Smith, Gavin JD

PhD

Professor

Emerging Infectious Diseases Programme

Other Affiliations:

Associate Research Professor, Duke Global Health Institute, Duke University, Durham, NC, United States
Faculty Member, Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
Visiting Scientist, WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Melbourne, Australia
Member, NIAID/NIH Center of Excellence for Influenza Research and Surveillance, St Jude Children’s Research Hospital, Memphis, TN, USA

+65 6601 1109

+65 6221 2529

Email 1:

gavin.smith@duke-nus.edu.sg

Research Bio Container

Research

Research Interest:

My research is highly collaborative and involves working with clinicians, veterinarians, epidemiologists, ecologists, ornithologists, mathematicians and computer scientists to integrate diverse experimental approaches. The unifying theme of my work is to understand the underlying processes of disease emergence. We conduct research that integrates ideas from a number of different fields including evolutionary genetics, virology, ecology, and infectious disease epidemiology. My team conducts human and animal disease surveillance; isolate and characterize (genetic and phenotypic) the pathogen; and then conduct large-scale analyses to generate hypotheses that are tested using tissue culture and animal models. I am primarily interested in the roles played by mutation, natural selection, recombination/reassortment and host immune response on virus diversity within an individual, during transmission within a population and during inter-species transmission between hosts. I work mostly on influenza but also study a wide range of respiratory viruses and emerging infectious diseases.

I have published over 90 peer-reviewed articles that are cited collectively more than 700 times per year, leading to an H index of 48 and >14,000 lifetime citations. My contributions are internationally recognized and I have received numerous research awards including the Chris Baldock Prize for Early Career Researchers, Australia (2007); Outstanding Young Researcher, The University of Hong Kong, China (2009); DMID/NIAID/NIH USA Special Recognition Award “In honor of extraordinary work in H1N1 influenza research” (2010); NIAID/NIH USA Selected Science Advances 2009 awarded for Rapid characterization of the 2009 H1N1 influenza virus (2010); Research Output Prize 2009–10 and 2011–12, Li Ka Shing Faculty of Medicine, The University of Hong Kong (2010 and 2012); and he was appointed as Beijerinck Guest Chair, Beijerinck Virology Fund, Royal Netherlands Academy of Arts and Sciences, Kingdom of the Netherlands (2011).

Selected Publications:

Joseph U, Dhanasekaran V, Smith GJD, Su YCF (2017). Adaptive evolution during the establishment of European avian-like H1N1 influenza A virus in swine. Evolutionary Applications (In press).

Mendenhall IH, Borthwick S, Sena Neves E, Low D, Linster M, Dhanasekaran V, Liang B, Skiles M, Jayajumar J, Han H, Gunalan V, Lee BPY-H, Okahara K, Wang LF, Maurer-Stroh S, Su YCF, Smith GJD (2016). Identification of a lineage D Betacoronavirus in cave nectar bats (Eonycteris spelaea) in Singapore and an overview of lineage D reservoir ecology in SE Asian bats. Transboundary and Emerging Diseases doi:10.1111/tbed.12568.

Mendenhall IH, Low D, Sena Neves E, Anwar A, Oh S, Su YCF, Smith GJD (2016). Evidence of canine parvovirus transmission to a civet cat (Paradoxurus hermaphrodites) in Singapore. One Health 2: 122-125.

Bahl J, Pham TT, Hill NJ, Hussein ITM, Ma EJ, Easterday BC, Halpin RA, Stockwell TB, Wentworth DE, Kayali G, Krauss S, Schultz-Cherry S, Webster RG, Webby RJ, Swartz M, Smith GJD, Runstadler JA (2016). Ecosystem interactions underlie the spread of avian influenza A viruses with pandemic potential. PLoS Pathogens 12: e1006203.

Su YCF, Bahl J, Joseph U, Butt KM, Koay ESC, Oon LLE, Barr IG, Vijaykrishna D, Smith GJD (2015). Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune driven selection. Nature Communications 6:7952.

Vijaykrishna D, Holmes EC, Joseph U, Fourment M, Su YCF, Halpin R, Lee RTC, Deng Y-M, Gunalan V, Lin X, Stockwell T, Fedorova NB, Zhou B, Spirason N, Kühnert D, Boškováh V, Stadler T, Costai A, Dwyer DE, Huang QS, Jennings LC, Rawlinson W, Sullivan SG, Hurt A, Maurer-Stroh S, Wentworth D, Smith GJD, Barr IG (2015). The contrasting pyhlodynamics of human influenza B virus. eLife 2015;10.7554/eLife.05055.

Bahl J, Krauss S, Kühnert D, Fourment M, Raven G, Pryor SP, Niles LJ, Danner A, Walker D, Mendenhall I, Su YCF, Dugan VG, Halpin RA, Stockwell TB, Webby RJ, Wentworth DE, Drummond AJ, Smith GJD, Webster RG (2013). Influenza A virus migration and persistence in North American wild birds. PLoS Pathogens 9: e1003570.

Bahl, J., Nelson, M.I., Chan, K.H., Chen, R., Vijaykrishna, D., Halpin, R.A., Stockwell, T.B., Lin, X., Wentworth, D.E., Ghedin, E., Guan, Y., Peiris, J.S.M., Riley, S., Rambaut, A., Holmes, E.C., and Smith, G.J.D. (2011). Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. Proc. Natl. Acad. Sci. USA 108(48):19359–19364.

Vijaykrishna, D., Smith, G.J.D., Pybus, O.G., Zhu, H., Bhat, S., Poon, L.L.M., Riley, S., Bahl, J., Ma, S.K., Cheung, C.L., Perera, R.A.P.M., Chen, H., Shortridge K.F., Webby, R.J., Webster, R.G., Guan, Y., and Peiris, J.S.M. (2011). Long-term evolution and transmission dynamics of swine influenza A virus. Nature 473, 519–522.

Smith, G.J.D., Vijaykrishna, D., Bahl, J., Lycett, S.J., Worobey, M., Pybus, O.G., Ma, S.K., Cheung, C.L., Raghwani, J., Bhatt, S., Peiris, J.S.M., Guan, Y., and Rambaut, A. (2009). Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459: 1122–1125.

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Smith, Gavin JD

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