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Professor Coffman graduated from the University of Pennsylvania and obtained his MD from the Ohio State University College of Medicine. He moved to Duke for medicine residency and nephrology fellowship, joining the faculty in 1985 to pursue a career as a clinician scientist. Along with his leadership of the Division of Nephrology, Professor Coffman was the founding director of the Duke Cardiovascular Research Center and the Duke O’Brien Center for Kidney Research. He joined Duke-NUS in 2010 as Founding Director of the Cardiovascular and Metabolic Disorders SRP and was appointed Dean on 1 July 2015.

An international leader in the field of nephrology, Professor Coffman is a Past-President of the American Society of Nephrology. He is also a member of the American Society for Clinical Investigation and the Association of American Physicians and served on the Nephrology Subspecialty Board of the American Board of Internal Medicine. Professor Coffman has also been member of numerous editorial boards including the Journal of Clinical Investigation, Journal of the American Society of Nephrology, Physiological Reviews and Cell Metabolism. Coffman is a Fellow of the American Society of Nephrology and the Councils for High Blood Pressure Research and the Kidney in Cardiovascular Disease of the American Heart Association (AHA). Professor Coffman also served as Chair of the Steering Committee for the National Institutes of Health (NIH)-funded Animal Models of Diabetes Complications Consortium. His laboratory work has been supported by grants from the NIH, the US Department of Veterans' Affairs, and the Singapore National Research Council (NMRC). Professor Coffman’s research interests include hypertension and diabetic nephropathy. Currently, he is the overall PI for DYNAMO, a Large Collaborative Grant (LCG) funded by the Singapore NMRC focused on understanding the pathogenesis of diabetic kidney disease.

Professor Coffman was conferred the 2014 Excellence Award for Hypertension Research from the AHA Council, the 2014 Distinguished Faculty Award from the Duke Medical Alumni Association and the 2022 Alumni Achievement Award from The Ohio State University College of Medicine.

Professor Coffman has previously served on the Boards of Directors for Singapore Health Services (SingHealth) and the Singapore Eye Research Institute (SERI), and was a member of the Singapore National Medical Research Council (NMRC). He currently serves on the Board of Directors for the King Faisal Specialist Hospital and Research Centre and is the Chairman of the Medical Advisory Committee and member of the Research Steering Committee for the National Kidney Foundation (NKF) of Singapore. He is also serving as an Advisor for the A*STAR Biomedical Research Council and one30 Therapeutics, a Singapore-based biotechnology company.