RA, Tan PH, Iqbal J. Increased CD4    and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer. Breast Cancer Res Treat. 2016 Apr;156(2):237-47. doi: 10.1007/s10549-016- 3743-x. Epub 2016 Mar 9. PubMed PMID: 26960711. JIF (2015): 4.085

Tan WJ, Cima I, Choudhury Y, Wei X, Lim JC, Thike AA, Tan MH, Tan PH. A five-gene    reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions. Breast Cancer Res. 2016 Mar 9;18(1):31. doi: 10.1186/s13058-016-0692-6. PubMed PMID: 26961242; PubMed Central PMCID: PMC4784364. JIF (2015): 5.211 

Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH. Phyllodes tumours of the breast: a consensus review. Histopathology. 2016 Jan;68 (1):5-21. doi: 10.1111/his.12876. Review. PubMed PMID: 26768026. JIF (2015): 3.425

Rakha EA, Badve S, Eusebi V, Reis-Filho JS, Fox SB, Dabbs DJ, Decker T, Hodi Z, Ichihara S, Lee AH, Palacios J, Richardson AL, Vincent-Salomon A, Schmitt FC, Tan PH, Tse GM, Ellis IO. Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management. Histopathology. 2016 Jan;68(1):45-56. doi: 10.1111/his.12861. Review. PubMed PMID: 26348644. JIF (2015): 3.425

Tan J, Ong CK, Lim WK, Ng CC, Thike AA, Ng LM, Rajasegaran V, Myint SS, Nagarajan S, Thangaraju S, Dey S, Nasir ND, Wijaya GC, Lim JQ, Huang D, Li Z, Wong BH, Chan JY, McPherson JR, Cutcutache I, Poore  G, Tay ST, Tan  WJ, Putti  TC,  Ahmad  BS, Iau P, Chan CW, Tang AP, Yong WS, Madhukumar P, Ho GH, Tan  VK, Wong CY, Hartman M, Ong KW,  Tan BK, Rozen SG, Tan P, Tan PH, Teh BT. Genomic landscapes of breast fibroepithelial tumors. Nat Genet. 2015 Nov;47(11):1341-5. doi: 10.1038/ng.3409. Epub 2015 Oct 5. PubMed PMID: 26437033. JIF (2015): 31.616

Koh VC, Lim JC, Thike AA, Cheok PY, Thu MM, Tan VK, Tan BK, Ong KW, Ho GH, Tan WJ, Tan Y, Salahuddin AS, Busmanis I, Chong AP, Iqbal J, Thilagaratnam S, Wong JS, Tan PH. Characteristics and behaviour of screen-detected ductal carcinoma in situ of the breast: comparison with symptomatic patients. Breast Cancer Res Treat. 2015 Jul;152(2):293-304. doi: 10.1007/s10549-015-3472-6. Epub 2015 Jun 16. PubMed PMID: 26077641. JIF (2015): 4.085

Tan PH, Schnitt SJ, van de Vijver MJ, Ellis IO, Lakhani SR. Papillary and neuroendocrine breast lesions: the WHO stance. Histopathology. 2015 May;66(6):761-70. doi: 10.1111/his.12463. Epub 2015 Jan 23. PubMed PMID: 24845113. JIF (2015): 3.425

Tan WJ, Thike AA, Tan SY, Tse GM, Tan MH, Bay BH, Tan PH. CD117 expression in breast phyllodes tumors correlates with adverse pathologic parameters and reduced survival. Mod Pathol. 2015 Mar;28(3):352-8. doi: 10.1038/modpathol.2014.111. Epub 2014 Sep 12. PubMed PMID: 25216225. JIF (2015): 5.485

Rakha EA, Tan PH, Varga Z, Tse GM, Shaaban AM, Climent F, van Deurzen CH, Purnell D, Dodwell D, Chan T, Ellis IO. Prognostic factors in metaplastic carcinoma of the breast: a multi-institutional study. Br J Cancer. 2015 Jan 20;112(2):283-9. doi: 10.1038/bjc.2014.592. Epub 2014 Nov 25. PubMed PMID: 25422911; PubMed Central PMCID: PMC4453452. JIF (2015): 5.569

Choudhury Y, Wei X, Chu YH, Ng LG, Tan HS, Koh V, Thike AA, Poon E, Ng QS, Toh CK, Kanesvaran R, Tan PH, Tan MH. A multigene assay identifying distinct prognostic subtypes of clear cell renal cell carcinoma with differential response to tyrosine kinase inhibition. Eur Urol. 2015 Jan;67(1):17-20. doi: 10.1016/j.eururo.2014.06.041. Epub 2014 Jul 10. PubMed PMID: 25018036. JIF (2015): 14.976

Lim WK, Ong CK, Tan J, Thike AA, Ng CC, Rajasegaran V, Myint SS, Nagarajan S, Nasir ND, McPherson JR, Cutcutache I, Poore  G, Tay ST, Ooi WS,  Tan VK, Hartman M, Ong KW, Tan  BK, Rozen SG, Tan PH, Tan P, Teh BT.  Exome  sequencing  identifies  highly  recurrent MED12 somatic mutations in breast fibroadenoma.  Nat  Genet.  2014  Aug;46(8):877-80. doi: 10.1038/ng.3037. Epub 2014 Jul 20. PubMed PMID: 25038752. JIF (2014): 29.352

Tan WJ, Lai JC, Thike AA, Lim JC, Tan SY, Koh VC, Lim TH, Bay BH, Tan MH, Tan PH. Novel genetic aberrations in breast phyllodes tumours:  comparison between prognostically distinct groups. Breast Cancer Res Treat. 2014 Jun;145(3):635-45. doi: 10.1007/s10549-014- 2982-y. Epub 2014 May 16. PubMed PMID: 24831776. JIF (2014): 3.940

Thike AA, Yong-Zheng Chong L, Cheok PY, Li HH, Wai-Cheong Yip G, Huat Bay B,  Tse   GM, Iqbal J, Tan PH. Loss of androgen receptor expression predicts early recurrence in triple-negative and basal-like breast cancer. Mod Pathol. 2014 Mar;27(3):352-60. doi: 10.1038/modpathol.2013.145. Epub 2013 Aug 9. PubMed PMID: 23929266. JIF (2014): 6.187

Leadership positions / roles in Medical Education: 

  • Course Director, Annual SGH Breast Pathology Course (2010 -  Present)