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Associate Professor Track V, Psychiatry and Behavioral Sciences, Duke University Medical Center
Our laboratory works in the areas of genome-scale biology and bioinformatics. We apply advanced computational and quantitative analysis to genome-scale data, especially next-generation sequencing data in pursuit of questions in cancer biology. Areas of particular interest are cancer classification, detection of signatures of mutagenic exposures in tumors, and the roles of alternative splicing in cancer.
In bioinformatics, we develop approaches for analyzing and interpreting high-dimensional, genome-scale data sets, such as those generated by next-generation sequencing and by gene-expression arrays.
Technologies for generating genome-scale data are improving exponentially and are increasingly central in biological research. In bioinformatics, our goal is to develop robust tools that can use these genome-scale data to generate new insights into biological processes.
Steve Rozen also directs the Duke-NUS Centre for Computational Biology.
J. Tan, C.K. Ong, W.K. Lim, C.C.Y. Ng, A.A. Thike, L.M. Ng, V. Rajasegaran, S.S. Myint, S. Nagarajan, S. Thangaraju, S. Dey, N.D. Md Nasir, G.C. Wijaya, J.Q. Lim, D. Huang, Z. Li, B.H. Wong, J.Y.S. Chan, J.R McPherson, I. Cutcutache, G. Poore, S.T. Tay, W.J. T. Tan, C. Putti, B.S. Ahmad, P. Iau, C.W. Chan, A.P.T. Tang, W.S. Yong, P. Madhukumar, G.H. Ho, V.K.M. Tan, C.Y. Wong, M. Hartman, K.W. Ong, B.K.T. Tan, S.G Rozen*, P. Tan*, P.H. Tan*, B.T. Teh*. "Genomic landscapes of breast fibroepithelial tumors" Nat. Genet. (2015) (* = corresponding author) Advanced online publication. IF 29.35
I. Cutcutache, A.Y. Wu, Y. Suzuki, J.R. McPherson, Z. Lei, N. Deng, S. Zhang, W.K. Wong, K.C. Soo, W.H. Chan, L.L. Ooi, R. Welsch, P. Tan, S.G. Rozen. "Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma" Gastric Cancer 1-13 (2015) IF 3.71
I. Cutcutache, Y. Suzuki, I. B. Tan, S. Ramgopal, S. Zhang, K. Ramnarayana, A. Gan, H.H. Lee, S.T. Tay, A. Ooi, C.K. Ong, J.T. Bolthouse, B.R. Lane, J.G. Anema, R.J. Kahnoski, P. Tan*, B.T. Teh*, S.G. Rozen*. "Exome-wide sequencing shows low mutation rates and identifies novel mutated genes in seminomas" Eur. Urol. 68(1):77-83 (2015) (* = corresponding author). Designated "Platinum Priority" and highlighted in a journal editorial. IF 13.93
S.L. Poon, M.N. Huang, Y. Choo, J.R. McPherson, W. Yu, H.L. Heng, A. Gan, S.S. Myint, E.Y. Siew, L.D. Ler, L.G. Ng, W.-H. Weng, C.-K. Chuang, J.S.P Yuen, S.-T. Pang*, P. Tan*, B.T. Teh*, S.G. Rozen*. "Mutation signatures implicate aristolochic acid in bladder cancer development" Genome Med. 7:38 (2015) (* = corresponding author) IF 4.94
I. Tan, S. Malik, K. Ramnarayanan, J. McPherson, D. Ho, Y. Suzuki, S. Ng, S. Yan, K. Lim, D. Koh, C. Hoe, C. Chan, R. Ten, B. Goh, A. Chung, J. Tan, C. Chan, S. Tay, L. Alexander, N. Nagarajan, A. Hillmer, C. Tang, C. Chua, B. Teh, S. Rozen, P. Tan. "High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer" Genome Biol. 16:32 (2015) IF 10.47
W.K. Lim, C.K. Ong, J. Tan, A.A. Thike, C.C. Ng, V. Rajasegaran, S.S. Myint, S. Nagarajan, N.D. Nasir, J.R. McPherson, I. Cutcutache, G. Poore, S.T. Tay, W.S. Ooi, V.K. Tan, M. Hartman, K.W. Ong, B.K. Tan, S.G. Rozen*, P.H. Tan*, P. Tan*, B.T. Teh*. "Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma” Nat. Genet. 46:877-880 (2014) (* = corresponding author) IF 29.6
S.L. Poon, J.R. McPherson, P. Tan, B.T. Teh, S.G. Rozen. "Genome wide carcinogen signatures promise new opportunities for cancer prevention" Genome Med. (review) 6:24 (2014) IF 4.9
Z. Lei, I.B. Tan, K. Das, N. Deng, H. Zouridis, S. Pattison, C. Chua, Z. Feng, Y.K. Guan, C.H. Ooi, T. Ivanova, S. Zhang, M. Lee, J. Wu, A. Ngo, S. Manesh, E. Tan, B.T. Teh, J.B. Yan So, L.K. Goh, A. Boussioutas, T.K. Hon Lim, H. Flotow, P. Tan, S.G. Rozen. "Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase Inhibitors and 5-fluorouracil” Gastroenterology 145:554-565 (2013) (received journal editorial) IF 13.9
S.L. Poon, S.-T. Pang*, J.R. McPherson, W. Yu, K.K. Huang, P. Guan, W.-H. Weng, E.Y. Siew, Y. Liu, H..L. Heng, S.C. Chong, A. Gan, S.T. Tay, W.K. Lim, I. Cutcutache, D. Huang, L.D. Ler, M.-L. Nairismägi, M.H. Lee, Y.-H. Chang, K.-J. Yu, W. Chan-on, B.-K. Li, Y.-F. Yuan, C.-N. Qian, K.-F. Ng, C.-F. Wu, C.-L. Hsu, R. M. Bunte, M.R. Stratton, P.A. Futreal, W.-K. Sung, C.-K. Chuang, C.K. Ong, S.G. Rozen*, P. Tan*, B.T. Teh* "Genome wide mutational signatures of aristolochic acid and its application as a screening tool. " Sci. Transl. Med. 5:197ra101 (2013) (Received journal cover image and focus article; also highlighted by Science Magazine and The Scientist; (* = corresponding author) IF 14.4
A. Untergasser, I. Cutcutache, T. Koressaar, J. Ye, B.C. Faircloth, M. Remm, S.G. Rozen. "Primer3 - New capabilities and interfaces” Nucleic Acids Res. 40:e115 (2012) IF 8.3
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