“Mechanisms of Immune Modulation by Dengue Virus”

Dengue viruses (DENV) can efficiently inhibit the generation of innate immune responses in infected cells. We found that the DENV protease complex mediates the evasion of innate immunity by targeting and inducing the degradation of factors such as cGAS and STING. Leakage of mitochondrial DNA induced during DENV infection can trigger the activation of the cGAS/STING pathway of type I IFN production. Additionally, different DENV serotypes can induce different immune profiles in infected cells, thus we analyzed those responses by CYTOF to understand the pathogenesis and kinetics of those viruses.

Fernandez-Sesma is a Professor of Microbiology at Icahn School of Medicine at Mount Sinai. Her group studies the modulation of innate immunity by viruses, such as dengue (DENV), influenza (IAV), and others using primary human systems.

She participates in several multi-investigator projects that use OMICS technologies to study viral infections. She has co-authored over 70 publications and is on the editorial board of several journals and serves in NIH study sections. She is also very committed to mentoring.

Professor Ooi Eng Eong
Programme in Emerging Infectious Diseases

Shirley William
shirleywilliam@duke-nus.edu.sg

Meeting Room 7C (Level 7)
Duke-NUS Medical School
8 College Road, Singapore 169857